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Mortality-related risk factors of inpatients with diabetes and COVID-19: a multicenter retrospective study in Belgium
CONCLUSION: In-hospital mortality due to the first wave of the COVID-19 pandemic in Belgium was high in patients with diabetes. We found that advanced age and male gender were independent risk factors for in-hospital death. We also showed that metformin use before admission was associated with significantly lower COVID-19-related in-hospital mortality. Finally, we showed that CKD is a COVID-19-related mortality risk factor in patients with diabetes admitted to the ICU.PMID:37574109 | DOI:10.1016/j.ando.2023.08.002
Source: Annales d'Endocrinologie - August 13, 2023 Category: Endocrinology Authors: Thomas Servais France Laurent Thomas Roland Camelia Rossi Elodie De Groote Val érie Godart Ernestina Repetto Michel Ponchon Pascale Chasseur Laurent Crenier Sandrine Van Eeckhoudt John Yango Philippe Oriot Mirela Morisca Gavriliu St éphanie Rouhard Benj Source Type: research
Injectable periodontal ligament stem cell-metformin-calcium phosphate scaffold for bone regeneration and vascularization in rats
CONCLUSIONS: The novel injectable construct with hPDLSC and Met encapsulation demonstrated excellent efficacy for bone regeneration and vascularization in vivo in an animal model. CPC+hPDLSCs+ 0.1%Met is highly promising for dental and craniofacial applications.PMID:37574338 | DOI:10.1016/j.dental.2023.07.008
Source: Cancer Control - August 13, 2023 Category: Cancer & Oncology Authors: Yaxi Sun Zeqing Zhao Qingchen Qiao Shengnan Li Wenting Yu Xiuchen Guan Abraham Schneider Michael D Weir Hockin H K Xu Ke Zhang Yuxing Bai Source Type: research
Mortality-related risk factors of inpatients with diabetes and COVID-19: a multicenter retrospective study in Belgium
CONCLUSION: In-hospital mortality due to the first wave of the COVID-19 pandemic in Belgium was high in patients with diabetes. We found that advanced age and male gender were independent risk factors for in-hospital death. We also showed that metformin use before admission was associated with significantly lower COVID-19-related in-hospital mortality. Finally, we showed that CKD is a COVID-19-related mortality risk factor in patients with diabetes admitted to the ICU.PMID:37574109 | DOI:10.1016/j.ando.2023.08.002
Source: Annales d'Endocrinologie - August 13, 2023 Category: Endocrinology Authors: Thomas Servais France Laurent Thomas Roland Camelia Rossi Elodie De Groote Val érie Godart Ernestina Repetto Michel Ponchon Pascale Chasseur Laurent Crenier Sandrine Van Eeckhoudt John Yango Philippe Oriot Mirela Morisca Gavriliu St éphanie Rouhard Benj Source Type: research
Metformin Improves Comorbid Depressive Symptoms in Mice with Allergic Rhinitis by Reducing Olfactory Bulb Damage
In conclusion, our findings suggest that metformin might be a viable strategy for treating AR-related depression, possibly by modulating neuroplasticity, neurogenesis, apoptosis, and BDNF signaling in the OB via the AMPK/TET2 pathway.PMID:37574530 | DOI:10.1007/s11064-023-04012-9
Source: Neurochemical Research - August 13, 2023 Category: Neuroscience Authors: Hao Lv Ziang Gao Yunfei Wang Siyuan Chen Peiqiang Liu Yulie Xie Mengting Guan Jianchao Cong Yu Xu Source Type: research
Extensive therapeutic effects, underlying molecular mechanisms and disease treatment prediction of Metformin: a systematic review
Transl Res. 2023 Aug 9:S1931-5244(23)00130-5. doi: 10.1016/j.trsl.2023.08.001. Online ahead of print.ABSTRACTMetformin, a first-line management for Type 2 Diabetes Mellitus, has been expansively employed and studied with results indicating its therapeutic potential extending beyond glycaemic control. Beyond its established role, this therapeutic drug demonstrates a broad spectrum of action encompassing over sixty disorders, encompassing metabolic conditions, inflammatory disorders, carcinomas, cardiovascular diseases, and cerebrovascular pathologies. There is clear evidence of metformin's action targeting specific nodes in...
Source: Translational Research : the journal of laboratory and clinical medicine - August 11, 2023 Category: Laboratory Medicine Authors: Yifei Geng Zhen Wang Xiaoyu Xu Xiao Sun Xi Dong Yun Luo Xiaobo Sun Source Type: research
Polycystic ovary syndrome and thyroid disorder: a comprehensive narrative review of the literature
ConclusionPCOS and thyroid disorders are closely related, and their coexistence may identify patients with a higher reproductive and metabolic risk. Regular screening for thyroid function and thyroid-specific autoantibodies in women with PCOS, particularly before and during pregnancy, is highly recommended.
Source: Frontiers in Endocrinology - August 11, 2023 Category: Endocrinology Source Type: research
Novel pharmacological approaches in abdominal aortic aneurysm
Clin Sci (Lond). 2023 Aug 14;137(15):1167-1194. doi: 10.1042/CS20220795.ABSTRACTAbdominal aortic aneurysm (AAA) is a severe vascular disease and a major public health issue with an unmet medical need for therapy. This disease is featured by a progressive dilation of the abdominal aorta, boosted by atherosclerosis, ageing, and smoking as major risk factors. Aneurysm growth increases the risk of aortic rupture, a life-threatening emergency with high mortality rates. Despite the increasing progress in our knowledge about the etiopathology of AAA, an effective pharmacological treatment against this disorder remains elusive and...
Source: Atherosclerosis - August 10, 2023 Category: Cardiology Authors: L ídia Puertas-Umbert Rafael Almendra-Pegueros Francesc Jim énez-Altayó Marc Sirvent Mar ía Galán Jos é Martínez-González Cristina Rodr íguez Source Type: research
Elevated glucose metabolism driving pro-inflammatory response in B cells contributes to the progression of type 1 diabetes
Clin Immunol. 2023 Aug 8:109729. doi: 10.1016/j.clim.2023.109729. Online ahead of print.ABSTRACTType 1 diabetes (T1D) is an autoimmune disease characterized by the immune system's failure to maintain self-tolerance, resulting in the autoimmune destruction of pancreatic beta cells. Although T1D has conventionally been viewed as a T-cell-dominant disease, recent research has emphasized the contribution of B cells in the onset of the disease. However, the mechanism underlying aberrant B cell responses remains unknown. B cell metabolism is a crucial prerequisite for B cell function and the development of adaptive immune respon...
Source: Clinical Immunology - August 10, 2023 Category: Allergy & Immunology Authors: Zeying Li Mingjiu Zhao Jingyue Li Wenjun Luo Juan Huang Gan Huang Zhiguo Xie Yang Xiao Jiaqi Huang Xia Li Bin Zhao Zhiguang Zhou Source Type: research
