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Association of serum markers of oxidative stress with myocardial infarction and stroke: pooled results from four large European cohort studies
AbstractOxidative stress contributes to endothelial dysfunction and is involved in the pathogenesis of myocardial infarction (MI) and stroke. However, associations of biomarkers of oxidative stress with MI and stroke have not yet been addressed in large cohort studies. A nested case –control design was applied in four population-based cohort studies from Germany, Czech Republic, Poland and Lithuania. Derivatives of reactive oxygen metabolites (d-ROMs) levels, as a proxy for the reactive oxygen species burden, and total thiol levels (TTL), as a proxy for the reductive capacity , were measured in baseline serum samples of ...
Source: European Journal of Epidemiology - November 7, 2018 Category: Epidemiology Source Type: research

Podcast: Electromechanical-assisted training for improving arm function and disability after stroke
A common consequence for people who have a stroke is a reduction in their arm function. Various approaches are available to try to help and, in September 2018, the Cochrane Review for one of these, electromechanical and robot ‐assisted arm training, was updated by a team of researchers from Germany. We asked lead author, Jan Mehrholz from Dresden Medical School, to tell us about the latest findings in this podcast." More than two ‐thirds of people who have had a stroke have difficulties with reduced arm function. This can limit their ability to perform everyday activities and electromechanical and robot‐assisted arm ...
Source: Cochrane News and Events - December 10, 2018 Category: Information Technology Authors: Lydia Parsonson Source Type: news

Peptidase neurolysin functions to preserve the brain after ischemic stroke in male mice
This study is the first to document functional significance of Nln in pathophysiology of stroke and provide evidence that Nln is an endogenous mechanism functioning to preserve the brain from ischemic injury.This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - September 4, 2019 Category: Neuroscience Authors: Srinidhi Jayaraman, Abdullah Al Shoyaib, Joanna Kocot, Heidi Villalba, Faisal F. Alamri, Mamoon Rashid, Naomi J. Wangler, Ekram A. Chowdhury, Nadezhda German, Thiruma V. Arumugam, Thomas J. Abbruscato, Vardan T. Karamyan Tags: Original Article Source Type: research

Quality of care of acute ischemic stroke in Germany 2018.
Abstract In this overview the current quality of acute in-hospital care of stroke patients in Germany in 2018 is described based on standardized and evidence-based quality indicators. For this purpose the reports of the regional quality assurance projects for stroke care, which collaborated within the German-speaking Stroke Registers Study Group (ADSR) were analyzed. Overall, more than 280,000 acute admissions of stroke patients were documented in the included quality assurance projects. The results regarding the defined 16 quality indicators comprising diagnostics, acute treatment, rehabilitation and secondary pr...
Source: Der Nervenarzt - April 29, 2020 Category: Neurology Authors: Misselwitz B, Grau A, Berger K, Bruder I, Burmeister C, Hermanek P, Hohnhold R, Koennecke HC, Matthis C, Heuschmann PU Tags: Nervenarzt Source Type: research

A review of mobile stroke units
AbstractPurpose of reviewMobile stroke units (MSUs) for prehospital treatment and management of patients with acute stroke have been developed more than a decade ago and is currently spreading worldwide. This review discusses the history of MSU and current operations and research.Recent findingsMultiple studies have shown that MSU can significantly reduce treatment time with a tenfold increase of patients treated within the first 60  min of symptom onset. Recent preliminary results from the Berlin Prehospital or Usual Delivery of Acute Stroke Care trial (B-PROUD) showed a positive shift in modified Rankin Scale (mRS) scor...
Source: Journal of Neurology - May 17, 2020 Category: Neurology Source Type: research

Modeling the Optimal Transportation for Acute Stroke Treatment
ConclusionOur study showed a  considerable impact of the diurnal variations in traffic rate and direction of travel on optimal stroke transportation. Stroke systems of care should take real time traffic information into account.
Source: Clinical Neuroradiology - July 15, 2020 Category: Neurology Source Type: research

Regional Deprivation, Stroke Incidence, and Stroke Care-An Analysis of Billing and Quality Assurance Data From the German State of Rhineland-Palatinate
CONCLUSION: These findings document a relationship between regional deprivation and the occurrence of acute ischemic stroke. Poorer GIMD 2010 scores were associated with worse care outcomes in a number of variables, but the absolute differences were small.PMID:33663687 | DOI:10.3238/arztebl.m2021.0149
Source: Deutsches Arzteblatt International - March 5, 2021 Category: General Medicine Authors: Armin J Grau Sieghard Dienlin Dirk Bartig Werner Maier Florian Buggle Heiko Becher Source Type: research

Regional Deprivation, Stroke Incidence, and Stroke Care —An Analysis of Billing and Quality Assurance Data From the German State of Rhineland-Palatinate
CONCLUSION: These findings document a relationship between regional deprivation and the occurrence of acute ischemic stroke. Poorer GIMD 2010 scores were associated with worse care outcomes in a number of variables, but the absolute differences were small.PMID:33663687 | DOI:10.3238/arztebl.m2021.0149
Source: Deutsches Arzteblatt International - March 5, 2021 Category: General Medicine Authors: Armin J Grau Sieghard Dienlin Dirk Bartig Werner Maier Florian Buggle Heiko Becher Source Type: research

Predicting the Risk of Ischemic Stroke in Patients Treated with Novel Oral Anticoagulants: A Machine Learning Approach
Conclusions: The stroke risk in AF patients treated with NOAC could be predicted based on comorbidities like ischemic heart diseases, urinary tract infections, and dementia additionally to age and male sex. Knowing and addressing these factors may help reduce the risk of stroke in this patient population.Neuroepidemiology
Source: Neuroepidemiology - July 21, 2021 Category: Epidemiology Source Type: research

Regional Deprivation, Stroke Incidence, and Stroke Care
CONCLUSION: These findings document a relationship between regional deprivation and the occurrence of acute ischemic stroke. Poorer GIMD 2010 scores were associated with worse care outcomes in a number of variables, but the absolute differences were small.PMID:34304754 | DOI:10.3238/arztebl.m2021.0149
Source: Deutsches Arzteblatt International - July 26, 2021 Category: General Medicine Authors: Armin J Grau Sieghard Dienlin Dirk Bartig Werner Maier Florian Buggle Heiko Becher Source Type: research

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