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Specialty: Urology & Nephrology

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Total 430 results found since Jan 2013.

Interferon-Stimulated Gene 15, a Type I Interferon-Dependent Transcript, Is Involved in a Negative Feedback Loop in Innate Immune Reactions in Human Mesangial Cells
Conclusion: Since unconjugated free ISG15 negatively regulates the phosphorylation of STAT1 and its downstream reactions, ISG15 dysregulation may be involved in the pathogenesis of glomerular inflammation. We believe that suitable interventions in these innate immune cascades is desirable for the future therapeutic strategies for glomerulonephritis.Nephron
Source: Nephron - February 5, 2016 Category: Urology & Nephrology Source Type: research

Nedd4-2 but not Nedd4-1 is critical for protein kinase C-regulated ubiquitination, expression, and transport activity of human organic anion transporter 1
In conclusion, this is the first demonstration that both Nedd4-1 and Nedd4-2 are important regulators for hOAT1 ubiquitination, expression, and function. Yet they play distinct roles, as Nedd4-2 but not Nedd4-1 is a critical mediator for PKC-regulated hOAT1 ubiquitination, expression, and transport activity.
Source: AJP: Renal Physiology - April 30, 2016 Category: Urology & Nephrology Authors: Xu, D., Wang, H., Zhang, Q., You, G. Tags: ARTICLES Source Type: research

Delayed treatment with fenofibrate protects against high-fat diet-induced kidney injury in mice: the possible role of AMPK-autophagy.
Abstract Fenofibrate activates not only peroxisome proliferator-activated receptor α (PPARα) but also adenosine monophosphate-activated protein kinase (AMPK). AMPK-mediated cellular responses protect kidney from high-fat diet (HFD)-induced injury, and autophagy resulting from AMPK activation has been regarded as a stress-response mechanism. Thus, the present study examined the role of AMPK and autophagy in the renotherapeutic effects of fenofibrate. C57BL/6J mice were divided into 3 groups: normal diet (ND), HFD, and HFD+fenofibrate (HFD+FF). Fenofibrate was administered 4 weeks after the initiation of the HFD w...
Source: Am J Physiol Renal P... - July 26, 2016 Category: Urology & Nephrology Authors: Sohn M, Kim K, Uddin MJ, Lee G, Hwang I, Kang H, Kim H, Lee JH, Ha H Tags: Am J Physiol Renal Physiol Source Type: research

Interferon (IFN)-Induced Protein 35 (IFI35), a Type I Interferon-Dependent Transcript, Upregulates Inflammatory Signaling Pathways by Activating Toll-Like Receptor 3 in Human Mesangial Cells
Conclusion:Regional expression of IFI35 and its dysregulation may be involved in the pathogenesis of glomerular inflammation in CKD.Kidney Blood Press Res 2016;41:635-642
Source: Kidney and Blood Pressure Research - September 16, 2016 Category: Urology & Nephrology Source Type: research

Role and Association of Inflammatory and Apoptotic Caspases in Renal Tubulointerstitial Fibrosis
Conclusions:Our study associated inflammatory and apoptotic caspases in TIF for the first time and we further confirmed that caspase-1 activation is an upstream event of apoptotic caspase-7 induction in TIF triggered by UUO and in TECs mediated by TGF- β1 induced transdifferentiation.Kidney Blood Press Res 2016;41:643-653
Source: Kidney and Blood Pressure Research - September 19, 2016 Category: Urology & Nephrology Source Type: research

Mucin-1 Increases Renal TRPV5 Activity In Vitro, and Urinary Level Associates with Calcium Nephrolithiasis in Patients
Hypercalciuria is a major risk factor for nephrolithiasis. We previously reported that Uromodulin (UMOD) protects against nephrolithiasis by upregulating the renal calcium channel TRPV5. This channel is crucial for calcium reabsorption in the distal convoluted tubule (DCT). Recently, mutations in the gene encoding Mucin-1 (MUC1) were found to cause autosomal dominant tubulointerstitial kidney disease, the same disease caused by UMOD mutations. Because of the similarities between UMOD and MUC1 regarding associated disease phenotype, protein structure, and function as a cellular barrier, we examined whether urinary MUC1 also...
Source: Journal of the American Society of Nephrology : JASN - October 30, 2016 Category: Urology & Nephrology Authors: Nie, M., Bal, M. S., Yang, Z., Liu, J., Rivera, C., Wenzel, A., Beck, B. B., Sakhaee, K., Marciano, D. K., Wolf, M. T. F. Tags: Clinical Research Source Type: research

Simvastatin Up ‐Regulates Annexin A10 That Can Inhibit the Proliferation, Migration, and Invasion in Androgen‐Independent Human Prostate Cancer Cells
CONCLUSIONOur results suggest that statins inhibit the proliferation, migration, and invasion of androgen‐independent prostate cancer cells by up‐regulation of ANXA10. Additionally, it is possible that S100A4 plays a role in these effects. Statins may be beneficial in the prevention and/or treatment of prostate cancer. Prostate © 2016 Wiley Periodicals, Inc.
Source: The Prostate - November 7, 2016 Category: Urology & Nephrology Authors: Yoshiyuki Miyazawa, Yoshitaka Sekine, Haruo Kato, Yosuke Furuya, Hidekazu Koike, Kazuhiro Suzuki Tags: Original Article Source Type: research

Delayed treatment with fenofibrate protects against high-fat diet-induced kidney injury in mice: the possible role of AMPK autophagy
Fenofibrate activates not only peroxisome proliferator-activated receptor-α (PPARα) but also adenosine monophosphate-activated protein kinase (AMPK). AMPK-mediated cellular responses protect kidney from high-fat diet (HFD)-induced injury, and autophagy resulting from AMPK activation has been regarded as a stress-response mechanism. Thus the present study examined the role of AMPK and autophagy in the renotherapeutic effects of fenofibrate. C57BL/6J mice were divided into three groups: normal diet (ND), HFD, and HFD + fenofibrate (HFD + FF). Fenofibrate was administered 4 wk after the initiation of the HFD when ...
Source: AJP: Renal Physiology - February 7, 2017 Category: Urology & Nephrology Authors: Sohn, M., Kim, K., Uddin, M. J., Lee, G., Hwang, I., Kang, H., Kim, H., Lee, J. H., Ha, H. Tags: RESEARCH ARTICLE Source Type: research

Fibrinogen links podocyte injury with Toll ‐like receptor 4 and is associated with disease activity in FSGS patients
ConclusionsFg induced podocytes injury via the TLR4‐p38 MAPK‐NF‐κB p65 pathway. In FSGS patients, urinary Fg levels reflect therapeutic response to prednisone and disease activity.
Source: Nephrology - April 13, 2017 Category: Urology & Nephrology Authors: Hongtian Wang, Chunxia Zheng, Xiaodong Xu, Yue Zhao, Yinghui Lu, Zhihong Liu Tags: Original Article Source Type: research

Beneficial Effects of Myo-Inositol Oxygenase Deficiency in Cisplatin-Induced AKI
Overexpression of the proximal tubular enzyme myo-inositol oxygenase (MIOX) induces oxidant stress in vitro. However, the relevance of MIOX to tubular pathobiology remains enigmatic. To investigate the role of MIOX in cisplatin-induced tubular AKI, we generated conditional MIOX-overexpressing transgenic (MIOX-TG) mice and MIOX-knockout (MIOX–/–) mice with tubule-specific MIOX overexpression or knockout, respectively. Compared with cisplatin-treated wild-type (WT) mice, cisplatin-treated MIOX-TG mice had even greater increases in urea, creatinine, and KIM-1 levels and more tubular injury and apoptosis, but these...
Source: Journal of the American Society of Nephrology : JASN - April 28, 2017 Category: Urology & Nephrology Authors: Dutta, R. K., Kondeti, V. K., Sharma, I., Chandel, N. S., Quaggin, S. E., Kanwar, Y. S. Tags: Basic Research Source Type: research

Role for reactive oxygen species in flow stimulated inner medullary collecting duct endothelin-1 production.
Abstract Inner medullary collecting duct (IMCD)-derived endothelin-1 (ET-1) is stimulated by volume expansion, in part through augmented luminal flow, whereupon it can elicit natriuresis and diuresis. Since flow can alter nitric oxide (NO) and reactive oxygen species (ROS), both of which can affect collecting duct salt transport, we asked whether NO and/or ROS mediate flow-stimulated IMCD ET-1. Mouse IMCD3 cells were exposed to flow and ET-1/GAPDH mRNA assessed. A shear stress of 10 dyne/cm2 for 1 hr increased ET-1 mRNA by 4-fold compared to no flow (ET-1 flow response). Global NO synthase (NOS) inhibition (L-NAME...
Source: Am J Physiol Renal P... - May 17, 2017 Category: Urology & Nephrology Authors: Wheatley W, Kohan DE Tags: Am J Physiol Renal Physiol Source Type: research

Regulation of PDZ domain containing 1 (PDZK1) Expression by Hepatocyte Nuclear Factor 1 alpha (HNF1 α) in Human Kidney.
Regulation of PDZ domain containing 1 (PDZK1) Expression by Hepatocyte Nuclear Factor 1 alpha (HNF1α) in Human Kidney. Am J Physiol Renal Physiol. 2017 Jul 19;:ajprenal.00650.2016 Authors: Prestin K, Hussner J, Ferreira C, Seibert I, Breitung V, Zimmermann U, Meyer Zu Schwabedissen HE Abstract In the renal proximal tubule the secretion and reabsorption of glomerularly filtrated compounds is realized by a functional network of uptake and efflux transporters. The activity and localization of several transporters expressed at the apical tubular membrane is regulated by the membrane associated protein PD...
Source: Am J Physiol Renal P... - July 19, 2017 Category: Urology & Nephrology Authors: Prestin K, Hussner J, Ferreira C, Seibert I, Breitung V, Zimmermann U, Meyer Zu Schwabedissen HE Tags: Am J Physiol Renal Physiol Source Type: research

Role for reactive oxygen species in flow-stimulated inner medullary collecting duct endothelin-1 production
Inner medullary collecting duct (IMCD)-derived endothelin-1 (ET-1) is stimulated by volume expansion, in part through augmented luminal flow, whereupon it can elicit natriuresis and diuresis. Since flow can alter nitric oxide (NO) and reactive oxygen species (ROS), both of which can affect collecting duct salt transport, we asked whether NO and/or ROS mediate flow-stimulated IMCD ET-1. Mouse IMCD3 cells were exposed to flow, and ET-1/GAPDH mRNA was assessed. A shear stress of 10 dyn/cm2 for 1 h increased ET-1 mRNA by fourfold compared with no flow (ET-1 flow response). Global NO synthase (NOS) inhibition [NG-nitro-l-argini...
Source: AJP: Renal Physiology - August 10, 2017 Category: Urology & Nephrology Authors: Wheatley, W., Kohan, D. E. Tags: RESEARCH ARTICLE Source Type: research

The Circadian expression of Piezo1, TRPV4, Connexin26, and VNUT, associated with the expression levels of the clock genes in mouse primary cultured urothelial cells
ConclusionsWe demonstrated that the time‐dependent gene expressions, including clock genes, mechano‐sensors, and ARMM, were reproducible in UCs. These findings demonstrated that UCs have the potential to progress research into the circadian functions of the lower urinary tract regulated by clock genes.
Source: Neurourology and Urodynamics - September 1, 2017 Category: Urology & Nephrology Authors: Tatsuya Ihara, Takahiko Mitsui, Yuki Nakamura, Mie Kanda, Sachiko Tsuchiya, Satoru Kira, Hiroshi Nakagomi, Norifumi Sawada, Yuri Hirayama, Keisuke Shibata, Eiji Shigetomi, Yoichi Shinozaki, Mitsuharu Yoshiyama, Atsuhito Nakao, Masayuki Takeda, Schuichi Ko Tags: ORIGINAL BASIC SCIENCE ARTICLE Source Type: research

Contribution of myo-inositol oxygenase in age: rage mediated renal tubulo-interstitial injury in the context of diabetic nephropathy.
CONTRIBUTION OF MYO-INOSITOL OXYGENASE IN AGE: RAGE MEDIATED RENAL TUBULO-INTERSTITIAL INJURY IN THE CONTEXT OF DIABETIC NEPHROPATHY. Am J Physiol Renal Physiol. 2017 Sep 20;:ajprenal.00434.2017 Authors: Sharma I, Tupe RS, Wallner AK, Kanwar YS Abstract Advanced glycation end products (AGEs) play a role in pathogenesis of diabetic nephropathy (DN). Myo-inositol Oxygenase (MIOX) has been implicated in tubulo-interstitial injury in the context of DN. We investigated the effect of AGEs on MIOX expression and delineated mechanisms that lead to tubulo-interstitial injury. Status of MIOX, RAGE and relevant ...
Source: Am J Physiol Renal P... - September 20, 2017 Category: Urology & Nephrology Authors: Sharma I, Tupe RS, Wallner AK, Kanwar YS Tags: Am J Physiol Renal Physiol Source Type: research