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Vaccination: Malaria Vaccine

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Total 1496 results found since Jan 2013.

In vitro antimalarial activity of inhibitors of the human GTPase Rac1
Antimicrob Agents Chemother. 2021 Nov 1:AAC0149821. doi: 10.1128/AAC.01498-21. Online ahead of print.ABSTRACTMalaria accounts for millions of cases and thousands of deaths every year. In the absence of an effective vaccine, drugs are still the most important tool in the fight against the disease. Plasmodium parasites developed resistance for all the classes of known antimalarial drugs. Thus, the search for antimalarial drugs with novel mechanisms of action is compelling. The human GTPase Rac1 plays a role in parasite invasion of the host cell in many intracellular pathogens. Also in Plasmodium falciparum, it was suggested ...
Source: Antimicrobial Agents and Chemotherapy - November 1, 2021 Category: Microbiology Authors: Silvia Parapini Silvio Paone Emanuela Erba Loredana Cavicchini Manoochehr Pourshaban Francesco Celani Alessandro Contini Sarah D'Alessandro Anna Olivieri Source Type: research

Isolation, Purification, and Characterization of Homogenous Novel Bioactive Protein from < em > Datura stramonium < /em > Stem Exhibited Larvicidal Activity against < em > Anopheles stephensi < /em >
J Trop Med. 2022 Dec 5;2022:1637896. doi: 10.1155/2022/1637896. eCollection 2022.ABSTRACTThe insecticidal resistance of mosquitoes necessitates the development of a natural, safe, and plant-based method for vector control. Unfortunately, there are no effective vaccines or particular medications available to combat malaria; therefore, mosquitoes must be targeted directly. Previous studies have shown the health benefits of Datura stramonium, but its bioactive peptides or proteins are less explored. This is the first study on D. stramonium stem protein used for mosquito larval protein. The present study aimed to identify the ...
Source: Journal of Tropical Medicine - December 15, 2022 Category: Tropical Medicine Authors: Manisha Kirar S P Singh Neelam Sehrawat Source Type: research

The immunity modulation of transforming growth factor- β in malaria and other pathological process
Int Immunopharmacol. 2023 Jul 17;122:110658. doi: 10.1016/j.intimp.2023.110658. Online ahead of print.ABSTRACTThe main causative agent of malaria in humans is Plasmodium falciparum, which is spread through biting Anopheles mosquitoes. Immunoregulation in the host involving the pleiotropic cytokine transforming growth factor-β (TGF-β) has a vital role in controlling the immune response to P. falciparum infection. Based on a search of the published literature, this study investigated the correlation between malaria and immune cells, specifically the role of TGF-β in the immune response. The studies analyzed showed that, w...
Source: International Immunopharmacology - July 19, 2023 Category: Allergy & Immunology Authors: Shuang Wu Qing Nie Shuang Tan Guoyan Liao Yinyi Lv Caohua Lv Guang Chen Shuangchun Liu Source Type: research

Prospects of using community directed intervention strategy in delivering health services among Fulani Nomads in Enugu State, Nigeria
Conclusion: Given the definable organizational structure of the nomads in Enugu State and their desire for modern health intervention, it is feasible to test the CDI strategy for equitable healthcare delivery among nomads. They are willing and capable to participate actively in their own health programmes with minimal support from professional health workers.
Source: International Journal for Equity in Health - April 8, 2013 Category: Global & Universal Authors: Joseph OkeibunorNkechi OnyenehoObioma NwaorguNgozi I¿AronuIjeoma OkoyeFelicia IremekaJohannes Sommerfeld Source Type: research

U.S. reports malaria vaccine breakthrough
U.S. researchers reported a breakthrough Thursday in the search for a vaccine for malaria, the mosquito-borne disease that sickens millions worldwide. More than three dozen volunteers received multiple, intravenous doses of a vaccine produced with a ...
Source: WDSU.com - Health - August 11, 2013 Category: Consumer Health News Source Type: news

Chalcone and Curcumin Derivatives: A Way ahead for Malarial Treatment.
Abstract Malaria has been a major cause of morbidity and mortality in developing countries, particularly in Sub-Saharan Africa and South Asia. The global malaria situation is increasingly being challenging owing to lack of credible malaria vaccine and the emergence of drug resistance to most of the available Antimalarial. They demand search for novel generation of drugs. Versatility and flexibility for structural modification of natural and synthetic analogues of curcumin and chalcone have been explored extensively for designing new antimalarial agent. Recent advances to our knowledge of parasite biology as well a...
Source: Mini Reviews in Medicinal Chemistry - October 25, 2013 Category: Chemistry Authors: Kumar D, Kumar M, Kumar A, Singh SK Tags: Mini Rev Med Chem Source Type: research

Malaria vaccines: past, present and future
The currently available malaria control tools have allowed malaria elimination in many regions but there remain many regions where malaria control has made little progress. A safe and protective malaria vaccine would be a huge asset for malaria control. Despite the many challenges, efforts continue to design and evaluate malaria vaccine candidates. These candidates target different stages in the life cycle of Plasmodia. The most advanced vaccine candidates target the pre-erythrocytic stages in the life cycle of the parasite and include RTS,S/AS01, which has progressed through clinical development to the stage that it may b...
Source: Archives of Disease in Childhood - November 12, 2013 Category: Pediatrics Authors: von Seidlein, L., Bejon, P. Tags: Immunology (including allergy), Drugs: infectious diseases, ADC Global child health, Travel medicine, Tropical medicine (infectious diseases), Vaccination / immunisation Source Type: research

Challenges and prospects for dengue and malaria control in Thailand, Southeast Asia.
Abstract Despite significant advances in the search for potential dengue vaccines and new therapeutic schemes for malaria, the control of these diseases remains difficult. In Thailand, malaria incidence is falling whereas that of dengue is rising, with an increase in the proportion of reported severe cases. In the absence of antiviral therapeutic options for acute dengue, appropriate case management reduces mortality. However, the interruption of transmission still relies on vector control measures that are currently insufficient to curtail the cycle of epidemics. Drug resistance in malaria parasites is increasing...
Source: Trends in Parasitology - November 8, 2013 Category: Parasitology Authors: Corbel V, Nosten F, Thanispong K, Luxemburger C, Kongmee M, Chareonviriyaphap T Tags: Trends Parasitol Source Type: research

TREM2 controls malaria liver stage infection Medical Sciences
Plasmodium liver stage infection is a target of interest for the treatment of and vaccination against malaria. Here we used forward genetics to search for mechanisms underlying natural host resistance to infection and identified triggering receptor expressed on myeloid cells 2 (TREM2) and MHC class II molecules as determinants of...
Source: Proceedings of the National Academy of Sciences - November 26, 2013 Category: Science Authors: Goncalves, L. A., Rodrigues–Duarte, L., Rodo, J., Vieira de Moraes, L., Marques, I., Penha–Goncalves, C. Tags: Biological Sciences Source Type: research

Oxygen distribution in proteins defines functional significance of the genome and proteome of the malaria parasite Plasmodium falciparum 3D7
This article is protected by copyright. All rights reserved.
Source: FEMS Microbiology Letters - December 1, 2013 Category: Microbiology Authors: Balamurugan Palanisamy, Klaus Heese Tags: Research Letter Source Type: research