Single Nucleotide Polymorphisms and the Central Nervous System: Potential Biomarkers in Identifying Suicide Risk

Conclusion Point of care testing (POC) with immediately available results becomes more important, especially in young adults in whom an escalation in the number and severity of self-destructive behaviors is increasingly associated with fatal outcomes. Other populations of concern would be the active duty military and veterans where suicides are also steadily rising and warrant close monitoring and predictive testing when available. At the very least, it behooves us as clinicians and scientists to further explore and clearly establish the relationship between SNPs and suicidal behaviors. Disclaimer The views expressed here are solely those of the authors and are not to be construed as official or representing those of the Department of the Army or the Department of Defense. References Ingelman-Sundberg M, Persson A, Jukic MM. Polymorphic expression of CYP2C19 and CYP2D6 in the developing and adult human brain causing variability in cognition, risk for depression and suicide: the search for the endogenous substrates. Pharmacogenomics. 2014;15(15):1841–1844. Sankararaman S, Mallick S, Dannemann M, et al. The genomic landscape of Neanderthal ancestry in present-day humans. Nature. 2014;507(7492):354–357. Ferugson CS, Tyndale RF. Cytochrome P450 enzymes in the brain: emerging evidence of biological significance. Trends Pharmacol Sci. 2011;32(12):708–714. Yarlagadda A, Clayton AH. Blood brain barrier: the role of pyridoxine. Psychiatry (Edgmont). 2007;4(8):58–60. Ingelman-...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: biomarkers Current Issue Drug Development Genetics Psychiatry Review Suicidality CNS CYP2C19 CYP2D6 pharmacogenomics Single nucleotide polymorphism Single nucleotide polymorphisms SNP SNPs suicide risk Source Type: research