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Therapy: Immunotherapy

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Total 36235 results found since Jan 2013.

Expression Levels of IL-17A, IL-17F, IL-17RA, and IL-17RC in Prostate Cancer with Taking into Account the Histological Grade according to Gleason Scale in Comparison to Benign Prostatic Hyperplasia: In Search of New Therapeutic Options.
Authors: Janiczek M, Szylberg Ł, Antosik P, Kasperska A, Marszałek A Abstract Prostate cancer (PCa) is the second most commonly diagnosed malignant tumor and the fifth leading cause of cancer death in men in the world. The most common types of tumors are adenocarcinomas. Prostate cancer is a slow-growing cancer. The incidence increases with age. Evaluation of proinflammatory factors such as IL-17A, IL-17F, IL-17RA, and IL-17RC expression makes it possible to assess the impact of inflammatory process on progression of PCa. The aim of the study was to retrospectively assess the histological material of PCa divided ...
Source: Journal of Immunology Research - June 17, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Cancers, Vol. 13, Pages 19: Immunocompetent Mouse Models in the Search for Effective Immunotherapy in Glioblastoma
Coosemans Glioblastoma (GBM) is the most aggressive intrinsic brain tumor in adults. Despite maximal therapy consisting of surgery and radio/chemotherapy, GBM remains largely incurable with a median survival of less than 15 months. GBM has a strong immunosuppressive nature with a multitude of tumor and microenvironment (TME) derived factors that prohibit an effective immune response. To date, all clinical trials failed to provide lasting clinical efficacy, despite the relatively high success rates of preclinical studies to show effectivity of immunotherapy. Various factors may explain this discrepancy, including the in...
Source: Cancers - December 23, 2020 Category: Cancer & Oncology Authors: Roxanne Wouters Sien Bevers Matteo Riva Frederik De Smet An Coosemans Tags: Review Source Type: research

Immersion in the search for effective cancer immunotherapies
Mol Med. 2021 Jun 16;27(1):63. doi: 10.1186/s10020-021-00321-3.NO ABSTRACTPMID:34134616 | DOI:10.1186/s10020-021-00321-3
Source: Molecular Medicine - June 17, 2021 Category: Molecular Biology Authors: Steven A Rosenberg Source Type: research

Correction to: A Journey in Science: Immersion in the search for effective cancer immunotherapies
Mol Med. 2021 Nov 2;27(1):140. doi: 10.1186/s10020-021-00405-0.NO ABSTRACTPMID:34727884 | DOI:10.1186/s10020-021-00405-0
Source: Molecular Medicine - November 3, 2021 Category: Molecular Biology Authors: Steven A Rosenberg Source Type: research

Strategies employed to evade the host immune response and the mechanism of drug resistance in Mycobacterium tuberculosis: In search of finding new targets
This article provides an in-depth and critical analysis of various strategies employed by the drug-resistant M. tuberculosis to escape the host immune response, as a result of which this bacterium persists in the host for a longer period of time and leads to the development of tuberculosis infection. Furthermore, we also discussed the new targets for the effective treatment of drug resistant tuberculosis.PMID:34951359 | DOI:10.2174/1389201023666211222164938
Source: Current Pharmaceutical Biotechnology - December 24, 2021 Category: Biotechnology Authors: Bashir Ahmed Sheikh Basharat A Bhat Zahoor Ahmad Manzoor A Mir Source Type: research

Immunomodulatory Effect of < em > Lycium barbarum < /em > Polysaccharides against Liver Fibrosis Based on the Intelligent Medical Internet of Things
This study mainly explores the immunomodulatory effect of Lycium barbarum polysaccharides against liver fibrosis based on the intelligent medical Internet of Things. This measure emphasizes that the current effective methods and methods for the treatment of liver cancer are mainly combined treatments of Western medicine and Chinese medicine. These treatments have a certain effect in preventing liver cancer, reducing recurrence, and reducing side effects. Among them, chemotherapy has unique advantages in improving the quality of life and prolonging survival. With the development of medical science and technology, the clinic...
Source: Cancer Control - February 7, 2022 Category: Cancer & Oncology Authors: Yanzhen Han Yan Zhou Tieying Shan Wei Li Haiping Liu Source Type: research

Tertiary lymphoid structures as unique constructions associated with the organization, education, and function of tumor-infiltrating immunocytes
J Zhejiang Univ Sci B. 2022 Oct 15;23(10):812-822. doi: 10.1631/jzus.B2200174.ABSTRACTTertiary lymphoid structures (TLSs) are formations at sites with persistent inflammatory stimulation, including tumors. These ectopic lymphoid organs mainly consist of chemo-attracting B cells, T cells, and supporting dendritic cells (DCs). Mature TLSs exhibit functional organization for the optimal development and collaboration of adaptive immune response, delivering an augmented effect on the tumor microenvironment (TME). The description of the positive correlation between TLSs and tumor prognosis is reliable only under a certain condit...
Source: J Zhejiang Univ Sci ... - October 13, 2022 Category: Science Authors: Jing Chen Jian Chen Lie Wang Source Type: research