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Drug: Metformin
Countries: China Health
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Total 241 results found since Jan 2013.
Pharmacokinetic Variables of Dapagliflozin/Metformin Extended-Release Fixed-Dose Combination in Healthy Chinese Volunteers and Regional Comparison
This study evaluated the bioequivalence of the dapagliflozin/metformin FDC product versus IC administration in healthy volunteers from a Chinese population and assessed the safety profile of the FDC product. In addition, pharmacokinetic (PK) and safety comparisons of dapagliflozin and metformin across different regions were conducted to evaluate regional differences.METHODS: This single-center, open-label, parallel-cohort, randomized, 2-period, crossover study enrolled Chinese adults (aged 18-55 years). Volunteers in cohort 1 received either a single FDC tablet of dapagliflozin/metformin extended release (XR) (5/500 mg) or...
Source: Clinical Therapeutics - July 13, 2023 Category: Drugs & Pharmacology Authors: Xiaoying Zhao Rui Ning Andrew Hui David W Boulton Weifeng Tang Source Type: research
Metformin may be a viable adjunctive therapeutic option to potentially enhance immune reconstitution in HIV-positive immunological non-responders
Chin Med J (Engl). 2023 May 29. doi: 10.1097/CM9.0000000000002493. Online ahead of print.ABSTRACTIncomplete immune reconstitution remains a global challenge for human immunodeficiency virus (HIV) treatment in the present era of potent antiretroviral therapy (ART), especially for those individuals referred to as immunological non-responders (INRs), who exhibit dramatically low CD4+ T-cell counts despite the use of effective antiretroviral therapy, with long-term inhibition of viral replication. In this review, we provide a critical overview of the concept of ART-treated HIV-positive immunological non-response, and also expl...
Source: Chinese Medical Journal - May 29, 2023 Category: General Medicine Authors: Silvere D Zaongo Yaokai Chen Source Type: research
Interaction between OCT1 and LPIN1 polymorphisms and response to pioglitazone-metformin tablets in patients with polycystic ovary syndrome
Chin Med J (Engl). 2023 May 26. doi: 10.1097/CM9.0000000000002322. Online ahead of print.NO ABSTRACTPMID:37232475 | DOI:10.1097/CM9.0000000000002322
Source: Chinese Medical Journal - May 26, 2023 Category: General Medicine Authors: Haixia Zeng Yanting Huang Dengke Liu Tianqin Xie Zheng Chen Qiulan Huang Xiaojun Zhou Xiaoyang Lai Jianping Liu Source Type: research
Dihydromyricetin promotes GLP-1 release and glucose uptake by STC-1 cells and enhances the effects of metformin upon STC-1 cells and diabetic mouse model
CONCLUSION: Dihydromyricetin promotes GLP-1 release and glucose uptake by STC-1 cells and enhances the effects of metformin upon STC-1 cells and diabetic mice, which might ameliorate diabetes through improving L cell functions. The Erk1/2 and AMPK signaling pathways might be involved.PMID:37229936 | DOI:10.1016/j.tice.2023.102108
Source: Tissue and Cell - May 25, 2023 Category: Cytology Authors: Yuanzhi Yao Xiaoying Li Xiaoqin Yang Hai Mou Lin Wei Source Type: research
Unusual phenomenon-"polyp" arising from a diverticulum: A case report
CONCLUSION: Granulation tissue associated with healed diverticular perforations resemble polyps. Tattooing around these sites may allow for future targeted colonic resections.PMID:37215427 | PMC:PMC10198085 | DOI:10.12998/wjcc.v11.i13.3070
Source: Clinical Colorectal Cancer - May 22, 2023 Category: Cancer & Oncology Authors: Jacqueline Jin Li Liew Wei Shyann Lim Frederick H Koh Source Type: research
Efficacy of Exenatide Administered Twice Daily in Body Mass Index Reduction in Patients with Type 2 Diabetes Mellitus
CONCLUSION: BMI scores improved after exenatide treatment for 52 weeks in T2DM patients. Weight loss was affected by baseline body weight and blood glucose level. In addition, BMI reduction from the baseline to 52 weeks was positively correlated with baseline HbA1c, hsCRP, and SBP. Trial Registration. Chinese Clinical Trial Registry (ChiCTR-1800015658).PMID:37214201 | PMC:PMC10199797 | DOI:10.1155/2022/7128859
Source: Atherosclerosis - May 22, 2023 Category: Cardiology Authors: Jie Zhang Tong-Zhang Xian Yu Teng Xiuzhi Wang Ming-Xiao Wu Chen Li Weihao Wang Fuli Man Xianbo Zhang Xiaoxia Wang Li-Xin Guo Source Type: research
Fight Aging! Newsletter, May 22nd 2023
Conclusions to be Drawn
A High Fat Diet Accelerates Atherosclerosis Less Directly than One Might Suspect
How to Construct Measures of Biological Age
A Long-Term Comparison of Metformin in Diabetics with Non-Diabetic Controls
In Search of Distinctive Features of the Gut Microbiome in Long-Lived Individuals
Greater Fitness in Humans Implies a Younger Epigenome and Transcriptome
Intestinal Barrier Dysfunction as a Feature of Aging in Many Species
NAFLD as an Age-Related Condition
Towards Sensory Hair Cell Regeneration in the Inner Ear
Raised Levels of PLG...
Source: Fight Aging! - May 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
MET Inhibits the Proliferation of EC Cells by Increasing MPA Sensitivity
CONCLUSIONS: MET inhibited the proliferation of EC cells by increasing MPA-sensitivity, which was dependent on the inhibition of the CD133 expression and the Akt/mTOR pathway. In addition, if MET acts as an effective progestin sensitizer, it certainly offers promising therapeutic prospects for patients with early-stage EC or overgrown endometrium who have fertility requirements.PMID:37171945
Source: Alternative Therapies in Health and Medicine - May 12, 2023 Category: Complementary Medicine Authors: Fang Sun Jiayun Zhou Yongxin Hao Lei Kuang Bei Zhang Source Type: research
