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Drug: Acetylcysteine
Therapy: Stem Cell Therapy
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Total 101 results found since Jan 2013.
Deciphering the mitophagy receptor network identifies a crucial role for OPTN (optineurin) in acute myeloid leukemia
Autophagy. 2023 Jul 13:1-15. doi: 10.1080/15548627.2023.2230839. Online ahead of print.ABSTRACTThe selective autophagic degradation of mitochondria via mitophagy is essential for preserving mitochondrial homeostasis and, thereby, disease maintenance and progression in acute myeloid leukemia (AML). Mitophagy is orchestrated by a variety of mitophagy receptors whose interplay is not well understood. Here, we established a pairwise multiplexed CRISPR screen targeting mitophagy receptors to elucidate redundancies and gain a deeper understanding of the functional interactome governing mitophagy in AML. We identified OPTN (optin...
Source: Autophagy - July 13, 2023 Category: Cytology Authors: Laura M Meyer Sebastian E Koschade Jonas B Vischedyk Marlyn Thoelken Andrea Gubas Martin Wegner Marion Basoglu Stefan Knapp Manuel Kaulich Stefan Eimer Shabnam Shaid Christian H Brandts Source Type: research
Fight Aging! Newsletter, December 26th 2022
This article on senolytic therapies to selectively remove senescent cells in old tissues is in part a matter of Unity Biotechnology talking up their position. The company suffered from first mover disadvantage in bringing senolytic drugs into clinical development. The field has made progress very rapidly over the last decade, and startups founded even just a couple of years after Unity's launch benefited from greater knowledge and a selection of better technologies to work with. Still, one can be talking up one's position and also be right. The accumulation of senescent cells is profoundly harmful, a significant contributi...
Source: Fight Aging! - December 25, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Mechanosensitive Stem-Cell Genes and Klotho in Atherosclerotic Aortas: Regulating Spatially Deranged Expression Patterns Using Colchicine Regimens
CONCLUSIONS: Overall, the aortic expression pattern of mechanosensitive genes seems to be spatially influenced by a hyperlipidemic diet and can be modified using colchicine-based therapy.PMID:36362692 | DOI:10.3390/jcm11216465
Source: Atherosclerosis - November 11, 2022 Category: Cardiology Authors: Konstantinos S Mylonas Panagiotis Sarantis Alkistis Kapelouzou Michalis V Karamouzis Emmanouil I Kapetanakis Konstantinos Kontzoglou Dimitrios C Iliopoulos Nikolaos Nikiteas Dimitrios Schizas Source Type: research
Human Wharton's Jelly-derived mesenchymal stem cells prevent acetaminophen-induced liver injury in a mouse model unlike human dermal fibroblasts
Arch Toxicol. 2022 Sep 4. doi: 10.1007/s00204-022-03372-5. Online ahead of print.ABSTRACTThe persistence of hepatotoxicity induced by N-acetyl-para-aminophenol (Acetaminophen or Paracetamol, abbreviated as APAP) as the most common cause of acute liver failure in the United States, despite the availability of N-acetylcysteine, illustrates the clinical relevance of additional therapeutic approaches. While human mesenchymal stem cells (MSCs) have shown protection in mouse models of liver injury, the MSCs used are generally not cleared for human use and it is unclear whether these effects are due to xenotransplantation. Here w...
Source: Archives of Toxicology - September 4, 2022 Category: Toxicology Authors: David S Umbaugh Rupal P Soder Nga T Nguyen Olamide Adelusi Dakota R Robarts Ben Woolbright Luqi Duan Sunil Abhyankar Buddhadeb Dawn Udayan Apte Hartmut Jaeschke Anup Ramachandran Source Type: research
Pyrogallol enhances therapeutic effect of human umbilical cord mesenchymal stem cells against LPS-mediated inflammation and lung injury via activation of Nrf2/HO-1 signaling
Free Radic Biol Med. 2022 Aug 23:S0891-5849(22)00558-5. doi: 10.1016/j.freeradbiomed.2022.08.030. Online ahead of print.ABSTRACTThe main challenges in clinical applications of mesenchymal stem cells (MSCs) are attributed to their heterogeneity. It is believed that preconditioning of MSCs with active compounds may enhance the expression of potentially therapeutic molecules and thus achieve stable and effective therapeutic outcomes. In the present study, we investigated the mechanism by which pyrogallol increased the therapeutic efficacy of human umbilical cord mesenchymal stem cells (hUCMSCs) against LPS-induced acute lung ...
Source: Free Radical Biology and Medicine - August 26, 2022 Category: Biology Authors: Yuehan Zhang Sushan Yang Zhenhua Qiu Li Huang Linyan Huang Yueyun Liang Xuanyu Liu Maosheng Wang Beixian Zhou Source Type: research
The protective effect of N-acetylcysteine on antimycin A-induced respiratory chain deficiency in mesenchymal stem cells
Chem Biol Interact. 2022 Apr 14:109937. doi: 10.1016/j.cbi.2022.109937. Online ahead of print.ABSTRACTTransplantation of mesenchymal stem cells (MSCs) is an effective treatment in tissue injuries though it is limited due to the early death of stem cells within the first few days. The main reason could be a deficiency in the respiratory chain of injured tissues which is linked to the oxidative stress (OS) and disruption of energy metabolism. The disruption in energy metabolism and OS both inhibit the homing of stem cells in the hypoxic micro-environment, however on other hand, the key functions of stem cells are mainly regu...
Source: Chemico-Biological Interactions - April 17, 2022 Category: Molecular Biology Authors: Abolfazl Barzegari Yadollah Omidi Rebecca Landon Virginie Gueguen Sepideh Parvizpour Anne Meddahi-Pell é Fani Anagnostou Graciela Pavon-Djavid Source Type: research
Mesenchymal stem cells protect against acetaminophen hepatotoxicity by secreting regenerative cytokine hepatocyte growth factor
CONCLUSIONS: MSCs are comparable to NAC against APAP-induced liver failure by secreting HGF with less regenerative retardation concerns, thus facilitating the application of MSCs in clinical therapy for APAP liver failure.PMID:35246254 | DOI:10.1186/s13287-022-02754-x
Source: Cell Research - March 5, 2022 Category: Cytology Authors: Ping Wang Yan Cui Jing Wang Donghua Liu Yue Tian Kai Liu Xue Wang Lin Liu Yu He Yufeng Pei Li Li Liying Sun Zhijun Zhu Dehua Chang Jidong Jia Hong You Source Type: research
Impaired dental implant osseointegration in rat with streptozotocin-induced diabetes
CONCLUSION: In diabetes, high-glucose-induced oxidative stress downregulates proliferation and calcification of BMMSCs, impairing osseointegration and leading to implant failure.PMID:35037248 | DOI:10.1111/jre.12972
Source: Cell Research - January 17, 2022 Category: Cytology Authors: Natsumi Saito Risako Mikami Koji Mizutani Kohei Takeda Hiromi Kominato Daisuke Kido Yuichi Ikeda Prima Buranasin Keita Nakagawa Shu Takemura Takeshi Ueno Keiichi Hosaka Takao Hanawa Tamayuki Shinomura Takanori Iwata Source Type: research
Human dental pulp stem cells and hormesis
Ageing Res Rev. 2021 Dec 7:101540. doi: 10.1016/j.arr.2021.101540. Online ahead of print.ABSTRACTThis paper represents the first assessment of hormetic dose responses by human dental pulp stem cells (hDPSCs) with particular emphasis on cell renewal (proliferation) and differentiation. Hormetic dose responses were commonly reported in this model, encompassing a broad range of chemicals, including principally pharmaceuticals (e.g., metformin and artemisinin), dietary supplements/extracts from medicinal plants (e.g., berberine, N-acetyl-L-cysteine, and ginsenoside Rg1) and endogenous agents (e.g., ATP, TNF-α). The paper asse...
Source: Ageing Research Reviews - December 10, 2021 Category: Genetics & Stem Cells Authors: Edward J Calabrese Evgenios Agathokleous Gaurav Dhawan Rachna Kapoor Vittorio Calabrese Source Type: research
