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Specialty: Drugs & Pharmacology
Therapy: Stem Cell Therapy

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Total 69 results found since Jan 2013.

AKT2 siRNA delivery with amphiphilic-based polymeric micelles show efficacy against cancer stem cells.
Authors: Rafael D, Gener P, Andrade F, Seras-Franzoso J, Montero S, Fernández Y, Hidalgo M, Arango D, Sayós J, Florindo HF, Abasolo I, Schwartz S, Videira M Abstract Development of RNA interference-based therapies with appropriate therapeutic window remains a challenge for advanced cancers. Because cancer stem cells (CSC) are responsible of sustaining the metastatic spread of the disease to distal organs and the progressive gain of resistance of advanced cancers, new anticancer therapies should be validated specifically for this subpopulation of cells. A new amphihilic-based gene delivery system that combines Plu...
Source: Drug Delivery - April 20, 2018 Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research

Suppressing autophagy enhances disulfiram/copper-induced apoptosis in non-small cell lung cancer.
Abstract Autophagy, a cellular survival mechanism, is thought to allow the recycling of cellular breakdown products when cancer cells are subjected to chemotherapy, thus decreasing drug-induced apoptosis. Disulfiram (DSF), a drug widely used to control alcoholism, possesses anticancer activity by inducing apoptosis in vitro and in vivo in a copper (Cu)-dependent manner. Our previous studies proved that DSF/Cu exerts increased anti-tumor effects on non-small cell lung cancer (NSCLC) xenograft models, and inhibits NSCLC recurrence driven by ALDH-positive cancer stem cells. The present study is designed to investigat...
Source: European Journal of Pharmacology - March 13, 2018 Category: Drugs & Pharmacology Authors: Wu X, Xue X, Wang L, Wang W, Han J, Sun X, Zhang H, Liu Y, Che X, Yang J, Wu C Tags: Eur J Pharmacol Source Type: research

TMEM88 mediates inflammatory cytokines secretion by regulating JNK/P38 and canonical Wnt/ β-catenin signaling pathway in LX-2 cells
In conclusion, these results indicated that TMEM88 plays a significant role in TNF-α-enhanced cytokine (IL-6 and IL-1β) secretion of LX-2 cells via regulating JNK/P38 and canonical Wnt/β-catenin signaling pathway.
Source: Inflammopharmacology - November 20, 2017 Category: Drugs & Pharmacology Source Type: research

Biscarbamate Cross-Linked Low-Molecular-Weight Polyethylenimine for Delivering Anti-chordin siRNA into Human Mesenchymal Stem Cells for Improving Bone Regeneration
Chuandong Wang, Weien Yuan, Fei Xiao, Yaokai Gan, Xiaotian Zhao, Zhanjing Zhai, Xiaoying Zhao, Chen Zhao, Penglei Cui, Tuo Jin, Xiaodong Chen, Xiaoling Zhang
Source: Frontiers in Pharmacology - August 28, 2017 Category: Drugs & Pharmacology Source Type: research

TRPV4 functions in flow shear stress induced early osteogenic differentiation of human bone marrow mesenchymal stem cells.
In this study, using FSS and calcium imaging, we demonstrated that FSS activated early osteogenic differentiation, as shown by the early osteogenic differentiation marker osterix (Osx) and alkaline phosphatase (ALP) staining. Increases in intracellular Ca(2+) and in the percentage of responding cells were induced by FSS. However, the late osteogenic differentiation marker Ocn and in vitro mineralization were unchanged after FSS stimulation. TRPV4 channels mediated the FSS-induced Ca(2+) influx and osteogenic differentiation of MSCs, which were inhibited by a selective TRPV4 blocker HC-067047 and specific Trpv4 siRNA. Ca(2+...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 11, 2017 Category: Drugs & Pharmacology Authors: Hu K, Sun H, Gui B, Sui C Tags: Biomed Pharmacother Source Type: research

Icariin promotes proliferation and osteogenic differentiation of rat adipose-derived stem cells by activating the RhoA-TAZ signaling pathway
Publication date: April 2017 Source:Biomedicine & Pharmacotherapy, Volume 88 Author(s): Yaping Ye, Xingzhi Jing, Na Li, Yingxing Wu, Bingbing Li, Tao Xu Icariin, the main active flavonoid glucoside isolated from Herba epimedii, has been demonstrated to be a potential alternative therapy to prevent postmenopausal osteoporosis. Icariin has also been shown to regulate the proliferation and osteogenic differentiation of rat bone marrow stromal cells (rBMSCs). However, the detailed molecular mechanism of icariin has remained largely unknown. Besides, no investigation has focused on the relevance of icariin in the regul...
Source: Biomedicine and Pharmacotherapy - January 21, 2017 Category: Drugs & Pharmacology Source Type: research

Icariin promotes proliferation and osteogenic differentiation of rat adipose-derived stem cells by activating the RhoA-TAZ signaling pathway.
Abstract Icariin, the main active flavonoid glucoside isolated from Herba epimedii, has been demonstrated to be a potential alternative therapy to prevent postmenopausal osteoporosis. Icariin has also been shown to regulate the proliferation and osteogenic differentiation of rat bone marrow stromal cells (rBMSCs). However, the detailed molecular mechanism of icariin has remained largely unknown. Besides, no investigation has focused on the relevance of icariin in the regulation of rat adipose-derived stem cells (rASCs) proliferation and osteogenic differentiation. In the present study, we detected that icariin pro...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 21, 2017 Category: Drugs & Pharmacology Authors: Ye Y, Jing X, Li N, Wu Y, Li B, Xu T Tags: Biomed Pharmacother Source Type: research

Inhibition of long non-coding RNA IGF2AS protects apoptosis and neuronal loss in anesthetic-damaged mouse neural stem cell derived neurons.
CONCLUSIONS: Inhibiting endogenous IGF2AS can protect anesthetic-induced neurotoxicity in neural stem cells, possibly through complimentary IGF2 upregulation and its associated downstream signaling pathways. PMID: 27914827 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 29, 2016 Category: Drugs & Pharmacology Authors: Song C, Song C, Chen K, Zhang X Tags: Biomed Pharmacother Source Type: research

Dihydromyricetin enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells in vitro partially via the activation of Wnt / β‐catenin signaling pathway
This article is protected by copyright. All rights reserved.
Source: Fundamental and Clinical Pharmacology - July 29, 2016 Category: Drugs & Pharmacology Authors: Wei Zhang, Shengdong Wang, Houfa Yin, Erman Chen, Deting Xue, Qiang Zheng, Xiang Gao, Zhijun Pan Tags: Original Article Source Type: research

Plumbagin, a naphthaquinone derivative induces apoptosis in BRCA 1/2 defective castrate resistant prostate cancer cells as well as prostate cancer stem-like cells
In this study, we have analyzed the effect of Plumbagin (PB) and structurally related naphthaquinones on BRCA1/2 silenced prostate cancer cells and the ability of PB to target stem cells. Our cell proliferation studies showed that both PC-3 and DU145 cells were more sensitive to PB, though all the compounds induced mitochondrial potential loss, DNA fragmentation and morphological changes which are indicative of apoptosis. Both BRCA1/2 siRNA transfected PC-3 and DU145 cells exhibited increased sensitivity to PB. Gene expression profiling post PB treatment in BRCA1/2 silenced cells revealed that PB has a putative role in tum...
Source: Pharmacological Research - January 31, 2016 Category: Drugs & Pharmacology Source Type: research

Characterization and comparison of two novel nanosystems associated with siRNA for cellular therapy
In this study we developed and characterized two different siRNA NP. On one hand, sorbitan monooleate (Span®80) based NP incorporating the cationic components poly-l-arginine or cationized pullulan, thus allowing the association of siRNA were designed. These NP presented a small size (205nm) and a negative surface charge (−38mV). On the other hand, lipid nanocapsules (LNC) associating polymers with lipids and allowing encapsulation of siRNA complexed with lipoplexes were also developed. Their size was of 82nm with a positive surface charge of +7mV. Both NP could be frozen with appropriate cryoprotectors. Cytotoxicity an...
Source: International Journal of Pharmaceutics - December 13, 2015 Category: Drugs & Pharmacology Source Type: research

Estrogen receptor mediates simvastatin-stimulated osteogenic effects in bone marrow mesenchymal stem cells.
In this study, we hypothesize that the estrogen receptor (ER) mediates simvastatin-induced osteogenic differentiation. ER antagonists and siRNA were used to determine the involvement of the ER in simvastatin-induced osteogenesis in mouse bone marrow mesenchymal stem cells (D1 cells). Osteogenesis was evaluated by mRNA expression, protein level/activity of osteogenic markers, and mineralization. The estrogen response element (ERE) promoter activity and the ER-simvastatin binding affinity were examined. Our results showed that the simvastatin-induced osteogenic effects were decreased by treatment with ERα antagonists and ER...
Source: Biochemical Pharmacology - September 24, 2015 Category: Drugs & Pharmacology Authors: Chuang SC, Chen CH, Fu YC, Tai IC, Li CJ, Chang LF, Ho ML, Chang JK Tags: Biochem Pharmacol Source Type: research

Single-walled carbon nanotubes functionalized with aptamer and piperazine–polyethylenimine derivative for targeted siRNA delivery into breast cancer cells
In this study, we used a RNA aptamer against EpCAM (EpDT3) attached physically to our newly synthesized non-viral vector, based on single-walled carbon nanotube (SWNT) conjugated to piperazine–polyethylenimine derivative. The DNA transfection efficiency and siRNA delivery activity of the synthesized vector was investigated against upregulated BCL9l, which has been associated with breast and colorectal cancers. The complexes of the vector–aptamer/siRNA could specifically induce apoptosis by more than 20% in MCF-7 cell line as a positive EpCAM than MDA-MB-231 cells which are EpCAM negative. The decrease of BCL9l protein ...
Source: International Journal of Pharmaceutics - March 11, 2015 Category: Drugs & Pharmacology Source Type: research

Sonic hedgehog increases the skin wound‐healing ability of mouse embryonic stem cells through the microRNA 200 family
Conclusions and ImplicationsMouse ESCs accelerated skin wound healing by shh through down‐regulating E‐cadherin, an effect dependent on mmu‐miR‐141 and ‐200b. Our data provides evidence for the effectiveness of shh in stem cell‐based therapy in vivo.
Source: British Journal of Pharmacology - December 23, 2014 Category: Drugs & Pharmacology Authors: Han Na Suh, Ho Jae Han Tags: RESEARCH PAPER Source Type: research

Smoothened activates breast cancer stem-like cell and promotes tumorigenesis and metastasis of breast cancer
Publication date: Available online 3 October 2014 Source:Biomedicine & Pharmacotherapy Author(s): Lixia Wang , Wei Duan , Le Kang , Jun Mao , Xiaotang Yu , Shujun Fan , Lianhong Li , Yajun Tao Smoothened (Smo) is a G protein-coupled receptor protein encoded by the Smo gene of the hedgehog signalling pathway, which is thought to play an important role in maintaining organ patterning, cell differentiation and self-renewal. The possible role of Smo in the process of tumorigenesis and metastasis of breast cancer still remains unclear. The present experiments were to investigate the effect of Smo on activating breast ...
Source: Biomedicine and Pharmacotherapy - November 1, 2014 Category: Drugs & Pharmacology Source Type: research