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Total 100 results found since Jan 2013.
Understanding the reactivity and selectivity of Diels –Alder reactions involving furans
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Tiago Vinicius Alves, Israel Fern ández The origins of the reactivity andendo/exo selectivity of the Diels –Alder cycloaddition reactions involving furan and substituted furans as dienes have been computationally explored. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - September 12, 2023 Category: Molecular Biology Authors: Tiago Vinicius Alves Source Type: research
Understanding the reactivity and selectivity of Diels-Alder reactions involving furans
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Tiago Vinicius Vinicius Alves, Israel Fernandez The reactivity and endo/exo selectivity of the Diels-Alder cycloaddition reactions involving furan and substituted furans as dienes have been computationally explored. In comparison to cyclopentadiene, it is found that furan... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - September 7, 2023 Category: Molecular Biology Authors: Tiago Vinicius Vinicius Alves Source Type: research
Formulation and evaluation of anion transporters in nanostructured lipid carriers
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Daniel Alonso-Carrillo, Israel Carreira-Barral, Marcin Mielczarek, Andrea Sancho-Medina, Enara Herran, Claudia Vairo, Angel Del Pozo, Iris Luzuriaga Borrajo, Nerea Lazcanoiturburu, Oihane Ibarrola, Sara Ponce, Maria Villar-Vidal, Maria Garcia-Valverde, Roberto Quesada Six novel click-tambjamines (1-6) bearing an alkyl chain of varying length linked to the imine moiety have been formulated in nanostructured lipid carriers (NLCs) to evaluate their transmembrane anion transport... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - August 29, 2023 Category: Molecular Biology Authors: Daniel Alonso-Carrillo Source Type: research
An immune-protein score combining TRAIL, IP-10 and CRP for predicting severe COVID-19 disease
This study reports derivation of an algorithm that integrates the host levels of TRAIL, IP-10, and CRP into a single numeric score that is an early indicator of severe outcome for COVID-19 patients and can identify patients at-risk to deteriorate. 394 COVID-19 patients were eligible; 29% meeting a severe outcome (intensive care unit admission/non-invasive or invasive ventilation/death). The score's area under the receiver operating characteristic curve (AUC) was 0.86, superior to IL-6 (AUC 0.77; p = 0.033) and CRP (AUC 0.78; p < 0.001). Likelihood of severe outcome increased significantly (p < 0.001) with higher scor...
Source: Cytokine - June 16, 2023 Category: Molecular Biology Authors: Niv Samuel Mastboim Alon Angel Oded Shaham Tahel Ilan Ber Roy Navon Einav Simon Michal Rosenberg Yael Israeli Mary Hainrichson Noa Avni Eran Reiner Paul Feigin Kfir Oved Boaz Tadmor Pierre Singer Ilya Kagan Shaul Lev Dror Diker Amir Jarjou'I Ramzi Kurd El Source Type: research
Effects of the Rho GTPase-activating toxin CNF1 on fibroblasts derived from Rett syndrome patients: A pilot study
J Cell Mol Med. 2023 Apr 20. doi: 10.1111/jcmm.17624. Online ahead of print.ABSTRACTThe bacterial product CNF1, through its action on the Rho GTPases, is emerging as a modulator of crucial signalling pathways involved in selected neurological diseases characterized by mitochondrial dysfunctions. Mitochondrial impairment has been hypothesized to have a key role in paramount mechanisms underlying Rett syndrome (RTT), a severe neurologic rare disorder. CNF1 has been already reported to have beneficial effects in mouse models of RTT. Using human RTT fibroblasts from four patients carrying different mutations, as a reliable dis...
Source: J Cell Mol Med - April 20, 2023 Category: Molecular Biology Authors: Camilla Cittadini Elena Angela Pia Germinario Zaira Maroccia Livia Cosentino Valeria Maselli Lucrezia Gambardella Massimo Giambenedetti Marco Guidotti Sara Travaglione Chiara Fallerini Alessandra Renieri David Israel Escobar Marcillo Laura Ricceri Paola F Source Type: research
Association of endoplasmic reticulum associated degradation (ERAD) with the transmission of Liberibacter solanacearum by its psyllid vector
Insect Mol Biol. 2023 Apr 15. doi: 10.1111/imb.12842. Online ahead of print.ABSTRACTCandidatus Liberibacter solanacearum (CLso) is a complex of gram negative plant pathogenic and fastidious bacterial haplotypes restricted to the phloem and transmitted by several psyllid species. In Israel, the carrot psyllid Bactericera trigonica transmits CLso haplotype D in a persistent and propagative manner and causes the carrot yellows disease, inflicting significant economic losses in many countries. Understanding the transmission of CLso is fundamental to devising sustainable management strategies. Persistent transmission of vector-...
Source: Mol Biol Cell - April 15, 2023 Category: Molecular Biology Authors: Ola Jassar Murad Ghanim Source Type: research
Computational studies of potential antiviral compounds from some selected Nigerian medicinal plants against SARS-CoV-2 proteins
Inform Med Unlocked. 2023;38:101230. doi: 10.1016/j.imu.2023.101230. Epub 2023 Mar 22.ABSTRACTThe challenges posed by COVID-19's emergence have led to a search for its therapies. There is no cure for COVID-19 infection yet, but there is significant progress in vaccine formulation for prophylaxis and drug development (such as Paxlovid) for high-risk patients. As a contribution to the ongoing quest for solutions, this study shows potent phytocompounds identification as inhibitors of SARS-CoV-2 targets using in silico methods. We used virtual screening, molecular docking, and molecular dynamics (MD) simulations to investigate...
Source: Molecular Medicine - March 28, 2023 Category: Molecular Biology Authors: Raymond C Ibeh Gavin C Ikechukwu Chinonyerem J Ukweni Israel C Omekara Amanda U Ezirim Favour N Ujowundu Ebere O Eziefuna Callistus I Iheme Sunday O Oyedemi Hezekiel M Kumalo Umar Ndagi Monsurat M Lawal Source Type: research
SPECT at the speed of PET: a feasibility study of CZT-based whole-body SPECT/CT in the post < sup > 177 < /sup > Lu-DOTATATE and < sup > 177 < /sup > Lu-PSMA617 setting
CONCLUSION: Fast acquisition of whole-body post-therapy SPECT/CT is feasible with the new StarGuide system. Short scanning time improves the patients' clinical experience and compliance which may lead to increased adoption of post-therapy SPECT. This opens the possibility to offer imaged-based treatment response assessment and personalized dosimetry to patients referred for targeted radionuclide therapies.PMID:36869177 | DOI:10.1007/s00259-023-06176-6
Source: Molecular Medicine - March 3, 2023 Category: Molecular Biology Authors: Hong Song Valentina Ferri Heying Duan Carina Mari Aparici Guido Davidzon Benjamin L Franc Farshad Moradi Judy Nguyen Jagruti Shah Andrei Iagaru Source Type: research
Cytokine Patterns in COVID-19 Patients: Which Cytokines Predict Mortality and Which Protect Against?
Conclusions: Proinflammatory cytokines predict clinical severity, lung fibrosis, and mortality in COVID-19 patients. High concentrations of TGF-β, CXCL-10, IL-10, IL-6, and TNF-α are correlated to severity and lung injury. However, certain cytokines have protective effects and higher levels of these cytokines increase survival levels and lower lung damage. High levels of INF-γ, IL-7, MMP-7, and IGF-1 have protection probabilities against lung injury and severity.PMID:36286038 | DOI:10.3390/cimb44100323
Source: Current Issues in Molecular Biology - October 26, 2022 Category: Molecular Biology Authors: Maamoun Basheer Elias Saad Majd Kananeh Layyous Asad Osama Khayat Anan Badarne Zaki Abdo Nada Arraf Faris Milhem Tamara Bassal Mariana Boulos Nimer Assy Source Type: research
