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Total 49 results found since Jan 2013.

Hypoxia promotes extravillous trophoblast cell invasion through the hypoxia-inducible factor urokinase-type plasminogen activator receptor pathway.
Conclusions: The low oxygen-regulated early events of EVT invasion may be mediated by the HIF-1α-uPAR pathway.
Source: Gynecologic and Obstetric Investigation - July 4, 2022 Category: OBGYN Source Type: research

Effect of HSP10 on apoptosis induced by testosterone in cultured mouse ovarian granulosa cells
Abstract: Objective: To investigate the effect of heat shock protein 10 (HSP10) on apoptosis induced by testosterone in granulosa cells (GCs) of mouse ovaries in order to define the possible roles of HSP10 in ovarian pathological development of polycystic ovarian syndrome (PCOS) and hyperandrogenic conditions.Study design: Cultured mouse ovarian GCs were treated with testosterone (10−5mol/l). Apoptosis was assessed using flow cytometry, and proliferation was assessed using the MTT assay. HSP10 expression in the treated GCs was detected by real-time polymerase chain reaction (PCR). HSP10 gene was downregulated in the cult...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - October 7, 2013 Category: OBGYN Authors: Kao-Kao Zhao, Yu-Gui Cui, Ya-Qin Jiang, Jing Wang, Mei Li, Yuan Zhang, Xiang Ma, Fei-Yang Diao, Jia-Yin Liu Tags: Reproductive Medicine and Endocrinology Source Type: research

Heat shock protein 70 is involved in malignant behaviors and chemosensitivities to cisplatin in cervical squamous cell carcinoma cells
ConclusionIt was suggested that HSP70 played functional roles in the progression of uterine cervical SCC, and HSP70 knockdown enhanced chemosensitivities to cisplatin in cervical SCC cells.
Source: Journal of Obstetrics and Gynaecology Research - April 2, 2014 Category: OBGYN Authors: Keiko Yoshidomi, Akihiro Murakami, Kazuyuki Yakabe, Kotaro Sueoka, Shugo Nawata, Norihiro Sugino Tags: Invited Manuscript Source Type: research

Characterization of protocols for primary trophoblast purification, optimized for functional investigation of sFlt-1 and soluble endoglin
Conclusion In conclusion, we present a protocol that yields primary trophoblasts of high purity that produce abundant sFlt-1 and low but detectable levels of sEng. Furthermore, these cells are readily amenable to gene silencing by siRNAs and hence suitable for functional studies.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - February 17, 2015 Category: OBGYN Source Type: research

38-OR Sexual dimorphism in the effect of inflammation on trophoblast function with preeclampsia
Conclusions We find sexual dimorphism in the effect of inflammation on placental miR-210 expression perhaps mediated by the NFκB1 pathway. This may link placental inflammation in preeclampsia to decreased mitochondrial function in pregnancies with a female fetus. Disclosures L. Myatt: None. C. Guo: None. S. Muralimanoharan: None. A. Maloyan: None.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - February 24, 2015 Category: OBGYN Source Type: research

Loss of Akt increases soluble endoglin release from endothelial cells but not placenta
Conclusion This study confirms that the PI3K/Akt cell protection pathway is down regulated in preeclampsia, but demonstrates that this dysregulation is unlikely to be responsible for the excessive placental soluble endoglin release characteristic of preeclampsia.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - March 28, 2016 Category: OBGYN Source Type: research

Cyclin-Dependent Kinase 14 Promotes Cell Proliferation, Migration and Invasion in Ovarian Cancer by Inhibiting Wnt Signaling Pathway
Objective: The study aimed to investigate cyclin-dependent kinase 14 (CDK14) and its co-function with Wnt signaling pathway on cell proliferation, migration and invasion in ovarian cancer.Methods: CDK14 expressions were detected by quantitative real-time polymerase chain reaction. The expressions c-Myc, cyclinD1, PFTK1, ki67 and OGT were examined by Western blot. MTT assay was applied to observe cell proliferation after transfection of pEGFP-N1/CDK14-siRNA and pEGFP-N1 into SKOV3 cells, and scratch test and Transwell assay to observe invasion and migration ability. Transfected tumor model in nude mice was established.Resul...
Source: Gynecologic and Obstetric Investigation - August 9, 2016 Category: OBGYN Source Type: research

WTIP interacts with BRCA2 and is essential for BRCA2 centrosome localization in cervical cancer cell
ConclusionThis study indicates that WTIP interacts with BRCA2 and might be responsible for BRCA2 centrosome localization in cervical cancer cell.
Source: Archives of Gynecology and Obstetrics - October 19, 2016 Category: OBGYN Source Type: research

Small Molecule, Big Prospects: MicroRNA in Pregnancy and Its Complications.
Authors: Cai M, Kolluru GK, Ahmed A Abstract MicroRNAs are small, noncoding RNA molecules that regulate target gene expression in the posttranscriptional level. Unlike siRNA, microRNAs are "fine-tuners" rather than "switches" in the regulation of gene expression; thus they play key roles in maintaining tissue homeostasis. The aberrant microRNA expression is implicated in the disease process. To date, numerous studies have demonstrated the regulatory roles of microRNAs in various pathophysiological conditions. In contrast, the study of microRNA in pregnancy and its associated complications, such as preeclampsia (PE)...
Source: Journal of Pregnancy - July 19, 2017 Category: OBGYN Tags: J Pregnancy Source Type: research

Akt-mTOR Signaling Mediates Abnormalities in the Proliferation and Apoptosis of Ovarian Granulosa Cells in Patients with Polycystic Ovary Syndrome
This study showed that 1 nM of insulin significantly stimulated cell proliferation, induced cell apoptosis, and decreased the telomerase activity in GCs from both the healthy women and PCOS patients (p
Source: Gynecologic and Obstetric Investigation - July 21, 2017 Category: OBGYN Source Type: research

Aberrant SERPINE1 DNA methylation is involved in carboplatin induced epithelial-mesenchymal transition in epithelial ovarian cancer
ConclusionOur study suggested that SERPINE1 may be a promising therapeutic target for chemoresistance.
Source: Archives of Gynecology and Obstetrics - October 3, 2017 Category: OBGYN Source Type: research

Decidual ACVR2A regulates extravillous trophoblast functions of adhesion, proliferation, migration and invasion in vitro
Publication date: Available online 14 November 2017 Source:Pregnancy Hypertension Author(s): Hannah E.J. Yong, Padma Murthi, Bill Kalionis, Rosemary J. Keogh, Shaun P. Brennecke Decidual stromal cells form the largest proportion of maternal cells at the maternal-fetal interface. Our aim was to investigate the role of the pre-eclampsia associated decidual activin receptor, ACVR2A, in regulating trophoblast functions at this interface. St-T1b and HTR-8/SVneo cell lines were used to model decidual stromal and trophoblast cells respectively. St-T1b conditioned medium inhibited HTR-8/SVneo adhesion, proliferation, migration an...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - December 16, 2017 Category: OBGYN Source Type: research

Reduced Methylation Downregulates CD39/ENTPD1 and ZDHHC14 to Suppress Trophoblast Cell Proliferation and Invasion: Implications in Preeclampsia
Publication date: Available online 24 March 2018 Source:Pregnancy Hypertension Author(s): Lisha Zhu, Ruitu Lv, Lingchun Kong, Xiaotian Li Preeclampsia (PE) is a pregnancy-specific syndrome affecting up to 8% of pregnancies worldwide. While PE is a leading cause of maternal and neonatal mortality and morbidity, the pathophysiology of PE is unclear to date. Here, we have verified that dysregulation of CD39/ectonucleoside triphosphate diphosphohydrolase-1 (ENTPD1) and zinc finger DHHC-type containing 14 (ZDHHC14) via DNA methylation plays a vital role in late-onset PE pathology. Our study confirmed the differentially methyla...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - March 24, 2018 Category: OBGYN Source Type: research

Dysfunction of pseudogene PGK1P2 is involved in preeclampsia by acting as a competing endogenous RNA of PGK1
Conclusions We proved that PGK1 and PGK1P2 are a pair of ceRNAs against miR-330-5p and they play a vital role in human decidualization by regulating angiogenesis and glycolysis metabolism. The deficiency of PGK1 and PGK1P2 in the decidua jeopardizes the decidualization process and subsequently might lead to the occurrence of PE. These findings may help in promoting novel predictive, diagnostic and prognostic biomarkers of PE in future.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - May 4, 2018 Category: OBGYN Source Type: research

Effect of Wnt/ β-catenin signal pathway on of matrix metalloproteinase-7 and vascular endothelial growth factor gene expressions in endometriosis.
CONCLUSION: Blocking of Wnt/β-catenin signal pathway caused the decrease of MMP-7 and VEGF expressions, in- dicating that Wnt/β-catenin signal pathway plays an important role in the adhesion, invasion, and metastasis of endometriosis tissues. PMID: 29734552 [PubMed]
Source: Clinical and Experimental Obstetrics and Gynecology - May 10, 2018 Category: OBGYN Tags: Clin Exp Obstet Gynecol Source Type: research