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Identification of the Transcription Factor ATF3 as a Direct and Indirect Regulator of the LDLR
This study relied on two main resources: (1) genes with impact on atherosclerosis/CAD, and (2) liver-specific transcriptome analyses from human and mouse studies. The transcription factor activating transcription factor 3 (ATF3) was identified as a key regulator of a liver network relevant to atherosclerosis and linked to inflammation and cholesterol metabolism. ATF3 was predicted to be a direct and indirect (via MAF BZIP Transcription Factor F (MAFF)) regulator of low-density lipoprotein receptor (LDLR). Chromatin immunoprecipitation DNA sequencing (ChIP-seq) data from human liver cells revealed an ATF3 binding motif in t...
Source: Atherosclerosis - September 23, 2022 Category: Cardiology Authors: Sabine Bauer Jana Eigenmann Yuqi Zhao Julia Fleig Johann S Hawe Calvin Pan Dario Bongiovanni Simon Wengert Angela Ma Aldons J Lusis Jason C Kovacic Johan L M Bj örkegren Lars Maegdefessel Heribert Schunkert Moritz von Scheidt Source Type: research

lncRNA ZEB1-AS1 Mediates Oxidative Low-Density Lipoprotein-Mediated Endothelial Cells Injury by Post-transcriptional Stabilization of NOD2
Conclusion We report the discovery that ZEB1-AS1 functionally participates in ox-LDL-induced ECs injury via LRPPRC-mediated stabilization of NOD2. Uncovering the precise role of ZEB1-AS1/LRPPRC/NOD2 pathway in the progression of ox-LDL-induced ECs death and AS will not only increase our knowledge of ox-LDL-induced AS, but also enable the development of novel therapeutic strategies to overcome oxidation product-induced diseases. Author Contributions XX and CL designed and mainly did the study. CM, ZD, and YD helped and did the study. Conflict of Interest Statement The authors declare that the research was conducted in ...
Source: Frontiers in Pharmacology - April 15, 2019 Category: Drugs & Pharmacology Source Type: research

Rab27a Regulates Human Perivascular Adipose Progenitor Cell Differentiation
ConclusionsPVAT-APC from CABG donors express common adipocyte progenitor markers and differentiate into UCP1-containing adipocytes. Rab27a has an endogenous role in promoting the maturation of adipocytes from human PVAT-derived APC.
Source: Cardiovascular Drugs and Therapy - August 13, 2018 Category: Cardiology Source Type: research

Long Non-coding RNA-mRNA Correlation Analysis Reveals the Potential Role of HOTAIR in Pathogenesis of Sporadic Thoracic Aortic Aneurysm.
CONCLUSION: Transcriptomic and lncRNA-mRNA correlation analysis revealed HOTAIR was downregulated in STAA and associated with genes involved in extracellular matrix remodelling. In vitro experiments confirmed that knockdown of HOTAIR could induce apoptosis and suppress collagen types I and III expression in human aortic smooth muscle cells. PMID: 28757056 [PubMed - as supplied by publisher]
Source: PubMed: Eur J Vasc Endovasc ... - July 27, 2017 Category: Surgery Authors: Guo X, Chang Q, Pei H, Sun X, Qian X, Tian C, Lin H Tags: Eur J Vasc Endovasc Surg Source Type: research

Dilong Prevents the High- KCl Cardioplegic Solution Administration-Induced Apoptosis in H9c2 Cardiomyoblast Cells Mediated by MEK.
In this study, we applied Dilong extract to reduce myocardial cell damage from High-KCS infusion and further investigated the mechanisms. H9c2 cardiomyoblast cells were cultured in serum-free medium for 4 h and then treated with Dilong at 31.25, 62.5, 125, and 250 mg/mL for 24 h, which was then followed by High-KCS treatment for 3 h to detect the protective mechanisms of Dilong behind cardiomyocyte apoptosis and cardiac fibrosis. Cells were harvested for MTT assay, TUNEL assay, and western blot analysis. We found that High-KCS-induced cardiomyocyte apoptosis, enhanced the protein level of pro-apoptotic Bad, released cytoch...
Source: The American Journal of Chinese Medicine - December 7, 2014 Category: Complementary Medicine Authors: Han CK, Kuo WW, Shen CY, Chen TS, Pai P, Tsai CH, Lo FY, Ju DT, Huang CY Tags: Am J Chin Med Source Type: research