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Specialty: Neurology
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Total 198 results found since Jan 2013.

Hyperintense Vessels, Collateralization, and Functional Outcome in Patients With Stroke Receiving Endovascular Treatment Clinical Sciences
Conclusions—Low FHV-ASPECTS is associated with both better collateral status and better 3-month functional outcome in acute stroke patients with M1 vessel occlusion.
Source: Stroke - February 26, 2018 Category: Neurology Authors: Alexander H. Nave, Anna Kufner, Philipp Bucke, Eberhard Siebert, Stefan Kliesch, Ulrike Grittner, Hansȷorg Bazner, Thomas Liebig, Matthias Endres, Jochen B. Fiebach, Christian H. Nolte, Martin Ebinger, Hans Henkes Tags: Angiography, Magnetic Resonance Imaging (MRI), Prognosis, Revascularization, Ischemic Stroke Original Contributions Source Type: research

Stroke unit care and trends of in‐hospital mortality for stroke in Germany 2005–2010
ConclusionsThe earlier stroke unit implementations might represent rather ‘formal’ inceptions in experienced hospitals with preexisting appropriate stroke care, whereas late implementations seem to have caused extra improvements. Overall, stroke patients are more likely to survive when admitted to an stroke unit‐providing hospital. A more stringent assignment of acute stroke patients to stroke unit‐providing hospitals could possibly further reduce stroke mortality in Germany.
Source: International Journal of Stroke - November 10, 2013 Category: Neurology Authors: Ulrike Nimptsch, Thomas Mansky Tags: Research Source Type: research

Validating the TeleStroke Mimic Score Clinical Sciences
We report the area under the curve in receiver-operating characteristic curve analysis with 95% confidence interval for our previously derived TM score in which lower TM scores correspond with a higher likelihood of being a stroke mimic.Results—Based on final diagnosis at the end of the telestroke consultation, there were 630 of 1930 (32.6%) stroke mimics in the external validation cohort. All 6 variables included in the score were significantly different between patients with ischemic cerebrovascular disease versus stroke mimics. The TM score performed well (area under curve, 0.72; 95% confidence interval, 0.70–0.73; P
Source: Stroke - February 26, 2018 Category: Neurology Authors: Syed F. Ali, Gordian J. Hubert, Jeffrey A. Switzer, Jennifer J. Majersik, Roland Backhaus, L. Wylie Shepard, Kishore Vedala, Lee H. Schwamm Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research

Machine Learning –Based Identification of Target Groups for Thrombectomy in Acute Stroke
AbstractWhether endovascular thrombectomy (EVT) improves functional outcome in patients with large-vessel occlusion (LVO) stroke that do not comply with inclusion criteria of randomized controlled trials (RCTs) but that are considered for EVT in clinical practice is uncertain. We aimed to systematically identify patients with LVO stroke underrepresented in RCTs who might benefit from EVT. Following the premises that (i) patients without reperfusion after EVT represent a non-treated control group and (ii) the level of reperfusion affects outcome in patients with benefit from EVT but not in patients without treatment benefit...
Source: Translational Stroke Research - June 7, 2022 Category: Neurology Source Type: research

Electrocardiographic RR Interval Dynamic Analysis to Identify Acute Stroke Patients at High Risk for Atrial Fibrillation Episodes During Stroke Unit Admission
AbstractPatients at short-term risk of paroxysmal atrial fibrillation (PAF) often exhibit increased RR interval variability during sinus rhythm. We studied if RR dynamic analysis, applied in the first hours after stroke unit (SU) admission, identified acute ischemic stroke patients at higher risk for subsequent PAF episodes detected within the SU hospitalization. Acute ischemic stroke patients underwent continuous cardiac monitoring (CCM) using standard bedside monitors immediately after SU admission. The CCM tracks from the first 48  h were analyzed using a telemedicine service (SRA clinic, Apoplex Medical, Germany). Bas...
Source: Translational Stroke Research - July 3, 2018 Category: Neurology Source Type: research

The German version of the Functional Walking Categories (FWC): translation and initial validation.
CONCLUSIONS: The German FWC offers a reasonable tool for measuring community ambulation on participation level. However, a user manual seems to be helpful. PMID: 30346912 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - October 22, 2018 Category: Neurology Authors: Klotz SGR, Petersen-Ewert C, Ketels G, Scherer M, Barzel A Tags: Top Stroke Rehabil Source Type: research

Certification criteria for stroke units in Germany : Update 2018.
This article describes the revised criteria for certified stroke units (SU) in Germany that will apply from 1 October 2018. Due to the high level of quality only minor adjustments and specifications were necessary in many places and the majority of criteria remained unchanged. For the first time a uniform personnel quota of ≥1.75 full-time staff per monitor bed is defined, which is a better reflection of the treatment reality. The evidence-based process of acute vascular imaging using computed tomography angiography (CTA) and alternatively magnetic resonance angiography (MRA) is now defined as a minimum rate of≥20 % ...
Source: Der Nervenarzt - October 29, 2018 Category: Neurology Authors: Nabavi DG, Koennecke HC, Ossenbrink M, Grau A, Busse O, die Stroke Unit Kommission, den Zertifizierungsausschuss der DSG, den Vorstand der DSG, den Zertifizierungsausschuss der DSG Tags: Nervenarzt Source Type: research

Associations between structure- and process-orientated measures and stroke long term mortality – an observational study based on routine data
This study analyzes these measures in combination, considering patients ’ comorbidities as well as stroke severity in a longitudinal perspective.
Source: Journal of Stroke and Cerebrovascular Diseases - July 27, 2023 Category: Neurology Authors: Dijana Ebbeler, Michael Schneider, Otto Busse, Klaus Berger, Patrik Dr öge, Christian Günster, Björn Misselwitz, Nina Timmesfeld, Max Geraedts Source Type: research

Coronavirus disease-19 (COVID-19) related acute stroke causing Transient Global Amnesia
Transient global amnesia (TGA) presents as an acute anterograde amnesia that generally resolves within 24 hrs.1 Werner et al. had noted increasing TGA since severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak in their hospital in Germany and reported 16 patients with TGA between February 1st and May 15th 2020 compared to their 10-year average of 9.72 In our series we noted 2 patients who presented with TGA secondary to acute hippocampal stroke in COVID-19 positive patients.
Source: Journal of Stroke and Cerebrovascular Diseases - March 5, 2021 Category: Neurology Authors: Ramnath Santosh Ramanathan, Ari Wachsman Source Type: research

Intravenous Thrombolysis in Posterior Circulation Stroke
Conclusions: Up to date, no data about PCIS and IVT are available from RTCs. Based on limited results from retrospective clinical studies and case series, IVT is safer for use in PCIS than in ACIS. Patients with brainstem ischemia, vertebral artery occlusion, and absence of basilar or posterior cerebral artery occlusion could be considered for treatment with IVT even in borderline cases. Time to IVT in PCIS seems to be a less crucial factor than in ACIS. IVT for PCIS may be beneficial even after 4.5 h from symptom onset. Introduction History of Intravenous Thrombolysis—The Most Relevant Studies Intravenous...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Clinical Improvement Following Stroke Promptly Reverses Post-stroke Cellular Immune Alterations
Conclusions: SIIA are detectable on admission of acute stroke patients. While it was assumed that post-stroke immunosuppression is rapidly reversed with improvement this is the first data set that shows that improvement actually is associated with a rapid reversal of SIIA demonstrating that SIIA require a constant signal to persist. The observation that HMGB-1 serum concentrations were similar in improved and non-improved cohorts argues against a role for this pro-inflammatory mediator in the maintenance of SIIA. Serum miRNA observed to be regulated in stroke in other publications was counter regulated with improvement in ...
Source: Frontiers in Neurology - April 30, 2019 Category: Neurology Source Type: research

Postreperfusion Blood Pressure Variability After Endovascular Thrombectomy Affects Outcomes in Acute Ischemic Stroke Patients With Poor Collateral Circulation
Conclusion: Postreperfusion BP management by decreasing BPV may have influence on improving clinical outcome in cases of poor collateral circulation among patients achieving successful recanalization after ERT. Introduction Endovascular recanalization therapy (ERT) has been adopted as standard stroke care in patients with acute ischemic stroke (1–6). Time to recanalization and degree of recanalization are the most important predictors of clinical outcomes after ERT (7). Before recanalization, an effort to reduce the time from symptom onset to reperfusion is critical for penumbral salvage. After recanalization...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

Corticospinal Tract Integrity and Long-Term Hand Function Prognosis in Patients With Stroke
Conclusions: The present study showed that CST integrity (at 6 months after onset) in patients with chronic stroke was related to functional hand status. In addition, the mid-pons FA value was more predictive of functional restoration of the hand than the FN or FA value at the pontomedullary junction. These results may be useful in predicting the functional restoration of the hand and understanding the functional prognosis of stroke. Introduction Restoration of hand function is one of the most important goals for patients with stroke (1). Thus, techniques that aid in predicting restoration of hand function are also i...
Source: Frontiers in Neurology - April 14, 2019 Category: Neurology Source Type: research

Frequency of Hemorrhage on Follow Up Imaging in Stroke Patients Treated With rt-PA Depending on Clinical Course
Conclusions: Frequency of hemorrhagic transformation in Routine follow-up brain imaging and consecutive changes in therapeutic management were different depending on clinical course measured by NHISS score. Introduction Brain imaging 24–36 h after systemic thrombolysis for acute ischemic stroke is recommended in American Stroke Association and European Stroke Organization guidelines (1, 2). Brain imaging is performed to detect secondary bleeding or hemorrhagic transformation in order to adapt medical stroke prevention if necessary. Guideline recommendations are based on the results of the first study on rt-PA...
Source: Frontiers in Neurology - April 15, 2019 Category: Neurology Source Type: research

Conveniently-Grasped Field Assessment Stroke Triage (CG-FAST): A Modified Scale to Detect Large Vessel Occlusion Stroke
Conclusions: CG-FAST scale could be an effective and simple scale for accurate identification of LVOS among AIS patients. Introduction Large vessel occlusion stroke (LVOS) often leads to severe disability and mortality. Although endovascular therapy (EVT) has been proved to be effective for LVOS patients (1–9), especially in anterior circulation, its benefit is highly time-dependent (10, 11). As hospitals with around-the-clock endovascular capability are scarce in many parts of the world and patients admitted directly to a CSC would have better outcomes than those receiving drip and ship treatment (12, 13), t...
Source: Frontiers in Neurology - April 16, 2019 Category: Neurology Source Type: research