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Specialty: Neurology
Countries: Japan Health
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Total 219 results found since Jan 2013.
Intensive Blood Pressure Lowering in Patients with Moderate to Severe Grade Acute Cerebral Hemorrhage: Post Hoc Analysis of Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH)-2 Trial
Conclusions: Intensive SBP lowering reduced thefrequency of hematoma expansion but did not reduce the rate of death or disability in patients with moderate to severe grade ICH.Cerebrovasc Dis
Source: Cerebrovascular Diseases - June 25, 2020 Category: Neurology Source Type: research
Occurrence of Cerebrovascular Diseases Decreased after the Great East Japan Earthquake and Tsunami of 2011
Conclusions: The occurrence of CVDs in the flooded coastal areas did not increase in the year of the Great East Japan Earthquake and Tsunami; furthermore, it decreased for men according to the severity of flood damage in the subsequent years; this can be attributed to supportive activities for the tsunami victims and the migration of the population.Cerebrovasc Dis Extra 2020;10:105 –115
Source: Cerebrovascular Diseases Extra - October 8, 2020 Category: Neurology Source Type: research
The Clinical Characteristics and Treatment Considerations for Intracranial Aneurysms Associated With Middle Cerebral Artery Anomalies: A Systematic Review
Conclusions: The pathophysiological genesis of intracranial aneurysms associated with MCA anomalies is still obscure. The inflicted patients tend to have other concurrent cerebrovascular anomalies, which denotes that congenital defect in cerebrovascular development might play a role in this process. Most of the affected patients could experience a good recovery after treatment.
Source: Frontiers in Neurology - October 27, 2020 Category: Neurology Source Type: research
Recurrent Cerebral Venous Thrombosis Treated with Direct Oral Anticoagulants in a Japanese Man with Hereditary Protein C Deficiency
We herein report a case involving a 32-year-old Japanese man with recurrent cerebral venous thrombosis due to hereditary protein C deficiency. He was admitted to our hospital with impaired consciousness. Brain magnetic resonance imaging demonstrated high intensities diffusely along the bilateral sulci and magnetic resonance venography revealed left transverse sinus and superior sagittal sinus stenoses. His father had a history of cerebral infarction and venous thrombosis. The protein C activity level examined by chromogenic synthetic substrate assay was markedly reduced.
Source: Journal of Stroke and Cerebrovascular Diseases - October 29, 2020 Category: Neurology Authors: Kazuyuki Saito, Kazuyuki Ishii, Konosuke Furuta, Masaki Kobayashi, Yoshiaki Wada, Eriko Morishita Tags: Case Report Source Type: research
Reliability of the Modified Rankin Scale Assessment Using a Simplified Questionnaire in Japanese
We developed a Japanese version of the simplified modified Rankin Scale questionnaire, of which the agreement between patients or their family members and neurologists was verified in a previous single-center study. In the present study, the reliability of the questionnaire was evaluated in another hospital.
Source: Journal of Stroke and Cerebrovascular Diseases - December 4, 2020 Category: Neurology Authors: Kenichiro Yi, Yuichiro Inatomi, Makoto Nakajima, Toshiro Yonehara, Mitsuharu Ueda Source Type: research
Inner-Ear Symptom May Herald Basilar Artery Occlusion
A 75-year-old Japanese man suddenly experienced right cochlear and vestibular dysfunction. Basilar artery occlusion and silent right cerebellar infarction were identified 3 days later. These were treated with intravenous ozagrel (an antiplatelet agent) and edaravone, a free-radical scavenger. The patient did not develop cerebello-brainstem signs. His first sign most probably reflected a right labyrinthine artery occlusion that heralded, or occurred together with, the basilar artery occlusion. This case highlights the possibility that a sudden inner ear dysfunction may herald a basilar stroke. Clinicians should therefore in...
Source: Case Reports in Neurology - January 21, 2021 Category: Neurology Source Type: research
Hemichorea Neglect after Stroke
We report a case of a 74-year-old Japanese woman who, after left thalamic infarction, developed right hemichorea and its neglect. This rare finding was associated with ipsi- and contralateral brain perfusion changes, presumably reflecting de-afferentiation within the brain.Case Rep Neurol 2021;13:50 –52
Source: Case Reports in Neurology - January 28, 2021 Category: Neurology Source Type: research
Clinical Outcomes and Medical Costs of Hydration Therapy with Hydroxyethyl Starch (130/0.4) or Acute Single Infarction
Although a single infarction (SI) is typically predicted to have good outcomes, 20% –30% of SI patients experience secondary progressive motor deficits (PMD) occurring within a few days after SI onset, which often leads to severe disabilities.1 This disease type in lenticulostriate artery (LSA) is well known as branch atheromatous disease (BAD) in Japan.2 Neither evidence nor con sensus-based indications exist about how to prevent PMD2. Vascular risk factors, such as elevated haemoglobin A1c and blood pressure levels, as well as the characteristics of ischemic lesions, such as the size and location of the infarction, esp...
Source: Journal of Stroke and Cerebrovascular Diseases - March 10, 2021 Category: Neurology Authors: Ayaka Fujita, Masashi Matsuzaka, Norifumi Metoki, Joji Hagii, Hiroshi Shiroto, Manabu Iwata, Rina Tanaka, Eiichi Tsuda Source Type: research
The Genetic Basis of Moyamoya Disease
AbstractMoyamoya disease (MMD) is a rare cerebrovascular disease characterized by progressive spontaneous bilateral occlusion of the intracranial internal cerebral arteries (ICA) and their major branches with compensatory capillary collaterals resembling a “puff of smoke” (Japanese: Moyamoya) on cerebral angiography. These pathological alterations of the vessels are called Moyamoya arteriopathy or vasculopathy and a further distinction is made between primary and secondary MMD. Clinical presentation depends on age and population, with hemorrhage and ischemic infarcts in particular leading to severe neurological dysfun...
Source: Translational Stroke Research - January 18, 2022 Category: Neurology Source Type: research
Subcortical infarction in a young adult with Hunter syndrome
Hunter syndrome (mucopolysaccharidosis type II, MPS II) is an X-linked lysosomal storage disease caused by deficiency of iduronate-2-sulfatase. Recently, stroke caused by embolization with Hunter syndrome has been reported. Here, we report the case of a 23-year-old Japanese man with Hunter syndrome who developed subcortical infarction by the mechanism similar to branch atheromatous disease (BAD).
Source: Brain and Development - February 3, 2022 Category: Neurology Authors: Motoya Kimura, Yoshiteru Azuma, Soutarou Taguchi, Mizuki Takagi, Hiromitsu Mori, Yasuto Shimomura, Jun-Ichi Niwa, Manabu Doyu, Akihisa Okumura Tags: Case Report Source Type: research
Impact of prior antiplatelet therapy on outcomes of endovascular therapy for acute ischemic stroke with large vessel occlusion: Sub-analysis of the RESCUE-Japan Registry 2
The impact of prior antiplatelet therapy (APT) on clinical outcomes of endovascular therapy (EVT) for large vessel occlusion (LVO) on clinical outcomes is uncertain. We explored the associations between prior APT and in-hospital and 90-day outcomes in a real-world setting.
Source: Journal of the Neurological Sciences - May 10, 2022 Category: Neurology Authors: Satoru Fujiwara, Nobuyuki Sakai, Hirotoshi Imamura, Nobuyuki Ohara, Kanta Tanaka, Hiroshi Yamagami, Yasushi Matsumoto, Masataka Takeuchi, Kazutaka Uchida, Shinichi Yoshimura, Takeshi Morimoto, RESCUE-Japan Registry 2 Investigators Source Type: research
Moyamoya Disease Associated with a Deficiency of Complement Component 6
Complement component 6 (C6) deficiency is a very rare genetic defect that leads to significantly diminished synthesis, secretion, or function of C6. In the current report, we demonstrate a previously undescribed, homozygous missense mutation in exon 17 of the C6 gene (c.2545A>G p.Arg849Gly) in a 35-year-old Japanese woman with moyamoya disease and extremely low levels of CH50 (
Source: Journal of Stroke and Cerebrovascular Diseases - June 16, 2022 Category: Neurology Authors: Masaru Kato, Yuki Kudo, Masanao Hatase, Naohisa Tsuchida, Shuhei Takeyama, Taku Sugiyama, Miki Fujimura, Ichiro Yabe, Hiroshi Tsujimoto, Yasuo Fukumori, Norimitsu Inoue, Tatsuya Atsumi Source Type: research
Trends in surgical procedures for spontaneous intracerebral hemorrhage in Japan
Minimally invasive surgery for spontaneous intracerebral hemorrhage (ICH) has become increasingly popular in recent years. However, there are no reports on the recent trends in surgical procedures for spontaneous ICH. To investigate current trends in surgical methods for spontaneous ICH using a nationwide inpatient database from Japan.
Source: Journal of Stroke and Cerebrovascular Diseases - July 28, 2022 Category: Neurology Authors: Shigeyuki Tahara, Yujiro Hattori, Shotaro Aso, Kazuaki Uda, Ryosuke Kumazawa, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga, Akio Morita Source Type: research
Safety of Apixaban Monotherapy for Non-Valvular Atrial Fibrillation-Related Acute Stroke with Intra-/Extracranial Artery Stenosis
Conclusion: Apixaban monotherapy appears safe for the prevention of further adverse events in the Stenosis group patients similar to the No stenosis group patients. Concomitant use of an antiplatelet might not be favorable in patients with stenosis.Cerebrovasc Dis
Source: Cerebrovascular Diseases - October 12, 2022 Category: Neurology Source Type: research
MR vessel wall enhancement in a pediatric focal cerebral arteriopathy
We describe the case of a 7-year-old Japanese girl with right hemiplegia and dysarthria for 3 days. Brain MRI showed acute infarct in the left basal ganglia, and MRA and conventional cerebral angiogram detected vascular stenosis in the left distal internal carotid artery, left M1 and A1 segments.
Source: Brain and Development - February 17, 2023 Category: Neurology Authors: Shoko YOSHII, Rina FUKUI, Shinya HATTORI, Ryo YAMAGUCHI, Ryo FUJIMOTO, Hiromi AOYAMA, Taku OMATA Tags: Case Report Source Type: research
