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Drug: Restasis
Therapy: Stem Cell Therapy

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Total 116 results found since Jan 2013.

Soluble CX3CL1-expressing retinal pigment epithelium cells protect rod photoreceptors in a mouse model of retinitis pigmentosa
CONCLUSIONS: Transgenic hESCs differentiate into hRPE cells and retain sCX3CL1 transgene expression both in vitro and in vivo. Moreover, hRPE cells delivered to the subretinal space of rd10 mice prevented photoreceptor degeneration in a local-acting manner, suggesting that this approach could have applications for preserving photoreceptors in specific subregions of the retina, such as the macula. Overall, our study not only reveals the potential of a combined cell and gene therapy for the treatment of RP, but also the possibility of using hRPE cells to deliver therapeutic biologics in situ to treat diseases over long-term....
Source: Cell Research - August 22, 2023 Category: Cytology Authors: Eric D Jong Sabiha Hacibekiroglu Lily Guo Evan Sawula Biao Li Chengjin Li Margaret T Ho Molly S Shoichet Valerie A Wallace Andras Nagy Source Type: research

Genes, Vol. 14, Pages 1655: PSTPIP1-Associated Myeloid-Related Proteinemia Inflammatory (PAMI) Syndrome: A Systematic Review
heodoropoulou PSTPIP1 (proline-serine-threonine phosphatase-interactive protein 1)-associated myeloid-related proteinemia inflammatory (PAMI) syndrome, previously known as Hyperzincemia/Hypercalprotectinemia (Hz/Hc) syndrome, is a recently described, rare auto-inflammatory disorder caused by specific deleterious variants in the PSTPIP1 gene (p.E250K and p.E257K). The disease is characterized by chronic systemic inflammation, cutaneous and osteoarticular manifestations, hepatosplenomegaly, anemia, and neutropenia. Increased blood levels of MRP 8/14 and zinc distinguish this condition from other PSTPIP1-associated inflam...
Source: Genes - August 19, 2023 Category: Genetics & Stem Cells Authors: Manel Mejbri Raffaele Renella Fabio Candotti Cecile Jaques Dirk Holzinger Michael Hofer Katerina Theodoropoulou Tags: Systematic Review Source Type: research

The reconstitution of T-cells after Allogeneic Hematopoietic Stem Cell Transplant in a Pediatric Patient with Congenital Amegakaryocytic Thrombocytopenia (CAMT)
CONCLUSION: Successful treatment of acute GvHD prevented advancing the condition to chronic GvHD, and this was accompanied by delayed T-cell reconstitution through an increase in Treg:Tcons ratio.PMID:37526450 | DOI:10.2174/1871530323666230801100113
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - August 1, 2023 Category: Endocrinology Authors: Shideh Namazi Bayegi Amir Ali Hamidieh Maryam Behfar Amene Saghazadeh Mahmood Bozorgmehr Nader Tajik Ali Akbar Delbandi Samaneh Delavari Mehdi Shekarabi Nima Rezaei Source Type: research

Occurrence and influencing factors of cyclosporine A on the kidney injury following allogeneic hematopoietic stem cell transplantation: A systematic review and meta-analysis
CONCLUSIONS: CsA may be a risk factor for kidney injury in patients following allo-HSCT, especially the concomitant use of CsA and nephrotoxic medications.PMID:37451015 | DOI:10.1016/j.intimp.2023.110633
Source: International Immunopharmacology - July 14, 2023 Category: Allergy & Immunology Authors: Runxin Lu Yuqing Shi Mengting Yang Nan Yang Siyi He Li Xin Yinpeng Qin Hailong Li Linan Zeng Kun Zou Chunsong Yang Liang Huang Wei Shi Xin Qiu Xiaoxi Lu Lingli Zhang Source Type: research

Cyclophosphamide with cyclosporine A for graft-versus-host disease prophylaxis in adult patients with acute myeloid leukemia undergoing allogeneic hematopoietic stem cell transplantation from human leucocyte antigen-matched donors
CONCLUSION: PT-CY followed by CSA was associated with low cumulative incidences of both aGVHD and cGVHD without increase in either the relapse or transplant-related complications; so, considered as a promising protocol to be widely applied in the settings of HLA-matched donors.PMID:37235962 | DOI:10.1016/j.intimp.2023.110374
Source: International Immunopharmacology - May 26, 2023 Category: Allergy & Immunology Authors: Mustafa O Sharaf El-Deen Moetaza M Soliman Gamal Al-Azab Mohamed Samra Mohammad E E Shams Source Type: research

Case report: Cyclosporine A-induced extrapyramidal syndrome following hematopoietic stem cell transplantation
ConclusionCyclosporine A can induce neurotoxicity resulting in diverse symptoms. Signs of EP are rare manifestations of cyclosporine neurotoxicity and should be considered when evaluating post-transplant recipients of cyclosporine when they are present with any EP symptoms. Discontinuation of cyclosporine results in good recovery in most patients.
Source: Frontiers in Neurology - April 17, 2023 Category: Neurology Source Type: research

Timing of cyclosporine administration for GvHD prophylaxis in haploidentical stem cell transplantation setting: Single center experience
Curr Res Transl Med. 2023 Mar 21;71(2):103387. doi: 10.1016/j.retram.2023.103387. Online ahead of print.NO ABSTRACTPMID:36966546 | DOI:10.1016/j.retram.2023.103387
Source: Cell Research - March 26, 2023 Category: Cytology Authors: Jean El Cheikh Layal Sharrouf Mahdi Hamade Khodr Terro Ghassan Bidaoui Maya Charafeddine Fatima Ismail Ammar Zahreddine Nour Moukalled Imane Abou Dalle Ali Bazarbachi Source Type: research

Successful Hematopoietic Stem Cell Transplant in a Patient with Omenn Syndrome: A Case Report
Exp Clin Transplant. 2023 Feb;21(2):189-193. doi: 10.6002/ect.2022.0348.ABSTRACTOmenn syndrome is a rare subtype of severe combined immunodeficiency. Affected patients present recurrent infections, lymphadenopathy, skin eruptions, eosinophilia, hepatosplenomegaly, failure to thrive, and gastrointestinal complications with variable severity. A 3-month-old female infant, born to consanguineous healthy parents, presented with splenomegaly, erythroderma, failure to thrive, and history of recurrent otitis media, hypothyroidism, and Bacille Calmette-Guérin lymphadenitis following Bacille Calmette-Guérin vaccination.The immunol...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - March 15, 2023 Category: Transplant Surgery Authors: Bibi Shahin Shamsian Amirreza Paksaz Zahra Chavoshzadeh Samin Sharafian Seyed Morteza Tabatabaee Yazdi Mahnaz Jamee Source Type: research