Role and Association of Inflammatory and Apoptotic Caspases in Renal Tubulointerstitial Fibrosis

Conclusions:Our study associated inflammatory and apoptotic caspases in TIF for the first time and we further confirmed that caspase-1 activation is an upstream event of apoptotic caspase-7 induction in TIF triggered by UUO and in TECs mediated by TGF- β1 induced transdifferentiation.Kidney Blood Press Res 2016;41:643-653
Source: Kidney and Blood Pressure Research - Category: Urology & Nephrology Source Type: research