Filtered By:
Specialty: Environmental Health

This page shows you your search results in order of date. This is page number 12.

Order by Relevance | Date

Total 205 results found since Jan 2013.

SET Domain-Containing Protein 5 Enhances the Cell Stemness of Non-Small Cell Lung Cancer via the PI3K/Akt/mTOR Pathway
CONCLUSION: In this study, SETD5 promoted the cancer stem cell property of NSCLC through mitigating the activation of the PI3K/Akt/mTOR pathway, suggesting a candidate target role for SETD5 in NSCLC treatment.PMID:33822517 | DOI:10.1615/JEnvironPatholToxicolOncol.2021036991
Source: Journal of Environmental Pathology, Toxicology and Oncology - April 6, 2021 Category: Environmental Health Authors: Qing Chen Zhuo Sun Jinfang Li Donghua Zhang Bin Guo Tongwen Zhang Source Type: research

MicroRNA-191 blocking the translocation of GLUT4 is involved in arsenite-induced hepatic insulin resistance through inhibiting the IRS1/AKT pathway
Ecotoxicol Environ Saf. 2021 Mar 17;215:112130. doi: 10.1016/j.ecoenv.2021.112130. Online ahead of print.ABSTRACTEnvironmental exposure to arsenic can cause a variety of health problems. Epidemiological and experimental studies have established a diabetogenic role for arsenic, but the mechanisms responsible for arsenic-induced impairment of insulin action are unclear. MicroRNAs (miRNAs) are involved in various metabolic disorders, particularly in the development of insulin resistance. The present study investigated whether arsenite, an active form of arsenic, induces hepatic insulin resistance and the mechanisms underlying...
Source: Ecotoxicology and Environmental Safety - March 20, 2021 Category: Environmental Health Authors: Wenqi Li Lu Wu Qian Sun Qianlei Yang Junchao Xue Ming Shi Huanwen Tang Jingshu Zhang Qizhan Liu Source Type: research

Environmental cadmium exposure induces fetal growth restriction via triggering PERK-regulated mitophagy in placental trophoblasts.
This study designed in vitro and in vivo experiments to explore the role of placental mitophagy in Cd-impaired fetal growth. Based on our case-control study, we also investigated the association of placental mitophagy with reduced progesterone (P4) level and all-cause FGR. We firstly found environmental Cd exposure lowered the P4 content in maternal sera, placentae and amnioticfluids of mice. The level of three mitochondrial P4 synthases, including StAR, CYP11A1 and 3β-HSD, was also reduced in Cd-treated placentae. Furthermore, Cd triggered mitophagy, as determined by the degradation of two mitochondrial proteins HSP60 an...
Source: Environment International - December 18, 2020 Category: Environmental Health Authors: Zhu HL, Shi XT, Xu XF, Xiong YW, Yi SJ, Zhou GX, Liu WB, Huang MM, Gao L, Zhang C, Zhao LL, Xu DX, Wang H Tags: Environ Int Source Type: research

Drp1-dependent mitochondrial fission contributes to Cr(VI)-induced mitophagy and hepatotoxicity.
Abstract Hexavalent chromium [Cr(VI)] is seriously harmful to ecosystems and living organisms due to its strong toxicity. Role of dynamin-related protein 1 (Drp1) and Drp1-associated mitochondrial fragmentation in mitophagy and cytotoxicity after Cr(VI) exposure has not been clarified so far. We confirmed that Cr(VI) caused mitochondrial fission by up-regulating Drp1 expression and enhancing Drp1 mitochondrial translocation. By applying the intracellular Ca2+ antagonist BAPTA-AM and mitochondrial Ca2+ antagonist Ru360, we demonstrated that Cr(VI)-induced excessive mitochondrial fission was in a Ca2+-Drp1 dependent...
Source: Ecotoxicology and Environmental Safety - September 7, 2020 Category: Environmental Health Authors: Zhang Y, Ma Y, Xiao Y, Lu C, Xiao F Tags: Ecotoxicol Environ Saf Source Type: research

Ferroptosis mediated by the interaction between Mfn2 and IRE α promotes arsenic-induced nonalcoholic steatohepatitis.
Ferroptosis mediated by the interaction between Mfn2 and IREα promotes arsenic-induced nonalcoholic steatohepatitis. Environ Res. 2020 Jun 23;188:109824 Authors: Wei S, Qiu T, Wang N, Yao X, Jiang L, Jia X, Tao Y, Zhang J, Zhu Y, Yang G, Liu X, Liu S, Sun X Abstract Exposure to arsenic is a risk factor for nonalcoholic steatohepatitis (NASH). Ferroptosis is a form of regulated cell death defined by the accumulation of lipid peroxidation. In the current study, we observed the occurrence of ferroptosis in arsenic-induced NASH by assessing ferroptosis related hallmarks. In vitro, we found that ferrostat...
Source: Environmental Research - June 22, 2020 Category: Environmental Health Authors: Wei S, Qiu T, Wang N, Yao X, Jiang L, Jia X, Tao Y, Zhang J, Zhu Y, Yang G, Liu X, Liu S, Sun X Tags: Environ Res Source Type: research

IJERPH, Vol. 17, Pages 2078: Triple-Negative Breast Cancer: A Review of Conventional and Advanced Therapeutic Strategies
apia Ramirez Triple-negative breast cancer (TNBC) cells are deficient in estrogen, progesterone and ERBB2 receptor expression, presenting a particularly challenging therapeutic target due to their highly invasive nature and relatively low response to therapeutics. There is an absence of specific treatment strategies for this tumor subgroup, and hence TNBC is managed with conventional therapeutics, often leading to systemic relapse. In terms of histology and transcription profile these cancers have similarities to BRCA-1-linked breast cancers, and it is hypothesized that BRCA1 pathway is non-functional in this type of b...
Source: International Journal of Environmental Research and Public Health - March 19, 2020 Category: Environmental Health Authors: Mauricio A. Medina Goldie Oza Ashutosh Sharma L.G. Arriaga Jos é Manuel Hernández Hernández Vincent M. Rotello Jose Tapia Ramirez Tags: Review Source Type: research

Selenium ameliorates cadmium-induced mouse leydig TM3 cell apoptosis via inhibiting the ROS/JNK /c-jun signaling pathway.
In this study, we hypothesized that the reactive oxygen species (ROS)-mediated c-jun N-terminal kinase (JNK) signaling pathway is involved in anti-apoptosis of selenium against cadmium in TM3 cells. We found that exposure to cadmium caused evident cytotoxicity, in which cell viability was inhibited, followed by inducement of apoptosis. Moreover, the level of ROS generation was elevated, leading to the phosphorylation of JNK. In addition, following cadmium exposure, the nuclear transcription factor c-jun was significantly activated, which led to increased expression of downstream gene c-jun, resulting in downstream activati...
Source: Ecotoxicology and Environmental Safety - February 10, 2020 Category: Environmental Health Authors: Ren X, Wang S, Zhang C, Hu X, Zhou L, Li Y, Xu L Tags: Ecotoxicol Environ Saf Source Type: research

Arsenic Induces Dysfunctional Autophagy via Dual Regulation of mTOR Pathway and Beclin1-Vps34/PI3K Complex in MLTC-1 Cells
Publication date: Available online 3 February 2020Source: Journal of Hazardous MaterialsAuthor(s): Chen Liang, Zhiyuan Feng, Ram Kumar Manthari, Chong Wang, Yongli Han, Weixiang Fu, Jundong Wang, Jianhai ZhangAbstractArsenic poisoning and induced potential lesion is a global concern. However, the exact mechanisms underlying its toxicity especially in male reproductive system still remain unclear. Hence, this study aimed to explore the roles of mTOR and Beclin1-Vps34/PI3K complex during As-induced-toxicity using Rapamycin (mTOR inhibitor), Beclin1 siRNA and 3-methyladenine (3-MA, Vps34/PI3K inhibitor) in testicular stromal ...
Source: Journal of Hazardous Materials - February 5, 2020 Category: Environmental Health Source Type: research

Notch Pathway Up-regulation via Curcumin Mitigates Bisphenol-A (BPA) Induced Alterations in Hippocampal Oligodendrogenesis
Publication date: Available online 8 January 2020Source: Journal of Hazardous MaterialsAuthor(s): Ankit Tandon, Sangh Jyoti Singh, Manjeet Gupta, Nivedita Singh, Jai Shankar, Nidhi Arjaria, Shweta Goyal, Rajnish Kumar ChaturvediAbstractCNS myelination process involves proliferation and differentiation of oligodendrocyte progenitor cells (OPCs). Defective myelination causes onset of neurological disorders. Bisphenol-A (BPA), a component of plastic items, exerts adverse effects on human health. Our previous studies indicated that BPA impairs neurogenesis and myelination process stimulating cognitive dysfunctions. But, the un...
Source: Journal of Hazardous Materials - January 9, 2020 Category: Environmental Health Source Type: research

Small interfering RNA targeting of peroxiredoxin Ⅱ gene enhances formaldehyde-induced toxicity in bone marrow cells isolated from BALB/c mice.
CONCLUSION: These results demonstrated that PrxⅡ gene was involved in FA-induced bone marrow toxicity, and siRNA targeting of PrxⅡcould enhance this toxic process. PMID: 31176251 [PubMed - as supplied by publisher]
Source: Ecotoxicology and Environmental Safety - June 4, 2019 Category: Environmental Health Authors: Yu G, Zhang Y, Liu S, Fan L, Yang Y, Huang Y, Song J Tags: Ecotoxicol Environ Saf Source Type: research

Hydrogen sulfide exposure triggers chicken trachea inflammatory injury through oxidative stress-mediated FOS/IL8 signaling
Publication date: 15 April 2019Source: Journal of Hazardous Materials, Volume 368Author(s): Menghao Chen, Xiaojing Li, Qunxiang Shi, Ziwei Zhang, Shiwen XuAbstractHydrogen sulfide (H2S) is well known to cause irritation and damage to airway following inhalation, but the mechanism by which H2S contributes to airway toxicity is unclear. In order to assess the respiratory toxicity of H2S inhalation in chicken trachea, we investigated the change of oxidative stress parameters, tracheal tissue structure and transcriptome profiles of chicken trachea exposed to H2S for 42 days. The results showed H2S exposure induced oxidative st...
Source: Journal of Hazardous Materials - January 24, 2019 Category: Environmental Health Source Type: research

Investigation of the differential transport mechanism of cinnabar and mercury containing compounds
ConclusionThis study demonstrates that differential transport and accumulation of mercury in 293 T cells exists among cinnabar and the three mercury-containing compounds HgCl2, MeHg and HgS, leading to distinct sensitivity to mercury induced cytotoxicity. The kidney organic anion transporters OAT1 and OAT3 are partially involved in the regulation of the transport of HgCl2 and MeHg, but not in the regulation of the transport of cinnabar.
Source: Environmental Toxicology and Pharmacology - December 27, 2018 Category: Environmental Health Source Type: research

Initial evidence of functional siRNA machinery in dinoflagellates
This study was aimed to adopt the RNA interference (RNAi) gene-silencing tool for dinoflagellate research, and to investigate the potential effects of RNAi-based silencing of proton-pump rhodopsin and CO2-fixing enzyme Rubisco encoding genes in dinoflagellates. It was found that RNAi treatment caused a significant decrease in growth rate in both species. Compared with the non- endogenous target (GFP-siRNA) and the blank control, RNAi treatments also suppressed the expression of the target genes. These results constitute the first experimental evidence of the existence and operation of siRNA in two species of dinoflagellate...
Source: Harmful Algae - December 2, 2018 Category: Environmental Health Source Type: research

GPER/Hippo-YAP signal is involved in Bisphenol S induced migration of triple negative breast cancer (TNBC) cells
Publication date: 5 August 2018 Source:Journal of Hazardous Materials, Volume 355 Author(s): Qianqian Deng, Guanmin Jiang, Yingmin Wu, Jiexin Li, Weiting Liang, Likun Chen, Qiao Su, Wuguo Li, Jun Du, Chris K.C. Wong, Zhuojia Chen, Hongsheng Wang Nowadays, risk factors of triple-negative breast cancer (TNBC) metastasis are not well identified. Our present study reveals that an industrial chemical, bisphenol S (BPS), can promote the migration, but not the proliferation, of TNBC cells in vitro. BPS activates YAP, a key effector of Hippo pathway, by inhibiting its phosphorylation, which promotes YAP nuclear accumulation and u...
Source: Journal of Hazardous Materials - May 12, 2018 Category: Environmental Health Source Type: research

Epigallocatechin-3-gallate attenuates microcystin-LR-induced apoptosis in human umbilical vein endothelial cells through activation of the NRF2/HO-1 pathway.
In this study, we investigated whether the nuclear factor erythroid-like 2 (NRF2)/heme oxygenase-1 (HO-1) pathway, which regulates antioxidant transcriptional regulation of oxidative stress and apoptosis, is involved in this process. Mitochondrial membrane potential (MMP) and caspase-3/-9 activities were evaluated in HUVECs by JC-1 staining and colorimetric activity assay, and a DCFH-DA fluorescent probe assay was used to quantitate reactive oxygen species (ROS) generation. The effects of MC-LR, EGCG, NF2, and HO-1 on HUVEC apoptosis were explored by western blotting and small interfering RNA (siRNA) analyses. MC-LR treatm...
Source: Environmental Pollution - April 18, 2018 Category: Environmental Health Authors: Shi J, Zhang M, Zhang L, Deng H Tags: Environ Pollut Source Type: research