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Total 1303 results found since Jan 2013.

Faecal microbiota transplantation for treatment of chronic urticaria with recurrent abdominal pain and food allergy
Singapore Med J. 2023 Apr 6. doi: 10.4103/singaporemedj.SMJ-2021-423. Online ahead of print.NO ABSTRACTPMID:37077050 | DOI:10.4103/singaporemedj.SMJ-2021-423
Source: Singapore Medical Journal - April 20, 2023 Category: General Medicine Authors: Li-Quan Wu Qing-Fen Yuan Zhi-Chu Qin Yuan-Dong Xu Lan Li Jia-Ting Xu Xing-Xiang He Wen-Rui Xie Li-Hao Wu Source Type: research

Reversal of SLE and hemophagocytic lymphohistiocytosis caused by lysinuric protein intolerance through allogeneic hematopoietic stem cell transplantation
Lysinuric protein intolerance (LPI; Online Mendelian Inheritance in Man [OMIM] identifier 222700) is a rare autosomal recessive metabolic disorder caused by mutations in the SLC7A7 gene, which encodes for y+L cationic amino acid (including arginine, ornithine, and lysine) transporter-1 (y+LAT-1) protein.1 The malfunction of y+LAT-1 in polarized cells impairs the intestinal absorption and renal tubular reabsorption of cationic amino acid, resulting in malnutrition and failure to thrive.2 LPI is also classified as an inborn error of immunity owing to the immune dysregulation caused by malfunction of the y+LAT-1 protein, the ...
Source: Journal of Allergy and Clinical Immunology - March 29, 2023 Category: Allergy & Immunology Authors: Yu Zhou, Lan He, Zhongxun Yu, Meiying Quan, Hongmei Song, Chunfu Li Tags: Correspondence Source Type: research

Two cases of transplant-acquired food allergy who developed resensitization after a negative oral food challenge
Cases of food allergy after hematopoietic stem cell and solid organ transplantation in previously nonallergic transplant recipients were reported as transplant-acquired food allergy (TAFA), but information abo...
Source: Allergy, Asthma and Clinical Immunology - March 22, 2023 Category: Allergy & Immunology Authors: Akiko Nakaoka, Takayasu Nomura, Kazuyoshi Ozeki, Tomotaka Suzuki, Shigeru Kusumoto, Shinsuke Iida and Shinji Saitoh Tags: Case report Source Type: research

Autoimmune manifestations in VEXAS: Opportunities for integration and pitfalls to interpretation
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) is a novel entity manifesting with a multiplicity of clinical features. Somatic mutations of the UBA1 gene in hematopoietic stem cells constitute the genetic basis of VEXAS. As an X-linked disorder, most cases occur in men, classically developing symptoms during the fifth to sixth decade of life. Considering its multidisciplinary nature involving numerous branches of internal medicine, VEXAS has elicited a wide medical interest and several medical conditions have been associated with this disease.
Source: Journal of Allergy and Clinical Immunology - March 20, 2023 Category: Allergy & Immunology Authors: Alessandro Bruno, Carmelo Gurnari, Tobias Alexander, John A. Snowden, Raffaella Greco, Autoimmune Diseases Working Party of the European Society for Blood and Marrow Transplantation Source Type: research

The Adaptation Model of Immunity: Signal IV Matters Most in Determining the Functional Outcomes of Immune Responses
J Immunol. 2023 Mar 1;210(5):521-530. doi: 10.4049/jimmunol.2200672.ABSTRACTCurrent research in immunology and immunotherapy is fully influenced by the self-nonself model of immunity. This theoretical model suggests that alloreactivity results in graft rejection, whereas tolerance toward self-antigens expressed by malignant cells facilitates cancer development. Similarly, breakage of immunological tolerance toward self-antigens results in autoimmune diseases. Accordingly, immune suppression is recommended for the management of autoimmune diseases, allergy, and organ transplantation, whereas immune inducers are used for the...
Source: Journal of Immunology - March 7, 2023 Category: Allergy & Immunology Authors: Masoud H Manjili Source Type: research

Idiopathic Pulmonary Fibrosis and Progressive Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF), a common interstitial lung disease (ILD), is a chronic, progressive fibrosing interstitial pneumonia, with an unknown cause. IPF has been linked to several genetic and environmental risk factors. Disease progression is common and associated with worse outcomes. Management often encompasses pharmacotherapy, supportive interventions, addressing comorbidities when present, and treating hypoxia with ambulatory O2. Consideration for antifibrotic therapy and lung transplantation evaluation should occur early. Patients with ILD other than IPF, and who have radiological evidence of pulmonary fi...
Source: Immunology and Allergy Clinics of North America - March 3, 2023 Category: Allergy & Immunology Authors: Rachel Strykowski, Ayodeji Adegunsoye Source Type: research

Gene therapy for SCID, now up to 3!
Since 2000, gene therapy has become an option to treat severe combined immunodeficiency (SCID), a rare but lethal condition characterized by fully defective T lymphocyte differentiation caused by pathogenic variants in least 18 genes. The current treatment by allogeneic hematopoietic stem cell transplantation (HSCT) is effective but carries the risk of graft-versus-host disease. This treatment is based on ex  vivo gene transfer by using retroviral vector (initially gammaretrovirus, now lentivirus) to transduce the patient bone marrow CD34 cells.
Source: Journal of Allergy and Clinical Immunology - February 22, 2023 Category: Allergy & Immunology Authors: Alain Fischer, B énédicte Neven Tags: Editorial Source Type: research

IEDB ‐3D 2.0: Structural data analysis within the Immune Epitope Database
This article is protected by copyright. All rights reserved.
Source: Protein Science - February 21, 2023 Category: Biochemistry Authors: Marcus Mendes, Jarjapu Mahita, Nina Blazeska, Jason Greenbaum, Brendan Ha, Kelly Wheeler, Jiyao Wang, Deborah Shackelford, Alessandro Sette, Bjoern Peters Tags: TOOLS FOR PROTEIN SCIENCE Source Type: research

The mast cell: A Janus in kidney transplants
Mast cells (MCs) are innate immune cells with a versatile set of functionalities, enabling them to orchestrate immune responses in various ways. Aside from their known role in allergy, they also partake in both allograft tolerance and rejection through interaction with regulatory T cells, effector T cells, B cells and degranulation of cytokines and other mediators. MC mediators have both pro- and anti-inflammatory actions, but overall lean towards pro-fibrotic pathways. Paradoxically, they are also seen as having potential protective effects in tissue remodeling post-injury. This manuscript elaborates on current knowledge ...
Source: Frontiers in Immunology - February 20, 2023 Category: Allergy & Immunology Source Type: research

The Evolving Landscape of Fecal Microbial Transplantation
AbstractThe human gastrointestinal tract houses an enormous microbial ecosystem. Recent studies have shown that the gut microbiota plays significant physiological roles and maintains immune homeostasis in the human body. Dysbiosis, an imbalanced gut microbiome, can be associated with various disease states, as observed in infectious diseases, inflammatory diseases, autoimmune diseases, and cancer. Modulation of the gut microbiome has become a therapeutic target in treating these disorders. Fecal microbiota transplantation (FMT) from a healthy donor restores the normal gut microbiota homeostasis in the diseased host. Ample ...
Source: Clinical Reviews in Allergy and Immunology - February 9, 2023 Category: Allergy & Immunology Source Type: research