lncRNA ZEB1-AS1 Mediates Oxidative Low-Density Lipoprotein-Mediated Endothelial Cells Injury by Post-transcriptional Stabilization of NOD2

Conclusion We report the discovery that ZEB1-AS1 functionally participates in ox-LDL-induced ECs injury via LRPPRC-mediated stabilization of NOD2. Uncovering the precise role of ZEB1-AS1/LRPPRC/NOD2 pathway in the progression of ox-LDL-induced ECs death and AS will not only increase our knowledge of ox-LDL-induced AS, but also enable the development of novel therapeutic strategies to overcome oxidation product-induced diseases. Author Contributions XX and CL designed and mainly did the study. CM, ZD, and YD helped and did the study. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Footnotes ^ http://rna.tbi.univie.ac.at/ References Abou-Jaoude, A., Badique, L., Mlih, M., Awan, S., Guo, S., Lemle, A., et al. (2018). Loss of the adaptor protein shca in endothelial cells protects against monocyte macrophage adhesion, LDL-oxydation, and atherosclerotic lesion formation. Sci. Rep. 8:4501. doi: 10.1038/s41598-018-22819-3 PubMed Abstract | CrossRef Full Text | Google Scholar Blann, A. D. (1999). Endothelial cell damage and the development or progression of atherosclerosis. Clin. Sci. 97, 119–121. doi: 10.1042/cs0970119 CrossRef Full Text | Google Scholar Caruso, R., Warner, N., Inohara, N., and Nunez, G. (2014). NOD1 and NOD2: signaling, host defense, and inflammatory disease. Immunity 41, 898...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research