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Infectious Disease: Parasitic Diseases
Drug: Fortamet

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Total 41 results found since Jan 2013.

Stimulation of glucose uptake by glycosides from < em > Alectra parasitica < /em > subsp. < em > chitrakutensis < /em > (M.A. Rau) K.K. Khanna & amp; An. Kumar: An < em > in-vitro < /em > study of TNF- α induced insulin resistance in L6 myoblasts
Nat Prod Res. 2022 Aug 19:1-7. doi: 10.1080/14786419.2022.2112957. Online ahead of print.ABSTRACTAlectra parasitica subsp. chitrakutensis (M.A. Rau) K.K. Khanna & An. Kumar (Orobanchaceae) is a parasitic plant indigenous to India. Locally, the plant is known as 'Midaki and Nirgundikand'. It is used to treat fever, piles, cardiovascular disorders, and blood-borne non-infectious diseases by ethnic communities. The phytochemical investigation of A. parasitica subsp. chitrakutensis rhizome led to the isolation of azafrin (1), rehmaionoside-C (2), and mussaenoside (3). Compounds (2) and (3) are being reported for the first ...
Source: Natural Product Research - August 19, 2022 Category: Biochemistry Authors: None Ranjana Monika Binwal Ashutosh Kumar Verma Dnyaneshwar U Bawankule Neerja Tiwari Karuna Shanker Source Type: research

An Overview of the Evidence and Mechanism of Drug –Herb Interactions Between Propolis and Pharmaceutical Drugs
With the growing interest in the medicinal use of propolis, numerous studies have reported significant interactions between propolis extract and pharmaceutical drugs which may result in great clinical benefits or risks. The present study aims to review the drug–herb interactions of the full-spectrum propolis extract and main pharmaceutical drugs from the pharmacodynamic and pharmacokinetic aspects and elucidate the underlying pharmacological mechanisms. A literature search was conducted between June 2021 and February 2022 in Google Scholar, PubMed, MEDLINE, and EMBASE databases to include English studies from years 2000 ...
Source: Frontiers in Pharmacology - April 4, 2022 Category: Drugs & Pharmacology Source Type: research

Proliferative cells in racemose neurocysticercosis have an active MAPK signalling pathway and respond to metformin treatment
Int J Parasitol. 2022 Feb 16:S0020-7519(22)00016-9. doi: 10.1016/j.ijpara.2022.01.001. Online ahead of print.ABSTRACTRacemose neurocysticercosis is an aggressive infection caused by the aberrant expansion of the cyst form of Taenia solium within the subarachnoid spaces of the human brain and spinal cord, resulting in the displacement of the surrounding host tissue and chronic inflammation. We previously demonstrated that the continued growth of the racemose bladder wall is associated with the presence of mitotically active cells but the nature and control of these proliferative cells are not well understood. Here, we demon...
Source: International Journal for Parasitology - February 19, 2022 Category: Parasitology Authors: Miguel A Orrego Manuela R Verastegui Carlos M Vasquez Hector H Garcia Theodore E Nash Cysticercosis Working Group in Peru Source Type: research

Fight Aging! Newsletter, February 14th 2022
In conclusion, this first examination of the effects of age and the ageing process on the small intestinal microbiome demonstrates that the duodenal microbiome changes with increasing age, with significant decreases in duodenal microbial diversity due to increased prevalence of phylum Proteobacteria, particularly coliforms and anaerobic taxa. Given the key roles of small intestinal microbes in nutrient absorption and host metabolism, these changes may be clinically relevant for human health during the ageing process. Naked Mole Rats Exhibit Minimal Cardiac Aging https://www.fightaging.org/archives/2022/02/naked...
Source: Fight Aging! - February 13, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

An adjuvant effect of Metformin as an anti-fibrotic agent when administered with the anti-schistosomal Praziquantel in Schistosoma mansoni infected mice
This study aimed to evaluate the role of Met as anti-schistosomal and anti-fibrotic agents alone or in combination with PZQ treatment. Forty male CD1 mice were divided into four groups (n=10 mice) as following; the first group (Gp1) was served as a negative control. Gp2, Gp3, Gp4, and Gp5 were infected with (60-80) S. mansoni cercariae. After a month of infection, Gp3 was administered orally with PZQ (500 mg/Kg) for 2 consecutive days. Gp4 was administered orally with Met (150 mg/Kg) for 15 consecutive days, and Gp5 was orally administered with PZQ followed by Met for 15 consecutive days at the same doses as in Gp 3 and 4....
Source: Tropical Biomedicine - June 26, 2021 Category: Tropical Medicine Authors: W M Salama S A El-Naggar S F Harras K S El-Said Source Type: research