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Specialty: Reproduction Medicine

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Total 316 results found since Jan 2013.

Estradiol promotes cells invasion by activating {beta}-catenin signaling pathway in endometriosis
Endometriosis is an estrogen-dependent disease that involves the adhesion, invasion, and angiogenesis of endometrial tissues outside of the uterine cavity. We hypothesized that a link exists between estrogen and beta-catenin (β-catenin) signaling in the pathogenesis of endometriosis. Human endometrial stromal cells (HESCs) were separated from eutopic endometrial tissues that were obtained from patients with endometriosis. β-catenin expression and cells invasiveness ability were up-regulated by 17β-estradiol (E2) in an estrogen receptor (ESR)-dependent manner, whereas β-catenin siRNA abrogated this pheno...
Source: Reproduction - November 4, 2015 Category: Reproduction Medicine Authors: Xiong, W., Zhang, L., Yu, L., Xie, W., Man, Y., Xiong, Y., Liu, H., Liu, Y. Tags: Research Source Type: research

RAF1 is increased in labouring myometrium and modulates inflammation-induced pro-labour mediators
In conclusion, IL1B induces the expression and secretion of pro-labour mediators through the RAF1–MAPK1–NF-B signalling pathway. TNF, on the other hand, regulates pro-labour mediators through the RAF1–NF-B signalling pathway via an MAPK1-independent mechanism.
Source: Reproduction - February 23, 2016 Category: Reproduction Medicine Authors: Lappas, M. Tags: Research Source Type: research

Overexpression of chloride channel-3 is associated with the increased migration and invasion ability of ectopic endometrial cells from patients with endometriosis
STUDY QUESTION Is chloride channel-3 (ClC-3) involved in regulating the biological behavior of endometrial stromal cells (ESCs)? SUMMARY ANSWER ClC-3 promotes endometriotic cell migration and invasion. WHAT IS KNOWN ALREADY ClC-3 plays a significant role in the migration and invasion of various kinds of cells. STUDY DESIGN, SIZE, DURATION An in vitro investigation of the effect of ClC-3 on the migration and invasion of ectopic ESCs from patients with endometriosis. PARTICIPANTS/MATERIALS, SETTING, METHODS The ectopic and eutopic endometrial samples from 43 female patients with endometriosis and the endometrial samples ...
Source: Human Reproduction - April 20, 2016 Category: Reproduction Medicine Authors: Guan, Y.-t., Huang, Y.-q., Wu, J.-b., Deng, Z.-q., Wang, Y., Lai, Z.-y., Wang, H.-b., Sun, X.-x., Zhu, Y.-l., Du, M.-m., Zhu, L.-y., Chen, L.-x., Wang, L.-w. Tags: Gynaecology Source Type: research

CHD1 Regulates Deposition of Histone Variant H3.3 During Bovine Early Embryonic Development.
The objective of this study was to characterize CHD1 expression and elucidate its functional role in preimplantation development using the bovine model. CHD1 mRNA was elevated after meiotic maturation and remains increased through 16-cell stage followed by a sharp decrease at morula to blastocyst stage. Similarly, immunoblot analysis indicated CHD1 protein level is increased after maturation, maintained at high level after fertilization and declined sharply afterwards. CHD1 mRNA level was partially decreased in response to α-amanitin (RNA polymerase II inhibitor) treatment, suggesting CHD1 mRNA in 8-cell embryos is of bot...
Source: Biology of Reproduction - May 10, 2016 Category: Reproduction Medicine Authors: Zhang K, Rajput SK, Wang S, Folger JK, Knott JG, Smith GW Tags: Biol Reprod Source Type: research

Stathmin 1 plays a role in endometrial decidualisation by regulating hypoxia inducible factor-1? and vascular endothelial growth factor during embryo implantation.
Abstract The aim of the present study was to explore the potential mechanism underlying stathmin 1 (Stmn1) regulation of embryo implantation, as a continuation of previous proteomic research. Adult healthy female mice were mated naturally with fertile males. Murine uterine tissue was collected during the peri-implantation period. Local expression of Stmn1 during embryo implantation was detected by immunohistochemistry (IHC), which showed that Stmn1 was extensively expressed in endometrial glandular epithelium, vascular endothelium, luminal epithelium and the underlying stromal cells at the implantation site on Day...
Source: Reproduction, Fertility, and Development - July 25, 2016 Category: Reproduction Medicine Authors: Gou J, Jia J, Feng J, Zhao X, Yi T, Cui T, Li Z Tags: Reprod Fertil Dev Source Type: research

Interleukin-1 receptor antagonist mediates toll-like receptor 3-induced inhibition of trophoblast adhesion to endometrial cells in vitro
This study has been only done in vitro. Future in vivo studies will confirm our data. WIDER IMPLICATIONS OF THE FINDINGS The findings of this study have a potential clinical application in introducing IL-1RA as one of the diagnostic infertility markers in the endometrium, which can affect the process of embryo adhesion at the time of implantation. Moreover, based on the novel data obtained in the current study, blocking and regulating the MAPK pathway by its inhibitors can be used as a new strategy to prevent and treat virus-induced infertility cases in ART techniques. STUDY FUNDING/COMPETING INTEREST This study was part...
Source: Human Reproduction - August 18, 2016 Category: Reproduction Medicine Authors: Montazeri, M., Sanchez-Lopez, J. A., Caballero, I., Maslehat Lay, N., Elliott, S., Fazeli, A. Tags: Reproductive biology Source Type: research

nm23 regulates decidualization through the PI3K-Akt-mTOR signaling pathways in mice and humans
This study was supported by the National Natural Science Foundation of China (grant nos. 81370731, 31571551 and 31571190), the Science and Technology Project of Chongqing Education Committee (KJ130309), open funding by the Chongqing Institute for Family Planning (1201) and the Excellent Young Scholars of Chongqing Medical University (CQYQ201302). The authors have no conflicts of interest to declare.
Source: Human Reproduction - September 18, 2016 Category: Reproduction Medicine Authors: Zhang, X., Fu, L.-J., Liu, X.-Q., Hu, Z.-Y., Jiang, Y., Gao, R.-F., Feng, Q., Lan, X., Geng, Y.-Q., Chen, X.-M., He, J.-L., Wang, Y.-X., Ding, Y.-B. Tags: Reproductive biology Source Type: research

miR-361-3p regulates FSH by targeting FSHB in a porcine anterior pituitary cell model
FSH plays an essential role in processes involved in human reproduction, including spermatogenesis and the ovarian cycle. While the transcriptional regulatory mechanisms underlying its synthesis and secretion have been extensively studied, little is known about its posttranscriptional regulation. A bioinformatics analysis from our group indicated that a microRNA (miRNA; miR-361-3p) could regulate FSH secretion by potentially targeting the FSHB subunit. Herein, we sought to confirm these findings by investigating the miR-361-3p-mediated regulation of FSH production in primary pig anterior pituitary cells. Gonadotropin-relea...
Source: Reproduction - January 9, 2017 Category: Reproduction Medicine Authors: Ye, R.-S., Li, M., Li, C.-Y., Qi, Q.-E., Chen, T., Cheng, X., Wang, S.-B., Shu, G., Wang, L.-N., Zhu, X.-T., Jiang, Q.-Y., Xi, Q.-Y., Zhang, Y.-L. Tags: Research Source Type: research

WNK lysine deficient protein kinase 1 regulates human endometrial stromal cell decidualization, proliferation and migration in part through mitogen-activated protein kinase 7.
Abstract The differentiation of endometrial stromal cells into decidual cells, termed decidualization, is an integral step in the establishment of pregnancy. The mitogen-activated protein kinase homolog, WNK lysine deficient protein kinase 1 (WNK1), is activated downstream of epidermal growth factor receptor (EGFR) during decidualization. Primary human endometrial stromal cells (HESCs) were subjected to siRNA knockdown of WNK1 followed by in vitro decidualization. This abrogated expression of the decidual marker genes, IGFBP1 and PRL, and prevented adoption of decidual cell morphology. Analysis of the WNK1-depende...
Source: Biology of Reproduction - August 30, 2017 Category: Reproduction Medicine Authors: Adams NR, Vasquez YM, Mo Q, Gibbons W, Kovanci E, DeMayo FJ Tags: Biol Reprod Source Type: research

CDKN1C (P57): one of the determinants of human endometrial stromal cell decidualization.
Abstract Decidualization is regulated by crosstalk of progesterone and the cAMP pathway. It involves extensive reprogramming of gene expression and includes a wide range of functions. To investigate how cell cycle regulatory genes drive the human endometrial stromal cell (ESC) exit cell cycle and enter differentiation, primary cultured ESC was treated with 8-Br-cAMP and MPA and cell cycle distribution was investigated by flow cytometry. High-throughput cell cycle regulatory gene expression was also studied by microarray. To validate the results of microarray chip, immunohistochemistry and semi-quantitative method ...
Source: Biology of Reproduction - January 9, 2018 Category: Reproduction Medicine Authors: Wang L, Yang H, Hu L, Hu D, Ma S, Sun X, Jiang L, Song J, Ji L, Masau JF, Zhang H, Qian K Tags: Biol Reprod Source Type: research

Sex hormones alter the response of Toll-like receptor 3 to its specific ligand in fallopian tube epithelial cells.
Conclusion: These results imply that sex hormones exerted a suppressive effect on the function of TLR3 in the fallopian tube cell line when different concentrations of sex hormones were present. The current results also suggest that estrogen receptor beta and nuclear progesterone receptor B are likely to mediate the hormonal regulation of TLR3, as these two receptors are the main estrogen and progesterone receptors in OE-E6/E7 cell line. PMID: 30538945 [PubMed]
Source: Clinical and Experimental Reproductive Medicine - December 13, 2018 Category: Reproduction Medicine Tags: Clin Exp Reprod Med Source Type: research

Endo-siRNAs regulate early embryonic development by inhibiting transcription of long terminal repeat sequence in pig.
Abstract Activity of some endogenous retroviruses (ERVs) has been proven to be important for development of early mammalian embryo. However, abnormal activation of ERVs can also cause genetic diseases due to their ability to retrotranspose, so the regulatory mechanism to limit transcription of ERVs needs to be clarified. Endogenous small interfering RNA (endo-siRNA) has been reported to protect cells against transposable elements (TEs). Here, we determined the role of ERVs long terminal repeat sequences (LTRs) derived endo-siRNAs (LTR-siRNAs) on inhibition of the activity of ERVs during early embryonic development...
Source: Biology of Reproduction - March 17, 2019 Category: Reproduction Medicine Authors: Kong Q, Quan X, Du J, Tai Y, Liu W, Zhang J, Zhang X, Mu Y, Liu Z Tags: Biol Reprod Source Type: research

FoxO transcription factors 1 regulate mouse preimplantation embryo development
ConclusionsThese results suggest that FOXO transcription factors could contribute to mouse preimplantation embryo development, and it remains to investigate whether they have crucial roles in human preimplantation embryo and infertility.
Source: Journal of Assisted Reproduction and Genetics - August 7, 2019 Category: Reproduction Medicine Source Type: research

CTHRC1 Overexpression Promotes Ectopic Endometrial Stromal Cell Proliferation, Migration and Invasion via Activation of Wnt/β-catenin Pathway
ConclusionsThese findings suggest that CTHRC1 may be partly responsible for the development and progression of endometriosis by increasing EESC proliferation, migration and invasion via Wnt/β-catenin pathway, and thus serves as a diagnostic and therapeutic target for endometriosis.
Source: Reproductive BioMedicine Online - October 10, 2019 Category: Reproduction Medicine Source Type: research

Reduced expression of PD-L1 in autoimmune thyroiditis attenuate trophoblast invasion through ERK/MMP pathway.
CONCLUSION: AIT inhibits ERK/MMP-2 and MMP-9 pathways through PD-L1 reduction, attenuates embryonic trophoblast invasion and ultimalely induces miscarriage ultimately. PMID: 31656199 [PubMed - in process]
Source: Reproductive Biology - October 26, 2019 Category: Reproduction Medicine Authors: Chen M, Gilbert N, Liu H Tags: Reprod Biol Endocrinol Source Type: research