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Emerging Therapies for Glioblastoma
Conclusions and RelevanceGlioblastoma is an aggressive tumor with heterogeneous molecular features and complex host interactions, many of which are amenable to therapeutic intervention. Meaningful treatment advances will depend on identifying agents that target mechanistic vulnerabilities that are relevant to specific subgroups of patients; increasing patient enrollment into clinical trials is essential to accelerate the development of patient-tailored treatments.
Source: JAMA Neurology - November 1, 2014 Category: Neurology Source Type: research

Concepts for Immunotherapies in Gliomas
Semin Neurol 2018; 38: 062-072 DOI: 10.1055/s-0037-1620274Strategies to empower the immune system to successfully attack cancers, including vaccination approaches, adaptive T cell therapies, and immune checkpoint modulators, have recently achieved remarkable success across a spectrum of cancer indications. Nonetheless, with rare exception, only a minority of patients with a given type of cancer respond to an immunotherapeutic when administered as single-agent therapy. Although under extensive laboratory and clinical investigation, the role of these approaches for glioma patients remains to be determined. While the central ...
Source: Seminars in Neurology - March 16, 2018 Category: Neurology Authors: Platten, Michael Reardon, David A. Tags: Review Article Source Type: research

Zika Virus Potentiates the Development of Neurological Defects and Microcephaly: Challenges and Control Strategies
Conclusions Apart West Nile virus (78), thousands of congenital microcephaly cases, fetal brain tissue damage and neurological syndromes have been associated with ZIKV infection. Unfortunately, the epidemics of this mosquito born, and a relative stable virus is on a rise. Although congenital microcephaly is a rare disorder however, due to lack of standardized diagnostic test facilities, the incidence in the geographically widespread ZIKV epidemic regions is higher. Animals studies showed that ZIKV is a neurotropic virus. It directly targets the developing embryonic brain cells by inducing apoptosis, cell-cycle arrest, and...
Source: Frontiers in Neurology - April 8, 2019 Category: Neurology Source Type: research

Treatment Challenges in Multiple Sclerosis – A Continued Role for Glatiramer Acetate?
We describe here several populations in which GA may represent a useful treatment option to overcome challenges due to advanced age or comorbidities (e.g., hepatic or renal disease, cancer). Further, we weigh GA's potential merits in other settings where PwMS and their neurologists must base treatment decisions on factors other than selecting the most effective DMT, e.g., family planning, conception and pregnancy, or the need for vaccination.
Source: Frontiers in Neurology - April 15, 2022 Category: Neurology Source Type: research

Type I interferon mediated induction of somatostatin leads to suppression of ghrelin and appetite thereby promoting viral immunity in mice
Brain Behav Immun. 2021 Apr 22:S0889-1591(21)00176-8. doi: 10.1016/j.bbi.2021.04.018. Online ahead of print.ABSTRACTLoss of appetite (anorexia) is a typical behavioral response to infectious diseases that often reduces body weight. Also, anorexia can be observed in cancer and trauma patients, causing poor quality of life and reduced prospects of positive therapeutic outcomes. Although anorexia is an acute symptom, its initiation and endocrine regulation during antiviral immune responses are poorly understood. During viral infections, plasmacytoid dendritic cells (pDCs) produce abundant type I interferon (IFN-I) to initiate...
Source: Brain, Behavior, and Immunity - April 25, 2021 Category: Neurology Authors: Susanne Stutte Janina Ruf Ina Kugler Hellen Ishikawa-Ankerhold Andreas Parzefall Peggy Marconi Takahiro Maeda Tsuneyasu Kaisho Anne Krug Bastian Popper Henning Lauterbach Marco Colonna Ulrich von Andrian Thomas Brocker Source Type: research

Breast Cancer Survivors' Typhoid Vaccine Responses: Chemotherapy, Obesity, and Fitness Make a Difference
CONCLUSIONS: This study provided novel data on chemotherapy's longer-term adverse immune consequences. The data also have an important public health message: even relatively low levels of fitness can benefit the innate immune response to a vaccine.PMID:35378230 | DOI:10.1016/j.bbi.2022.03.019
Source: Brain, Behavior, and Immunity - April 4, 2022 Category: Neurology Authors: Janice K Kiecolt-Glaser Megan Renna Juan Peng John Sheridan Maryam Lustberg Bhuvaneswari Ramaswamy Robert Wesolowski Jeffrey B VanDeusen Nicole O Williams Sagar D Sardesai Anne M Noonan Raquel E Reinbolt Daniel G Stover Mathew A Cherian William B Malarkey Source Type: research

Breast cancer survivors' typhoid vaccine responses: Chemotherapy, obesity, and fitness make a difference
CONCLUSIONS: This study provided novel data on chemotherapy's longer-term adverse immune consequences. The data also have an important public health message: even relatively low levels of fitness can benefit the innate immune response to a vaccine.PMID:35378230 | DOI:10.1016/j.bbi.2022.03.019
Source: Brain, Behavior, and Immunity - April 4, 2022 Category: Neurology Authors: Janice K Kiecolt-Glaser Megan Renna Juan Peng John Sheridan Maryam Lustberg Bhuvaneswari Ramaswamy Robert Wesolowski Jeffrey B VanDeusen Nicole O Williams Sagar D Sardesai Anne M Noonan Raquel E Reinbolt Daniel G Stover Mathew A Cherian William B Malarkey Source Type: research

Immunosenescence and multiple sclerosis
Neurol Neurochir Pol. 2022 Jun 23. doi: 10.5603/PJNNS.a2022.0045. Online ahead of print.ABSTRACTChanges in the immune system associated with ageing are known as immunosenescence. This is characterised by a decline in immune response, chronic inflammation and an increased risk of autoimmune diseases. A chronic inflammatory process with persistent production of proinflammatory mediators increases the risk for morbidity and mortality related to age, and has been dubbed 'inflamm-ageing'. Immunosenescence is associated with a decrease in the number of naive T and B cells, NK cells and disruption of the pro- and anti-inflammator...
Source: Neurologia i Neurochirurgia Polska - June 23, 2022 Category: Neurology Authors: Monika Adamczyk-Sowa Maria Nowak-Kiczmer Jerzy Jaroszewicz Thomas Berger Source Type: research

Typhoid Vaccine Does Not Impact Feelings of Social Connection or Social Behavior in a Randomized Crossover Trial Among Middle-Aged Female Breast Cancer Survivors
CONCLUSION: Milder inflammatory stimuli may not affect social processes. Higher levels of inflammation or, relatedly, more sickness symptoms may be necessary to recapitulate prior findings of social avoidance.PMID:36208853 | DOI:10.1016/j.bbi.2022.09.021
Source: Brain, Behavior, and Immunity - October 8, 2022 Category: Neurology Authors: Annelise A Madison Baldwin Way Kyle Ratner Megan Renna Rebecca Andridge Juan Peng M Rosie Shrout John Sheridan Maryam Lustberg Bhuvaneswari Ramaswamy Robert Wesolowski Jeffrey B VanDeusen Nicole O Williams Sagar D Sardesai Anne M Noonan Raquel E Reinbolt Source Type: research

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