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Fight Aging! Newsletter, August 8th 2022
In conclusion, aging research will benefit from a better definition of how specific regulators map onto age-dependent change, considered on a phenotype-by-phenotype basis. Resolving some of these key questions will shed more light on how tractable (or intractable) the biology of aging is. Does Acarbose Extend Life in Short Lived Species via Gut Microbiome Changes? https://www.fightaging.org/archives/2022/08/does-acarbose-extend-life-in-short-lived-species-via-gut-microbiome-changes/ Acarbose is one of a few diabetes medications shown to modestly slow aging in short-lived species. Researchers here take a ...
Source: Fight Aging! - August 7, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Nocturnal hypertension : Something Important is being cooked in the hypertensive world !
Some physics: Why is blood under pressure?  In perfect vascular climatic conditions, the human circulatory system is comparable to a smooth flowing river irrigating 100 trillion cells, traversing many kilometers of the capillary network, to the far away tissue bed. One major difference in the river analogy is, that in human biology, the entire blood has to return back to the heart in about 30 seconds. (The fact that the venous system does this in style with near-zero pressure head is the greatest wonder in circulatory physiology) The force per unit area, that drives the blood is the blood pressure. It is expressed...
Source: Dr.S.Venkatesan MD - June 12, 2022 Category: Cardiology Authors: dr s venkatesan Tags: Hypertension systemic hypertension acc aha esc hypertension guidelines dippers non dippers melatonin for nocturnal hypertension night time bp reverse dipper Source Type: blogs

Social jetlag among Japanese adolescents: Association with irritable mood, daytime sleepiness, fatigue, and poor academic performance
Chronobiol Int. 2021 Nov 3:1-12. doi: 10.1080/07420528.2021.1996388. Online ahead of print.ABSTRACTSocial jetlag, a form of circadian misalignment, has been suggested to induce several clinical symptoms such as mental/physical health problems. However, evidence on the association of social jetlag with general daytime functioning (e.g., school life) is limited. This cross-sectional study aimed to 1) estimate the distribution of social jetlag exceeding one hour and 2) comprehensively explore the associations between social jetlag and irritable mood, daytime sleepiness, and poor academic performance among Japanese adolescents...
Source: Chronobiology International - November 4, 2021 Category: Biology Authors: Norihisa Tamura Yoko Komada Yuichi Inoue Hideki Tanaka Source Type: research

Recent advances in management of COVID-19: A review
In this study, selected novel pharmacological agents for the possible treatment of COVID-19 will be discussed. Point of discussion will cover mechanism of action, supporting evidence for safety and efficacy and reached stage in development. Drugs were classified into three classes according to the phase of viral life cycle they target. Phase I, the early infective phase, relies on supportive care and symptomatic treatment as needed. In phase II, the pulmonary phase, treatment aims at inhibiting viral entry or replication. Drugs used during this phase are famotidine, monoclonal antibodies, nanobodies, ivermectin, remdesivir...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 6, 2021 Category: Drugs & Pharmacology Authors: Soraya Mouffak Qamar Shubbar Ekram Saleh Raafat El-Awady Source Type: research

Association between Dietary Melatonin Intake and Total and Cause-Specific Mortality in Japanese Adults in the Takayama Study
Am J Epidemiol. 2021 Aug 13:kwab213. doi: 10.1093/aje/kwab213. Online ahead of print.ABSTRACTPotential health benefits of melatonin have been suggested. Although melatonin is present in various foods, little is known about the health effects of dietary melatonin intake. We estimated habitual dietary melatonin intake and examined its association with total and cause-specific mortality in a population-based cohort study in Japan. Study subjects included 13,355 men and 15,724 women, aged 35 years and older. They responded to a self-administered questionnaire in 1992. Their diets were assessed via a food-frequency questionnair...
Source: Am J Epidemiol - August 13, 2021 Category: Epidemiology Authors: Chisato Nagata Keiko Wada Michiyo Yamakawa Yuma Nakashima Sachi Koda Takahiro Uji Sakiko Onuma Shino Oba Yuuske Maruyama Atsuhiko Hattori Source Type: research

Evaluation of salivary melatonin concentrations as a circadian phase maker of morning awakening and their association with depressive mood in postpartum mothers
This study aimed to evaluate whether salivary melatonin concentration at awakening can identify misalignment between awakening time and the biological clock system, which might be associated with depressive mood in some mothers. Ninety-eight healthy mothers who were currently the primary parental caregivers were recruited at 1 month after delivery. All mothers completed the Edinburgh Postnatal Depression Scale (EPDS) and wore an actigraphy watch at home for 3 consecutive days to determine nocturnal sleep variables. While wearing the actigraphy watch, they also collected saliva samples during the awakening period for a mela...
Source: Chronobiology International - June 8, 2021 Category: Biology Authors: Naoko Kudo Hitomi Shinohara Satoko Kagabu Hideya Kodama Source Type: research

Single Nucleotide Polymorphisms and the Central Nervous System: Potential Biomarkers in Identifying Suicide Risk
Conclusion Point of care testing (POC) with immediately available results becomes more important, especially in young adults in whom an escalation in the number and severity of self-destructive behaviors is increasingly associated with fatal outcomes. Other populations of concern would be the active duty military and veterans where suicides are also steadily rising and warrant close monitoring and predictive testing when available. At the very least, it behooves us as clinicians and scientists to further explore and clearly establish the relationship between SNPs and suicidal behaviors. Disclaimer The views expressed here ...
Source: Innovations in Clinical Neuroscience - June 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: biomarkers Current Issue Drug Development Genetics Psychiatry Review Suicidality CNS CYP2C19 CYP2D6 pharmacogenomics Single nucleotide polymorphism Single nucleotide polymorphisms SNP SNPs suicide risk Source Type: research