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Total 126 results found since Jan 2013.

An in vitro evaluation of kratom (Mitragyna speciosa) on the catalytic activity of carboxylesterase 1 (CES1)
Chem Biol Interact. 2023 Sep 14:110715. doi: 10.1016/j.cbi.2023.110715. Online ahead of print.ABSTRACTKratom, (Mitragyna Speciosa Korth.) is a plant indigenous to Southeast Asia whose leaves are cultivated for a variety of medicinal purposes and mostly consumed as powders or tea in the United States. Kratom use has surged in popularity with the lay public and is currently being investigated for possible therapeutic benefits including as a treatment for opioid withdrawal due to the pharmacologic effects of its indole alkaloids. A wide array of psychoactive compounds are found in kratom, with mitragynine being the most abund...
Source: Chemico-Biological Interactions - September 16, 2023 Category: Molecular Biology Authors: Philip W Melchert Qingchen Zhang Sushobhan Mukhopadhyay Siva Rama Raju Kanumuri Christopher R McCurdy John S Markowitz Source Type: research

Epigenetic mechanism of therapeutic resistance and potential of epigenetic therapeutics in chemorefractory prostate cancer
Int Rev Cell Mol Biol. 2023;380:173-210. doi: 10.1016/bs.ircmb.2023.03.012. Epub 2023 Apr 12.ABSTRACTProstate cancer is the second leading cause of cancer death among men in the United States. Depending upon the histopathological subtypes of prostate cancers, various therapeutic options, such as androgen deprivation therapy (ADT), androgen receptor signaling inhibitors (ARSI), immunotherapy, and chemotherapy, are available to treat prostate cancer. While these therapeutics are effective in the initial stages during treatments, the tumors subsequently develop resistance to these therapies. Despite all the progress made so f...
Source: Mol Biol Cell - September 1, 2023 Category: Molecular Biology Authors: Priti Roy Kamaleshwar P Singh Source Type: research

Alteration of tumor suppressors changes the endometrial tumor spectrum
EMBO Mol Med. 2023 Aug 17:e18166. doi: 10.15252/emmm.202318166. Online ahead of print.ABSTRACTThe most common gynecological cancer in Europe and the United States is endometrial. Like most cancers, early-stage endometrial cancer has a more favorable prognosis, while high-grade, including endometrioid and nonendometrioid, has the worst prognosis. In endometrioid human tumors, the tumor suppressor genes PTEN and p53 (Trp53) are frequently altered or lost, as identified in datasets from The Cancer Genome Atlas. These suppressors' somatic mutations or loss of gene expression can lead to neoplastic development, tumor progressio...
Source: Molecular Medicine - August 17, 2023 Category: Molecular Biology Authors: Lindsey D Mayo Source Type: research

Separation and quantitative estimation of stereo-selective enantiomers of montelukast in pharmaceutical drug substance and tablets dosage forms by using stability-indicating normal phase-HPLC method
Chirality. 2023 Jul 17. doi: 10.1002/chir.23610. Online ahead of print.ABSTRACTMontelukast sodium (MLS) is a leukotriene receptor antagonist that relieves asthma, bronchospasm, allergic rhinitis, and urticaria. A simple, robust, and stability-indicating normal phase high-performance liquid chromatography method was developed to separate and quantitatively estimate the S-enantiomer of MLS. The chiral separation was achieved using USP L51 packing material along with a mobile phase consisting of a solvent mixture (n-hexane, ethanol, and propionic acid), a flow rate of 1.0 mL/min, a detection wavelength of 284 nm, a column tem...
Source: Chirality - July 18, 2023 Category: Molecular Biology Authors: Niroja Vadagam Sharath Babu Haridasyam Muvvala Venkatanarayana Narasimha S Lakka Sanjeeva R Chinnakadoori Source Type: research

A novel splice-site mutation in CHMP2B associated with frontotemporal dementia: The first report from China and literature review
CONCLUSION: This is the first case of CHMP2B variant-associated FTD reported in the Chinese population. The novel c.532-2A>T variant in the acceptor splice site of exon 6 retaining intron 5 was predicted to cause truncated protein and protein conformation changes. This discovery may expand the genetic and phenotypic spectrum of CHMP2B variant-associated FTD.PMID:37272767 | DOI:10.1002/mgg3.2222
Source: Molecular Medicine - June 5, 2023 Category: Molecular Biology Authors: Chang Li Ya Wen Mengqiu Zhao Yaye Wang Ping Li Liang Wang Shan Wang Source Type: research

Testing the Effects of Magnetic Hyperthermia in 2D Cell Culture
Methods Mol Biol. 2023;2645:251-261. doi: 10.1007/978-1-0716-3056-3_16.ABSTRACTMagnetic hyperthermia is an innovative thermal therapy for the treatment of solid malignancies. This treatment approach utilizes magnetic nanoparticles that are stimulated by alternating magnetic fields to induce temperature elevations in tumor tissue, resulting in cell death. Magnetic hyperthermia is clinically approved for treating glioblastoma in Europe and is undergoing clinical evaluation for prostate cancer in the United States. Numerous studies have also demonstrated efficacy in other cancers, however, and its potential utility extends fa...
Source: Mol Biol Cell - May 18, 2023 Category: Molecular Biology Authors: Gary Hannon Adriele Prina-Mello Source Type: research

A mini-review on ELISA-Based Diagnosis of Schistosomiasis
CONCLUSION: schistosomiasis is considered the most important helminthic disease in worldwide. therefore, it is important to of searching for and develops diagnostic methods based on serology to reduce morbidity and mortality caused by the disease.PMID:37143281 | DOI:10.2174/1566524023666230504140828
Source: Current Molecular Medicine - May 5, 2023 Category: Molecular Biology Authors: Michelli Dos Santos Mariana Teixeira de Faria Jonatas Oliveira da Silva Isadora Braga Gandra Anna Julia Ribeiro Kamila Alves Silva Lais Moreira Nogueira Juliana Martins Machado Reysla Maria da Silveira Mariano Ana Alice Maia Gon çalves Fernanda Ludolf Ma Source Type: research

Exploring the genetic diversity and population structure of upland cotton germplasm by iPBS-retrotransposons markers
CONCLUSIONS: This is the first investigation using an iPBS-retrotransposon marker system to examine the genetic diversity and population structure of upland cotton germplasm. The rich diversity found in upland cotton germplasm could be exploited as a genetic resource when developing breeding programs and could also help with efforts to breed cotton around the world. These findings also show the applicability and effectiveness of iPBS-retrotransposons for the molecular characterization of cotton germplasm.PMID:37031323 | DOI:10.1007/s11033-023-08399-0
Source: Molecular Biology Reports - April 8, 2023 Category: Molecular Biology Authors: Nurettin Baran Flavien Shimira Muhammad Azhar Nadeem Muhammad Tanveer Altaf Mehtap Andirman Faheem Shehzad Baloch Mefhar G ültekin Temiz Source Type: research