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Specialty: Nanotechnology
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Total 382 results found since Jan 2013.
ASAP Intercalation-Driven Formation of siRNA Nanogels for Cancer Therapy
Nano LettersDOI: 10.1021/acs.nanolett.1c03539
Source: Nano Letters - November 1, 2021 Category: Nanotechnology Authors: Xiangang Huang, Gongwei Wu, Chuang Liu, Xianwu Hua, Zhongmin Tang, Yufen Xiao, Wei Chen, Jun Zhou, Na Kong, Peng Huang, Jinjun Shi, and Wei Tao Source Type: research
A polydopamine nanomedicine used in photothermal therapy for liver cancer knocks down the anti-cancer target NEDD8-E3 ligase ROC1 (RBX1)
Knocking down the oncogene ROC1 with siRNA inhibits the proliferation of cancer cells by suppressing the Neddylation pathway. However, methods for delivering siRNA in vivo to induce this high anticancer activi...
Source: Journal of Nanobiotechnology - October 15, 2021 Category: Nanotechnology Authors: Zhanxia Zhang, Junqian Zhang, Jianhui Tian and Hegen Li Tags: Research Source Type: research
DNA Origami Frameworks Enabled Self ‐Protective siRNA Delivery for Dual Enhancement of Chemo‐Photothermal Combination Therapy
Octahedral DNA origami frameworks (OctDOFs) are constructed for sterically enveloping and efficiently delivering siRNAs for chemo-photothermal combination cancer therapy. The confined space created by this nanoscaffold is able to shield the inward anchored siRNAs from degradative RNases during blood circulation, thus achieved dual sensitization of cancer cells to chemodrugs and hyperthermia. AbstractAlthough chemotherapy and photothermal therapy are widely used to combat cancer, their efficacy is often limited by multidrug resistance. Small interfering RNAs (siRNAs) have ability to suppress the expression of target genes, ...
Source: Small - October 6, 2021 Category: Nanotechnology Authors: Tingting Xu,
Sha Yu,
Yao Sun,
Shaojun Wu,
Di Gao,
Mingyang Wang,
Zhenzhen Wang,
Ye Tian,
Qianhao Min,
Jun ‐Jie Zhu Tags: Research Article Source Type: research
Endogenous microRNA triggered enzyme-free DNA logic self-assembly for amplified bioimaging and enhanced gene therapy via in situ generation of siRNAs
Small interfering RNA (siRNA) has emerged as a kind of promising therapeutic agents for cancer therapy. However, the off-target effect and degradation are the main challenges for siRNAs delivery. Herein, an en...
Source: Journal of Nanobiotechnology - September 26, 2021 Category: Nanotechnology Authors: Qinghua Jiang, Shuzhen Yue, Kaixin Yu, Tian Tian, Jian Zhang, Huijun Chu, Zhumei Cui and Sai Bi Tags: Research Source Type: research
ASAP A siRNA-Assisted Assembly Strategy to Simultaneously Suppress “Self” and Upregulate “Eat-Me” Signals for Nanoenabled Chemo-Immunotherapy
ACS NanoDOI: 10.1021/acsnano.1c04458
Source: ACS Nano - September 20, 2021 Category: Nanotechnology Authors: Yuxi Zhang, Zhenghai Zhang, Senlin Li, Liang Zhao, Dongdong Li, Ziyang Cao, Xiaoding Xu, and Xianzhu Yang Source Type: research
ASAP Top-Down Fabricated microPlates for Prolonged, Intra-articular Matrix Metalloproteinase 13 siRNA Nanocarrier Delivery to Reduce Post-traumatic Osteoarthritis
ACS NanoDOI: 10.1021/acsnano.1c04005
Source: ACS Nano - August 19, 2021 Category: Nanotechnology Authors: Sean K Bedingfield, Juan M. Colazo, Martina Di Francesco, Fang Yu, Danielle D. Liu, Valentina Di Francesco, Lauren E. Himmel, Mukesh K. Gupta, Hongsik Cho, Karen A. Hasty, Paolo Decuzzi, and Craig L. Duvall Source Type: research
Modular Lipid Nanoparticle Platform Technology for siRNA and Lipophilic Prodrug Delivery
Lipid nanoparticles (LNPs) are the most advanced nanocarriers for nucleic acid therapeutics such as small interfering RNA (siRNA). Here, it is showcased how LNP technology's modularity and the ability to stably incorporate lipophilic small molecule prodrugs provide ample opportunities to develop combination therapies by co-encapsulating multiple therapeutic agents in a single formulation. AbstractSuccessfully employing small interfering RNA (siRNA) therapeutics requires the use of nanotechnology for efficient intracellular delivery. Lipid nanoparticles (LNPs) have enabled the approval of various nucleic acid therapeutics. ...
Source: Small - August 2, 2021 Category: Nanotechnology Authors: Roy Meel,
Sam Chen,
Josh Zaifman,
Jayesh A. Kulkarni,
Xu Ran S. Zhang,
Ying K. Tam,
Marcel B. Bally,
Raymond M. Schiffelers,
Marco A. Ciufolini,
Pieter R. Cullis,
Yuen Yi C. Tam Tags: Research Article Source Type: research
ASAP Scalable mRNA and siRNA Lipid Nanoparticle Production Using a Parallelized Microfluidic Device
Nano LettersDOI: 10.1021/acs.nanolett.1c01353
Source: Nano Letters - June 30, 2021 Category: Nanotechnology Authors: Sarah J. Shepherd, Claude C. Warzecha, Sagar Yadavali, Rakan El-Mayta, Mohamad-Gabriel Alameh, Lili Wang, Drew Weissman, James M. Wilson, David Issadore, and Michael J. Mitchell Source Type: research
ASAP Gold-Nanocluster-Mediated Delivery of siRNA to Intact Plant Cells for Efficient Gene Knockdown
Nano LettersDOI: 10.1021/acs.nanolett.1c01792
Source: Nano Letters - June 21, 2021 Category: Nanotechnology Authors: Huan Zhang ▽, Yuhong Cao▽△, Dawei Xu, Natalie S. Goh, Gozde S. Demirer, Stefano Cestellos-Blanco, Yuan Chen, Markita P. Landry, and Peidong Yang Source Type: research
Delivery of siHIF ‐1α to Reconstruct Tumor Normoxic Microenvironment for Effective Chemotherapeutic and Photodynamic Anticancer Treatments
An integrated amphiphilic delivery system (RSCD) based on Angiotensin II receptor blocker candesartan for siRNA against the hypoxia-inducible factor-1 alpha (HIF-1 α) is fabricated, aiming at both vascular and cellular “relaxation” to reconstruct a tumor normoxic microenvironment, which significantly improves the chemotherapeutic and photodynamic anticancer treatment. AbstractThe tumor hypoxic microenvironment not only induces genetic and epigenetic changes in tumor cells, immature vessels formation for oxygen demand, but also compromises the efficiency of therapeutic interventions. On the other hand, conventional the...
Source: Small - May 25, 2021 Category: Nanotechnology Authors: Xiaobing Chen,
Rongrong Jin,
Qian Jiang,
Qunjie Bi,
Ting He,
Xu Song,
Matthias Barz,
Hua Ai,
Xintao Shuai,
Yu Nie Tags: Research Article Source Type: research
Therapeutic Gene Silencing Using Targeted Lipid Nanoparticles in Metastatic Ovarian Cancer
Lipid nanoparticles encapsulating small interfering ribonucleic acids are developed that block two essential pathways for cancer cell survival. Targeting of metastasized ovarian cancer cells is further enhanced by coating nanoparticles with hyaluronan. Robust gene silencing in key tissues involved in ovarian cancer pathophysiology in an advanced ovarian cancer mouse model is demonstrated and improved median and overall survival observed. AbstractOvarian cancer is an aggressive tumor owing to its ability to metastasize from stage II onward. Herein, lipid nanoparticles (LNPs) that encapsulate combination of small interfering...
Source: Small - May 12, 2021 Category: Nanotechnology Authors: Manu Smriti Singh,
Srinivas Ramishetti,
Dalit Landesman ‐Milo,
Meir Goldsmith,
Sushmita Chatterjee,
Ramesh Palakuri,
Dan Peer Tags: Research Article Source Type: research
Sustained delivery of MMP-9 siRNA via thermosensitive hydrogel accelerates diabetic wound healing
Excessive expression of matrix metalloproteinase 9 (MMP-9) impedes healing of diabetic chronic wounds, thus wound dressing that could effectively inhibit the expression of MMP-9 offers significant clinical tra...
Source: Journal of Nanobiotechnology - May 5, 2021 Category: Nanotechnology Authors: Biyun Lan, Liming Zhang, Liqun Yang, Junfeng Wu, Na Li, Chenglin Pan, Xiaoyi Wang, Lexiang Zeng, Li Yan, Chuan Yang and Meng Ren Tags: Research Source Type: research
Tyrosine-modified linear PEIs for highly efficacious and biocompatible siRNA delivery in vitro and in vivo
Publication date: Available online 29 April 2021Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Michael Karimov, Marion Schulz, Tim Kahl, Sandra Noske, Malgorzata Kubczak, Ines Gockel, René Thieme, Thomas Büch, Anja Reinert, Maksim Ionov, Maria Bryszewska, Heike Franke, Ute Krügel, Alexander Ewe, Achim Aigner
Source: Nanomedicine: Nanotechnology, Biology and Medicine - April 29, 2021 Category: Nanotechnology Source Type: research
ASAP Caveolae-Mediated Endocytosis Drives Robust siRNA Delivery of Polymeric Nanoparticles to Macrophages
ACS NanoDOI: 10.1021/acsnano.0c08596
Source: ACS Nano - April 29, 2021 Category: Nanotechnology Authors: Yudong Song, Yanhua Wu, Lu Xu, Ting Jiang, Cui Tang, and Chunhua Yin Source Type: research
Interferon Regulatory Factor 5 siRNA-Loaded Folate-Modified Cationic Liposomes for Acute Lung Injury Therapy
Source: Journal of Biomedical Nanotechnology - April 21, 2021 Category: Nanotechnology Authors: Xu, Qin Guo, Mengran Jin, Xiaodong Jin, Quansheng He, Zhongshan Xiao, Wen Zou, Wei Xu, Ruiling Cheng, Lizhi He, Siyan Cao, Lili Elbahnasawy, Mostafa A. Peng, Wentao Jiang, Chunling Song, Xiangrong Tags: Articles Source Type: research
