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Long ‐acting implantable corticosteroid matrix for chronic rhinosinusitis: Results of LANTERN Phase 2 randomized controlled study
ConclusionsLYR-210 is the first implantable sinonasal treatment to achieve up to 24 weeks of benefit from a single administration in surgically naive CRS patients with and without nasal polyps.
Source: International Forum of Allergy and Rhinology - September 18, 2021 Category: Allergy & Immunology Authors: Anders Cervin, Joanne Rimmer, Agnieszka Wrobel, Yogen Abelak, Lindsay Brayton, Yina Kuang Tags: ORIGINAL ARTICLE Source Type: research

Neurological Involvement in Primary Systemic Vasculitis
Conclusion Neurological involvement is a common complication of PSV (Table 1), and neurologists play an important role in the identification and diagnosis of PSV patients with otherwise unexplained neurological symptoms as their chief complaint. This article summarizes the neurological manifestations of PSV and hopes to improve neuroscientists' understanding of this broad range of diseases. TABLE 1 Table 1. Common CNS and PNS involvements of primary systemic vasculitis. Author Contributions SZ conceived the article and wrote the manuscript. DY and GT reviewed and edited the manuscript. All authors ...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Systemic Lupus Erythematosus With Isolated Psychiatric Symptoms and Antinuclear Antibody Detection in the Cerebrospinal Fluid
Conclusion: Some patients with psychiatric syndromes and increased ANA titers may suffer from psychiatric variants of SLE, even if the American College of Rheumatology criteria for SLE are not met. Whether the psychiatric symptoms in our patient represent a prodromal stage with the later manifestation of full-blown SLE or a subtype of SLE with isolated CNS involvement remains unclear. Regardless, early diagnosis and initiation of immunosuppressive treatment are essential steps in preventing further disease progression and organ damage. Intrathecal ANAs with extractable nuclear antigen differentiation may be a more sensitiv...
Source: Frontiers in Psychiatry - April 24, 2019 Category: Psychiatry Source Type: research

The impact of endoscopic sinus surgery on total direct healthcare costs among patients with chronic rhinosinusitis
ConclusionAmong patients who underwent ESS for CRS, total direct healthcare costs, antibiotic usage, and number of imaging studies decreased after surgery, and remained below preoperative levels throughout all 3 years of follow‐up. Oral corticosteroid usage remained stable.
Source: International Forum of Allergy and Rhinology - April 1, 2015 Category: Allergy & Immunology Authors: Patricia L. Purcell, Sara Beck, Greg E. Davis Tags: ORIGINAL ARTICLE Source Type: research

The brain and asthma: what are the linkages?.
Authors: Busse WW Abstract Stress has been associated as an important contributor to asthma in some patients. The mechanisms, however, which underlie this relationship remain unclear. In this review, the role of stress will be examined in relationship to the development of airway inflammation. As will be discussed, stress may not cause inflammation but enhances its expression when it develops to a second signal. In addition, recent studies using function magnetic resonance imaging (fMRI) have shown that specific circuits in the brain, i.e., anterior cingulate cortex and insula, are activated in relationship and int...
Source: Chemical Immunology and Allergy - December 2, 2014 Category: Allergy & Immunology Tags: Chem Immunol Allergy Source Type: research

A case of eosinophilic fasciitis presenting as pitting edema of the lower extremities.
We report a 19-year-old female who presented with pitting edema in both lower extremities. She had a history of excessive physical activity before her symptoms developed. Physical examination revealed 2+ pitting edema in both lower legs. She complained of mild pain in both knee joints and feet, with no tenderness or heating sensations. Laboratory results were unremarkable except for severe eosinophilia. Parasite infection, venous thrombosis, and cardiac and renal problems were excluded. A magnetic resonance imaging study of both lower extremities revealed increased signal intensity in the subcutaneous lesions, consistent w...
Source: Allergy, Asthma and Immunology Research - November 16, 2014 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Brain injury due to anaphylactic shock: broadening manifestations of Kounis syndrome
This article is protected by copyright. All rights reserved.
Source: International Endodontic Journal - June 20, 2013 Category: Dentistry Authors: G. D. Soufras, G. N. Kounis, N. G. Kounis Tags: Mini Review Source Type: research