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Drug: Acetic Acid

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Total 4747 results found since Jan 2013.

Targeted metabolomics analysis for serum Helicobacter pylori -positive based on LC-MS/MS
CONCLUSIONS: This study shows that H. pylori has an impact on human metabolism. Not only a variety of metabolites have significant changes, but also metabolic pathways are abnormal, which may be the reason for the high risk of H. pylori causing gastric cancer.PMID:36898359 | DOI:10.1002/bmc.5622
Source: Biomedical Chromatography : BMC - March 10, 2023 Category: Biomedical Science Authors: Jin Wang Jiaying Shan Yaosheng Zhang Yu Shi Dongdong Lu Yichao Wu Xi Ping Guo Han Liu Jie Wang Naidong Hu Source Type: research

Design, synthesis, structural characterization by IR, 1H, 13C, 15N, 2D‐NMR, X‐ray diffraction and evaluation of a new class of Phenylaminoacetic acid benzylidene hydrazines as pfENR inhibitors
Abstract Recent studies have revealed that plasmodial enoyl‐ACP reductase (pfENR, FabI), one of the crucial enzymes in the plasmodial type II fatty acid synthesis II (FAS II) pathway, is a promising target for liver stage malaria infections. Hence, pfENR inhibitors have the potential to be used as causal malarial prophylactic agents. In this paper we report the design, synthesis, structural characterization and evaluation of a new class of pfENR inhibitors. The search for inhibitors began with a virtual screen of the iResearch database by molecular docking. Hits obtained from the virtual screen were ranked according to t...
Source: Chemical Biology and Drug Design - February 1, 2013 Category: Biology Authors: Ramanuj P Samal, Vijay M Khedkar, Raghuvir R S Pissurlenkar, Angela Gono Bwalya, Deniz Tasdemir, Ramesh A Joshi, P R Rajamohanan, V G Puranik, Evans C Coutinho Tags: Research Article Source Type: research

Anti-inflammatory and immunosuppressive activities of 1,3-dicyclopentyl-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylic acid diethyl ester (ZL-5015).
In conclusion, our study demonstrates that the tetrahydropyrimidine derivative, ZL-5015, has both anti-inflammatory and immunosuppressive activities, although its potency is not satisfactory. Therefore ZL-5015 should be considered as a lead compound for further structural modification in the continuing search for novel and effective drugs in this area. PMID: 23791971 [PubMed - as supplied by publisher]
Source: International Immunopharmacology - June 18, 2013 Category: Allergy & Immunology Authors: Lun Y, Xia H, Zhang Q, Yu C, Chen N, Li X, Liu S, Lei L Tags: Int Immunopharmacol Source Type: research

Real-time metabolic monitoring with proton transfer reaction mass spectrometry
We analysed the time evolution of several volatile organic compounds formed by the catabolism of ingested isotope-labelled ethanol using real-time breath gas analysis with proton-transfer-reaction mass spectrometry. Isotope labelling allowed distinguishing the emerging volatile metabolites from their naturally occurring, highly abundant counterparts in the human breath. Due to an extremely low detection limit of the employed technologies in the parts per trillion per volume range, it was possible to detect the emerging metabolic products in exhaled breath within ∼10 min after oral ingestion of isotope-labelled eth...
Source: Journal of Breath Research - August 19, 2013 Category: Mental Illness Authors: Klaus Winkler, Jens Herbig and Ingrid Kohl Source Type: research

The Auxin Response Factor Transcription Factor Family in Soybean: Genome-Wide Identification and Expression Analyses During Development and Water Stress
In plants, the auxin response factor (ARF) transcription factors play important roles in regulating diverse biological processes, including development, growth, cell division and responses to environmental stimuli. An exhaustive search of soybean genome revealed 51 GmARFs, many of which were formed by genome duplications. The typical GmARFs (43 members) contain a DNA-binding domain, an ARF domain and an auxin/indole acetic acid (AUX/IAA) dimerization domain, whereas the remaining eight members lack the dimerization domain. Phylogenetic analysis of the ARFs from soybean and Arabidopsis revealed both similarity and divergenc...
Source: DNA Research - October 3, 2013 Category: Genetics & Stem Cells Authors: Van Ha, C., Le, D. T., Nishiyama, R., Watanabe, Y., Sulieman, S., Tran, U. T., Mochida, K., Van Dong, N., Yamaguchi-Shinozaki, K., Shinozaki, K., Tran, L.-S. P. Tags: Full papers Source Type: research

3D QSAR studies based in silico screening of 4,5,6-triphenyl-1,2,3,4-tetrahydropyrimidine analogs for anti-inflammatory activity.
Abstract The 3D QSAR studies based on generation of common pharmacophore hypotheses (CPHs) were performed separately for the series of 1,2,3,4-tetrahydropyrimidin-5-yl-acetic acid and 2-(4-sulfonylphenyl)pyrimidine analogs for their in-vivo anti-inflammatory activity and in-vitro COX-2 inhibitory activity respectively. The main idea of selecting two different series was to develop two 3D QSAR models for same scaffold (1,2,3,4-tetrahydropyrimidine/pyrimidine) for same target, but with different aspects of activity. The aim of study was to screen designed compounds and select new compounds with increased COX-2 selec...
Source: European Journal of Medicinal Chemistry - December 25, 2013 Category: Chemistry Authors: Lokwani DK, Mokale SN, Shinde DB Tags: Eur J Med Chem Source Type: research

Formic Acid and Acetic Acid Induce a Programmed Cell Death in Pathogenic Candida Species.
In conclusion, our results show that a low concentration of formic acid induces apoptosis-like programmed cell death in the Candida yeast and has a minimal effect on the survivability of mammalian cells, suggesting potential applications in the treatment of these infections. PMID: 24752490 [PubMed - as supplied by publisher]
Source: Current Microbiology - April 22, 2014 Category: Microbiology Authors: Lastauskienė E, Zinkevičienė A, Girkontaitė I, Kaunietis A, Kvedarienė V Tags: Curr Microbiol Source Type: research

Purification and characterization of a novel antimicrobial peptide from sheep reproductive tract.
Abstract A novel antimicrobial peptide, SRTAP-40 has been purified and characterized from sheep reproductive tract. The isolation procedure entailed acetic acid extraction, gel filtration chromatography, and HPLC. SRTAP-40 is composed of 40 amino acid residues with a MW of 4,820.47 Da from MALDI-TOF-MS. Its N-terminal sequence was AYVLDEPKP. SRTAP-40 cDNA was cloned by 3'-RACE. SRTAP-40 showed activity against E. coli Staphylococcus aureus, Streptococcus sp. and, Candida albicans with MIC values of 12, 12, 24, 6 μg/ml, respectively. By BLAST search, SRTAP-40 had no significant similarity to any known peptide. ...
Source: Biotechnology Letters - September 26, 2014 Category: Biotechnology Authors: Chen C, Ku C, Bo X, Wang X Tags: Biotechnol Lett Source Type: research

A new horizon on effects of alkalis metal ions during biomass pyrolysis based on density function theory study
Publication date: Available online 30 September 2014 Source:Journal of Analytical and Applied Pyrolysis Author(s): Yayun Zhang , Chao Liu In this work, a local pyrolytic model was brought up firstly to understand better the pyrolysis mechanism of cellulose with alkalis metal, and density function theory (DFT) was employed to investigate eight reaction pathways of β-d-glucopyranose. The mechanism of levoglucosan formation was based on the concerted mechanism, and that of other small molecular structures, such as hydroxyacetaldehyde acetol, acetic acid, etc., referred to in our previous work. All thermodynamic and kinetic...
Source: Journal of Analytical and Applied Pyrolysis - November 3, 2014 Category: Chemistry Source Type: research

Search for multi-functional catalysts: The electrooxidation of acetaldehyde on Platinum–Ruthenium–Rhodium electrodeposits
Publication date: 1 September 2011 Source:Journal of Electroanalytical Chemistry, Volume 660, Issue 1 Author(s): Gisele A.B. Mello , M. Janete Giz , Giuseppe A. Camara , Alexandre Crisci , Marian Chatenet Preliminary studies on the influence of Platinum–Rhodium electrodeposits upon the rate of acetaldehyde electrooxidation showed that Rhodium plays a dual role during electrooxidation, because it favors the break of C–C bonds whilst prevents the deliverance of oxygen-containing species, thus inhibiting the oxidation steps. Based on these results, in this work Platinum–Ruthenium and Platinum–Ruthenium–Rhodium ele...
Source: Journal of Electroanalytical Chemistry - November 10, 2014 Category: Chemistry Source Type: research

Murimonas intestini gen. nov., sp. nov., an acetate-producing bacterium of the family Lachnospiraceae isolated from the mouse gut.
Abstract Three strains of an anaerobic Gram-stain positive coccobacillus were isolated from the intestine of mice. These strains shared 100 % similarity in their 16S rRNA gene sequences, but were distantly related to any described members of the family Lachnospiraceae (<94 %). The most closely related species with standing names in nomenclature were Robinsoniella peoriensis, Ruminococcus gnavus, Blautia producta and Clostridium xylanolyticum. Phylogenetic relationships based on 16S rRNA analysis were confirmed by partial sequencing of hsp60 genes. The use of an in-house database search pipeline revealed that th...
Source: International Journal of Systematic and Evolutionary Microbiology - December 17, 2014 Category: Microbiology Authors: Kläring K, Just S, Lagkouvardos I, Hanske L, Haller D, Blaut M, Wenning M, Clavel T Tags: Int J Syst Evol Microbiol Source Type: research

Percutaneous ethanol injection or percutaneous acetic acid injection for early hepatocellular carcinoma.
CONCLUSIONS: PEI versus PAI did not differ significantly regarding benefits and harms in people with early HCC, but the two included trials had only a limited number of participants and one trial was judged a high risk of bias. Thus, the current evidence precludes us from making any firm conclusions.There was also insufficient evidence to determine whether PEI versus surgery (segmental liver resection) was more effective, because conclusions were based on a single randomised trial. While some data from this single trial suggested that PEI was safer, the high risk of bias and the lack of any confirmatory evidence make a rel...
Source: Cochrane Database of Systematic Reviews - January 26, 2015 Category: Journals (General) Authors: Weis S, Franke A, Berg T, Mössner J, Fleig WE, Schoppmeyer K Tags: Cochrane Database Syst Rev Source Type: research