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An educational program for trainees in serving underserved primary immunodeficiency patients
Despite increasing awareness of barriers to healthcare, disparity of care in primary immune deficiency is a reality. Many of the clinical imperatives are larger in scope: political advocacy for newborn screening programs, establishing more centers of excellence in hematopoietic stem cell transplantation in impoverished areas, and combating systemic injustice. However, achieving these objectives depends on training a new generation of committed clinical immunologists.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Jessica Galant-Swafford, Elizabeth George, Anna Meyer Source Type: research
MMF-Driven Disruption of B-cell Populations as a Biomarker for Infection Risk in Solid-Organ Transplant Recipients
We seek to identify biomarkers to predict infection risk and discover causes of infection susceptibility in pediatric kidney and liver solid-organ recipients receiving immunosuppression to prevent graft rejection.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Christine Anterasian, Lauren Loop, Cathleen Collins, Jessica Kitsen, Anoushka Tambay, Kimberly Newton, Elizabeth Ingulli, Bob Geng Source Type: research
Late Survival after Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease in a Single-Center Cohort
Chronic granulomatous disease (CGD) is an inborn error of immunity associated with significant morbidity and mortality for which hematopoietic stem cell transplant (HSCT) is a definitive treatment. In a large single-center cohort, we examined the late survival (survival at 5 years post-HSCT) of all patients who underwent HSCT for CGD at the Children ’s Hospital of Philadelphia (CHOP).
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Whitney Reid, Anne Wohlschlaeger, Brittany Adduce, Nancy Bunin, Jennifer Heimall Source Type: research
Is your kid actin out? A series of six patients with inherited ARPC1B deficiency and review of the literature
CONCLUSION: ARPC1B deficiency has a variable and heterogeneous clinical spectrum, expanded by these cases to include keloid scars and Epstein-Barr virus chronic hepatitis. A novel deletion in exon 8 is shared by three unrelated families and might be the result of a founder effect.PMID:36708766 | DOI:10.1016/j.jaip.2022.12.045
Source: Clinical Lung Cancer - January 28, 2023 Category: Cancer & Oncology Authors: Estefan ía Vásquez-Echeverri Marco Antonio Yamazaki-Nakashimada Edna Venegas Montoya Selma Cecilia Scheffler Mendoza Lina Maria Castano-Jaramillo Edgar Alejandro Medina-Torres Maria Edith Gonz ález-Serrano Melissa Espinosa-Navarro Juan Carlos Bustamant Source Type: research
Steroid induced secondary immune deficiency
Ann Allergy Asthma Immunol. 2023 Jan 18:S1081-1206(23)00011-X. doi: 10.1016/j.anai.2023.01.010. Online ahead of print.ABSTRACTDespite their widespread clinical use, oral corticosteroids (OCSs) are well known to be associated with a myriad of adverse effects, including immunosuppression. By inhibiting transcription factors and affecting leukocyte function, prolonged OCS use leads to significant CD4 lymphopenia, and also often leads to a decrease in serum IgG. Conversely, OCS use has minimal impact on circulating B cell, serum IgM, or serum IgA levels. Although there is a paucity of literature, individuals treated with prolo...
Source: Annals of Allergy, Asthma and Immunology - January 21, 2023 Category: Allergy & Immunology Authors: S Shahzad Mustafa Source Type: research
Chimeric antigen receptor (CAR)-based therapies beyond cancer
This article is protected by copyright. All rights reserved.PMID:36649259 | DOI:10.1002/eji.202250184
Source: European Journal of Immunology - January 17, 2023 Category: Allergy & Immunology Authors: Mar ía Velasco-de Andrés Guillermo Mu ñoz-Sánchez Laura Carrillo-Serradell Mar ía Del Mar Gutiérrez-Hernández Cristina Catal à Marcos Isamat Francisco Lozano Source Type: research
Gastrointestinal and Hepatic Manifestations of Chronic Granulomatous Disease
J Allergy Clin Immunol Pract. 2023 Jan 13:S2213-2198(23)00050-8. doi: 10.1016/j.jaip.2022.12.039. Online ahead of print.ABSTRACTChronic granulomatous disease (CGD) is a rare inborn error of immunity, resulting from a defect in nicotinamide adenine dinucleotide phosphate (NADPH) oxidation and decreased production of phagocyte reactive oxygen species. The main clinical manifestations are recurrent infections and chronic inflammatory disorders. Current approaches to management include antimicrobial prophylaxis and control of inflammatory complications. Hematopoietic stem cell transplantation (HSCT) or gene therapy can provide...
Source: Cancer Control - January 16, 2023 Category: Cancer & Oncology Authors: Alexander H Yang Brigit Sullivan Christa S Zerbe Suk See De Ravin Andrew M Blakely Martha M Quezado Beatriz E Marciano Jamie Marko Alexander Ling David E Kleiner John I Gallin Harry L Malech Steven M Holland Theo Heller Source Type: research
Specific Clinical and Immunological Changes Following Mesenchymal Stem Cell Transplantation in COVID-19-induced Acute Respiratory Distress Syndrome Patients: A Phase-I Clinical Trial
This study evaluated the safety and efficacy of three times transplantation of umbilical cord-derived MSCs (UC-MSCs) in terms of specific immunological and clinical changes in mild-to-moderate COVID-19-induced ARDS patients. In this single-center, open-label, phase 1 clinical trial, 20 patients diagnosed with COVID-19 and mild-to-moderate ARDS were included and were divided into two groups: a control group receiving standard care and an intervention group receiving UC-MSC in addition to standard care. Three consecutive intravenous transplants of UC-MSC (1× cells/kg body weight per each transplant) were performed in the in...
Source: Iranian Journal of Allergy, Asthma and Immunology - January 14, 2023 Category: Allergy & Immunology Authors: Najmeh Kaffash Farkhad Alireza Sedaghat Hamidreza Reihani Amir Adhami Moghadam Ahmad Bagheri Moghadam Nayereh Khadem Ghaebi Mohammad Ali Khodadoust Amin Reza Nikpoor Jalil Tavakol Afshari Source Type: research
