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Specialty: Biochemistry
Drug: Temodar
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Total 45 results found since Jan 2013.
Co-loading of Temozolomide with Oleuropein or rutin into polylactic acid core-shell nanofiber webs inhibit glioblastoma cell by controlled release
In this study, we developed a nanofiber-based local therapy against GB cells using Oleuropein (OL), and rutin and their combinations with Temozolomide (TMZ). The polylactic acid (PLA) core-shell nanofiber webs were encapsulated with OL (PLAOL), rutin (PLArutin), and TMZ (PLATMZ) by an electrospinning process. A SEM visualized the morphology and the total immersion method determined the release characteristics of PLA webs. Real-time cell tracking analysis for cell growth, dual Acridine Orange/Propidium Iodide staining for cell viability, a scratch wound healing assay for migration capacity, and a sphere formation assay for ...
Source: International Journal of Biological Macromolecules - September 6, 2023 Category: Biochemistry Authors: Melis Ercelik Cagla Tekin Fatma Nur Par ın Busra Mutlu Hazal Y ılmaz Dogan Gulcin Tezcan Secil Ak Aksoy Melisa Gurbuz Kenan Y ıldırım Ahmet Bekar Hasan Kocaeli Mevlut Ozgur Taskapilioglu P ınar Eser Berrin Tunca Source Type: research
Comparative analysis of α-pinene alone and combined with temozolomide in human glioblastoma cells
Nat Prod Res. 2023 Sep 4:1-6. doi: 10.1080/14786419.2023.2252152. Online ahead of print.ABSTRACTα-Pinene (PEN) is a phyto compound present in terpene plants. In traditional medicine, PEN has been used for its anti-inflammatory, pain-relieving, and bronchodilator properties. The effect of PEN in combination with temozolomide (TMZ) in glioblastoma multiforme (GBM) cells has been evaluated. The action of the PEN + TMZ combination on cell migration, soft-agar, and cell death was determined in LN229 and U87MG human glioblastoma cells. In combination, PEN with TMZ showed a synergistic inhibitory effect in the GBM cells. The PEN...
Source: Natural Product Research - September 4, 2023 Category: Biochemistry Authors: Megha Gautam Reema Gabrani Source Type: research
Toward a theranostic device for gliomas
CONCLUSIONS: We present an improved formulation of PVA-MBs to achieve a multifunctional device with adhesion ability, cytotoxicity on glioblastoma cells and supporting imaging.PMID:37300942 | DOI:10.1016/j.bbrc.2023.05.089
Source: Biochemical and Biophysical Research communications - June 10, 2023 Category: Biochemistry Authors: Gaio Paradossi Rachel Grossman Francesco Riccitelli Federica Todaro Zvi Ram Sara Schioppa Fabio Domenici Source Type: research
Magnolol and Temozolomide exhibit a synergistic anti-glioma activity through MGMT inhibition
Biochim Biophys Acta Mol Basis Dis. 2023 Jun 5:166782. doi: 10.1016/j.bbadis.2023.166782. Online ahead of print.ABSTRACTTemozolomide (TMZ) is the leading chemotherapeutic agent used for glioma therapy due to its good oral absorption and blood-brain barrier permeability. However, its anti-glioma efficacy may be limited due to its adverse effects and resistance development. O6-Methylguanine-DNA-methyltransferase (MGMT), an enzyme associated with TMZ resistance, is activated via the NF-κB pathway, which is found to be upregulated in glioma. TMZ also upregulates NF-κB signaling like many other alkylating agents. Magnolol (MG...
Source: Biochimica et Biophysica Acta - June 7, 2023 Category: Biochemistry Authors: Moumita Kundu Subhayan Das Suvendu Nandi Dibakar Dhara Mahitosh Mandal Source Type: research
Lemur tyrosine kinase 2 has a tumor-inhibition function in human glioblastoma by regulating the RUNX3/Notch pathway
This study was carried out to determine the relevance of LMTK2 in GBM. Initiating investigation by assessing The Cancer Genome Atlas (TCGA) data showed LMTK2 mRNA levels were decreased in GBM tissue. Later examination of clinical specimens confirmed low levels of LMTK2 mRNA and protein in GBM tissue. The downregulated level of LMTK2 in patients with GBM was related to poor overall survival. A suppressive function of LMTK2 on the proliferative capability and metastatic potential of GBM cells was demonstrated by overexpressing LMTK2 in GBM cell lines. Moreover, the restoration of LMTK2 augmented the sensitivity of GBM cells ...
Source: Biochimica et Biophysica Acta - June 4, 2023 Category: Biochemistry Authors: Lei Zhang Peng Luo Xinggang Mao Jidong Sun Jialiang Wei Yuefan Yang Yanyu Zhang Xiaofan Jiang Source Type: research
The first evidence of biological activity for free Hypusine, an enigmatic amino acid discovered in the '70s
Amino Acids. 2023 May 31. doi: 10.1007/s00726-023-03283-4. Online ahead of print.ABSTRACTHypusine amino acid [Nε-(4-amino-2-hydroxybutyl)-lysine] was first isolated in 1971 from bovine brain extracts. Hypusine originates from a post-translational modification at the eukaryotic translation initiation factor 5A (eIF5A), a protein produced by archaebacteria and eukaryotes. The eIF5A protein is the only one described containing the hypusine residue, which is essential for its activity. Hypusine as a free amino acid is a consequence of proteolytic degradation of eIF5A. Herein, we showed, for the first time, evidence of biologi...
Source: Amino Acids - May 31, 2023 Category: Biochemistry Authors: Leticia Tamborlin Karina Danielle Pereira Dimitrius Santiago Passos Sim ões Fróes Guimarães Leonardo Reis Silveira Augusto Ducati Luchessi Source Type: research
