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Total 9822 results found since Jan 2013.

Primary Occurrence of Cardiovascular Events After Adding Sodium-Glucose Cotransporter-2 Inhibitors or Glucagon-like Peptide-1 Receptor Agonists Compared With Dipeptidyl Peptidase-4 Inhibitors: A Cohort Study in Veterans With Diabetes
CONCLUSION: The addition of GLP1RA was associated with primary reductions of MACE and HF hospitalization compared with DPP4i use; SGLT2i addition was not associated with primary MACE prevention.PRIMARY FUNDING SOURCE: VA Clinical Science Research and Development and supported in part by the Centers for Diabetes Translation Research.PMID:37155984 | DOI:10.7326/M22-2751
Source: Annals of Internal Medicine - May 8, 2023 Category: Internal Medicine Authors: Tadarro L Richardson Alese E Halvorson Amber J Hackstadt Adriana M Hung Robert Greevy Carlos G Grijalva Tom A Elasy Christianne L Roumie Source Type: research

A nurse ‐led intervention in patients with newly diagnosed cancer and Type 2 diabetes: A pilot randomized controlled trial feasibility study
ConclusionThis study was not feasible due to recruitment inefficiencies, but acceptable to all who qualified.
Source: Cancer Medicine - May 22, 2023 Category: Cancer & Oncology Authors: Lisa Scarton, Tarah Nelson, Ara Jo, LaToya J. O ’Neal, Yingwei Yao, Shavondra Huggins, Anatolia B. Legaspi, Mariah J. McClaren, Jake S. Cabassa, Joan M. Burgos Melendez, Juan M. Munoz‐Pena, Merry J. Markham, Martina C. Murphy, Jonathan A Tags: BRIEF COMMUNICATION Source Type: research

Added benefit of saxagliptin/metformin combination is not proven
(Institute for Quality and Efficiency in Health Care) The fixed combination of saxagliptin and metformin has no added benefit compared to the current standard treatment for people with type 2 diabetes, as the drug manufacturer did not submit any suitable data for this comparison. This is the conclusion of a dossier assessment by the German Institute for Quality and Efficiency in Health Care, Cologne, which was published in February 2013 and for which an English-language extract is now available.
Source: EurekAlert! - Medicine and Health - April 29, 2013 Category: Global & Universal Source Type: news

L-Carnitine for the Treatment of a Calcium Channel Blocker and Metformin Poisoning.
DISCUSSION: L-Carnitine combined with HDI may have helped with the calcium channel blocker (CCB) poisoning by decreasing insulin resistance, promoting intracellular glucose transport, facilitating the metabolism of free fatty acids, and increasing calcium channel sensitivity. It may have also stimulated oxidative utilization of glucose instead of converting pyruvate into lactate and contributed to decrease lactate production with metformin poisoning. PMID: 23636657 [PubMed - as supplied by publisher]
Source: Journal of Medical Toxicology - May 2, 2013 Category: Toxicology Authors: St-Onge M, Ajmo I, Poirier D, Laliberté M Tags: J Med Toxicol Source Type: research

Metformin use and the prognostic value of lactate in sepsis
Source: Notes from Dr. RW - June 5, 2013 Category: Internists and Doctors of Medicine Tags: critical care endocrinology Source Type: blogs

37 yo with 1.5 hours of burning chest pain
A 37 year old with a history of DM on metformin complained of acute onset of burning chest pain.  He called 911. They did an ECG but it is not available.  However, the medics were very concerned and brought him to the critical care area with a high suspicion of STEMI.  Here is the initial ECG: This shows sinus rhythm and abnormal septal Q-waves in V1 and V2, with what appear to be hyperacute T-waves in V2-V4.  The computer read ***Acute MI***.  Though the early repol vs. anterior STEMI formula, strictly speaking, should not be used because there are Q-waves, if you did, you would use S...
Source: Dr. Smith's ECG Blog - June 16, 2013 Category: Cardiology Authors: Steve Smith Source Type: blogs

Top stories in health and medicine, June 24, 2013
Brought to you by MedPage Today. 1. Risk Model May Catch Type 1 Diabetes Early. A threshold based on risk prediction data from a large epidemiological study of type 1 diabetes may help better predict which patients will develop the disease. 2. Drug Combo Beats Step-Up Tx in New T2D. Starting newly-diagnosed type 2 diabetes patients on triple combination therapy rather than progressing step-wise up from metformin keeps glucose lower for longer. 3. Needs Likely to Be Great When Uninsured Get Medicaid. Many currently uninsured adults will soon be eligible for Medicaid under the Affordable Care Act, and while these individual...
Source: Kevin, M.D. - Medical Weblog - June 24, 2013 Category: Family Physicians Tags: News Diabetes Endocrinology Source Type: blogs

Top stories in health and medicine, August 28, 2013
From MedPage Today: ACOs Can Save Medicare $$$, Study Finds. An accountable care organization (ACO) established by a private insurer reduced costs of care for Medicare enrollees. More Exercise, Metformin Alter Lipid Particles. Both metformin and changes in diet and exercise made significant changes to the size and types of lipid particles in patients with impaired glucose tolerance. Ultrasound May Cut Thyroid Biopsy Rate. Certain characteristics of thyroid nodules identified on ultrasound can help predict the likelihood of cancer, and may also help determine if fine-needle aspiration biopsy can be deferred. Under-the-Ski...
Source: Kevin, M.D. - Medical Weblog - August 28, 2013 Category: Family Physicians Tags: News Endocrinology Heart Medicare Medications Source Type: blogs

The use of oral hypoglycaemic agents in pregnancy
This article is protected by copyright. All rights reserved.
Source: Diabetic Medicine - December 1, 2013 Category: Endocrinology Authors: R. I. G. Holt, K. Lambert Tags: Review Source Type: research

Do geriatrics require dose titration for antidiabetic agents?
Conclusion: A substantial dose reduction of glibenclamide (25%), gliclazide (25%), glimepiride (22%), and metformin (5%) in geriatrics compared to nongeriatrics was observed. Smaller dosage formulations like 0.75 mg glibenclamide, 0.5 mg glimepiride, 20 mg gliclazide, and 250 mg metformin may be of value in geriatric diabetic practice.
Source: Journal of Postgraduate Medicine - December 17, 2013 Category: Internal Medicine Authors: R ShastryP AdhikariA KamathM ChowtaS UllalMRSM Pai Source Type: research

Persistent Oral Manifestations in Woman With Pemphigus Vulgaris: Case Report
This report shows the possible occurrence of resistant oral lesions in PV and the need for dentists to have extensive knowledge about this entity to provide correct management.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - January 21, 2014 Category: ENT & OMF Authors: ANA LÚCIA DA SILVA MOREIRA, ANA LUÍZA FERREIRA DA SILVA, EMELINE DAS NEVES DE ARAÚJO LIMA, MARCELO GADELHA VASCONCELOS, ANTÔNIO DE LISBOA LOPES COSTA, ANA MIRYAM COSTA DE MEDEIROS, ÉRICKA JANINE DANTAS DA SILVEIRA Tags: Online Only Articles Source Type: research

Weight Gain and Glucose Dysregulation with Second-Generation Antipsychotics and Antidepressants:
A Review for Primary Care Physicians Mehrul Hasnain, MD; W. Victor R. Vieweg, MD; Bruce Hollett, MD DOI: 10.3810/pgm.2012.07.2577 Abstract: Second-generation antipsychotics (SGAPs) and second-generation antidepressants (SGADs) have multiple US Food and Drug Administration–approved indications and are frequently prescribed by primary care physicians. We review the relative potential of these drugs to cause weight gain and glucose dysregulation, and offer clinical guidance to minimize and manage this risk. Among SGAPs, clozapine and olanzapine have a high risk for causing weight gain and glucose dysregulatio...
Source: Postgraduate Medicine Online - August 8, 2012 Category: Internal Medicine Authors: admin Source Type: research

Drug utilization study in diabetic patients attending medicine outpatient department of a tertiary care hospital
Abstract A cross-sectional observational study of 6 months duration was done in a tertiary care hospital to determine the drug utilization pattern among diabetic outpatients. We analyzed the collected data by using descriptive statistics and determined drug use indicators, defined daily dose (DDD)/1000 inhabitants/day and utilization pattern of antidiabetic drug. Antidiabetic drugs were classified according to Anatomical Therapeutic Chemical (ATC) classification and their consumption was measured in terms of DDD/1000 inhabitants/day. 625 prescriptions were collected during this study. Type 2 diabetes mellitus (T2...
Source: International Journal of Diabetes in Developing Countries - October 24, 2014 Category: Endocrinology Source Type: research