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Adherence to Gender Affirming Hormone Therapy in Transgender Adolescents and Adults: A Retrospective Cohort Study
CONCLUSION: GAHT discontinuation is uncommon when therapy follows Endocrine Society guidelines. Future research should include prospective studies with long-term follow up of individuals receiving GAHT.PMID:37246711 | DOI:10.1210/clinem/dgad306
Source: The Journal of Clinical Endocrinology and Metabolism - May 29, 2023 Category: Endocrinology Authors: Pranav Gupta Briana C Patterson Lena Chu Sarah Gold Seth Amos Howa Yeung Michael Goodman Vin Tangpricha Source Type: research

Effects of sleep fragmentation and estradiol decline on cortisol in a human experimental model of menopause
CONCLUSIONS: Both estradiol suppression and modifiable menopause-related sleep fragmentation independently perturb HPA axis activity. Sleep fragmentation, commonly seen in menopausal women, may disrupt the HPA axis, which in turn may lead to adverse health effects as women age.PMID:37207451 | DOI:10.1210/clinem/dgad285
Source: The Journal of Clinical Endocrinology and Metabolism - May 19, 2023 Category: Endocrinology Authors: Aviva Y Cohn Leilah K Grant Margo D Nathan Aleta Wiley Mathena Abramson Jessica A Harder Sybil Crawford Elizabeth B Klerman Frank A J L Scheer Ursula B Kaiser Shadab A Rahman Hadine Joffe Source Type: research

Disruption of sleep continuity during the perimenopause: Associations with female reproductive hormone profiles
CONCLUSION: Associations of more awakenings with lower estradiol and higher FSH levels provide support for a perimenopause-associated sleep discontinuity condition that is linked with female reproductive hormone changes, independent of nVMS and DepSx.PMID:35878624 | DOI:10.1210/clinem/dgac447
Source: The Journal of Clinical Endocrinology and Metabolism - July 25, 2022 Category: Endocrinology Authors: Jamie Coborn Anouk de Wit Sybil Crawford Margo Nathan Shadab Rahman Lauren Finkelstein Aleta Wiley Hadine Joffe Source Type: research

Sleep fragmentation and estradiol suppression decrease fat oxidation in pre-menopausal women
CONCLUSIONS: Sleep fragmentation and hypoestrogenism each independently alter fasting substrate oxidation in a manner that may contribute to body fat gain. These findings are important for understanding mechanisms underlying propensity to body fat gain in women across the menopause transition.PMID:35569055 | DOI:10.1210/clinem/dgac313
Source: The Journal of Clinical Endocrinology and Metabolism - May 15, 2022 Category: Endocrinology Authors: Leilah K Grant Jamie E Coborn Aviva Cohn Margo D Nathan Frank A J L Scheer Elizabeth B Klerman Ursula B Kaiser Jessica Harder Mathena Abramson Elkhansaa Elguenaoui Julia A Russell Aleta Wiley Shadab A Rahman Hadine Joffe Source Type: research

Association between serum estradiol levels prior to progesterone administration in artificial frozen-thawed blastocyst transfer cycles and live birth rate: a retrospective study
CONCLUSION: High serum E2 levels prior to progesterone administration in AEP are associated with decreased LBR after frozen-thawed blastocyst transfer.PMID:34047447 | DOI:10.1111/1471-0528.16777
Source: BJOG : An International Journal of Obstetrics and Gynaecology - May 28, 2021 Category: OBGYN Authors: Ruiqiong Zhou Xiqian Zhang Li Huang Xiulan Zhu Mei Dong Wenjuan Liu Songlu Wang Fenghua Liu Source Type: research

Compromised Volumetric Bone Density and Microarchitecture in men with Congenital Hypogonadotropic Hypogonadism
CONCLUSION: Both vBMD and bone microarchitecture remain impaired in CHH/KS men despite long-term hormonal treatment. Treatment initiation during adolescence is associated with enhanced trabecular outcomes, highlighting the importance of early diagnosis.PMID:33725720 | DOI:10.1210/clinem/dgab169
Source: The Journal of Clinical Endocrinology and Metabolism - March 16, 2021 Category: Endocrinology Authors: Agn ès Ostertag Georgios E Papadakis Corinne Collet Severine Trabado Luigi Maione Nelly Pitteloud Jerome Bouligand Marie Christine De Vernejoul Martine Cohen-Solal Jacques Young Source Type: research

The comparison of the effectiveness and safety of drospirone ethinyl estradiol and ethinyl estradiol cyproterone in the treatment of polycystic ovarian syndrome: A protocol for systematic review and meta-analysis
Conclusion: The results of this study will provide theoretical basis for the drug treatment of polycystic ovarian syndrome and provide help in the decision-making of clinical treatment of the disease. Ethics and dissemination: In this study, meta-analysis was used to conduct a second study on the published literature. Therefore, this type of systematic review research does not need to be approved by ethics. OSF Registration DOI: 10.17605/OSF.IO/8GW9M.
Source: Medicine - December 18, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Fight Aging! Newsletter, July 20th 2020
This study was the first to demonstrate a causal relationship between glial senescence and neurodegeneration. In this study, accumulations of senescent astrocytes and microglia were found in tau-associated neurodegenerative disease model mice. Elimination of these senescent cells via a genetic approach can reduce tau deposition and prevent the degeneration of cortical and hippocampal neurons. Most recently, it was shown that clearance of senescent oligodendrocyte progenitor cells in AD model mice with senolytic agents could lessen the Aβ plaque load, reduce neuroinflammation, and ameliorate cognitive deficits. This...
Source: Fight Aging! - July 19, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, July 22nd 2019
This study elucidates the potential to use mitochondria from different donors (PAMM) to treat UVR stress and possibly other types of damage or metabolic malfunctions in cells, resulting in not only in-vitro but also ex-vivo applications. Gene Therapy in Mice Alters the Balance of Macrophage Phenotypes to Slow Atherosclerosis Progression https://www.fightaging.org/archives/2019/07/gene-therapy-in-mice-alters-the-balance-of-macrophage-phenotypes-to-slow-atherosclerosis-progression/ Atherosclerosis causes a sizable fraction of all deaths in our species. It is the generation of fatty deposits in blood vessel...
Source: Fight Aging! - July 21, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

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