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Total 1303 results found since Jan 2013.
Risk Factors for Recalcitrant Chronic Rhinosinusitis in Non-Solid and Solid Transplant Recipients
CONCLUSION: Risk of ESS was greater in the solid transplant recipients compared to those who received non-solid organ transplant.PMID:37262001 | DOI:10.1177/19458924231177855
Source: American Journal of Rhinology and Allergy - June 1, 2023 Category: ENT & OMF Authors: Estephania Candelo Ashley Darakjian Karol Avila-Castano Angela Donaldson Source Type: research
Hereditary angioedema with an acute attack resolved after bone marrow transplantation for acute myeloid leukemia: a case report
Hereditary angioedema (HAE), which is caused by C1-inhibitor (C1-INH) deficiency or dysfunction, is a rare and potentially life-threatening disease. In patients with HAE, excess production of bradykinin causes...
Source: Allergy, Asthma and Clinical Immunology - May 16, 2023 Category: Allergy & Immunology Authors: Daisuke Honda, Isao Ohsawa, Masashi Aizawa, Yasuhiko Tomino and Katsuhiko Asanuma Tags: Case report Source Type: research
The role of PD-1 signaling in health and immune-related diseases
Programmed cell death 1 receptor (PD-1) and its ligands constitute an inhibitory pathway to mediate the mechanism of immune tolerance and provide immune homeostasis. Significantly, the binding partners of PD-1 and its associated ligands are diverse, which facilitates immunosuppression in cooperation with other immune checkpoint proteins. Accumulating evidence has demonstrated the important immunosuppressive role of the PD-1 axis in the tumor microenvironment and in autoimmune diseases. In addition, PD-1 blockades have been approved to treat various cancers, including solid tumors and hematological malignancies. Here, we pr...
Source: Frontiers in Immunology - May 16, 2023 Category: Allergy & Immunology Source Type: research
Immunosuppressive Polymeric Nanoparticles Targeting Dendritic Cells Alleviate Lupus Disease in < em > Fcgr2b < /em > < sup > -/- < /sup > Mice by Mediating Antigen-Specific Immune Tolerance
This study developed a new nanoparticle (NP) containing a biodegradable PDMAEMA-PLGA copolymer for target-oriented delivery to DCs in situ. PDMAEMA-PLGA NPs provided sustained drug release and exhibited immunosuppressive activity in FLT3L and GM-CSF-derived bone marrow in conventional DCs (BM-cDCs). PDMAEMA-PLGA NPs improved dexamethasone capability to convert wild-type and Fcgr2b-/- BM-cDCs from an immunogenic to tolerogenic state, and BM-cDCs treated with dexamethasone-incorporated PDMAEMA-PLGA NPs (Dex-NPs) efficiently mediated regulatory T cell (Treg) expansion in vitro. Dex-NP therapy potentially alleviated lupus dise...
Source: Cell Research - May 13, 2023 Category: Cytology Authors: Phuriwat Khiewkamrop Chamraj Kaewraemruaen Chonnavee Manipuntee Chalathan Saengruengrit Numpon Insin Asada Leelahavanichkul Warerat Kaewduangduen Opor Sonpoung Kasirapat Ariya-Anandech Nattiya Hirankarn Patcharee Ritprajak Source Type: research
Microbiota transplant to control inflammation in a patient with NLRC4 gain-of-function –induced disease
The NOD-like receptor NLR CARD-domain containing protein 4 (NLRC4) is the core component of the NLRC4-inflammasome, which plays a major role in responses to enteric pathogens, particularly, gram-negative bacteria. Gain-of-function (GOF) mutations in NLRC4 are associated with an autoinflammatory syndrome characterized by fever, early-onset enterocolitis, a nd recurrent hemophagocytic lymphohistiocytosis (HLH).1,2 NLRC4-GOF mutations cause abnormal constitutive activation of the NLRC4 inflammasome with markedly increased IL-18 production.
Source: Journal of Allergy and Clinical Immunology - May 10, 2023 Category: Allergy & Immunology Authors: Claudia Bracaglia, Giulia Marucci, Federica Del Chierico, Alessandra Russo, Manuela Pardeo, Denise Pires Marafon, Andrea Quagliariello, Ivan Caiello, Francesca Rea, Sarka Fingerhutova, Antonella Insalaco, Giusi Prencipe, Pavla Dolezalova, Fabrizio De Bene Tags: Correspondence Source Type: research
Decreased Regulatory B Cells in Pediatric Patients with Asthma
Emerging research has focused on the role of regulatory B cells (B regs) in allergic asthma.1 –3 B regs are involved in immunomodulation and have been demonstrated to suppress inflammatory responses in autoimmunity, allergy, infection, transplantation, and cancer.2 B regs secrete IL-10, an anti-inflammatory cytokine, that is theorized to have a beneficial effect on asthma pathophysiology b y suppressing the IgE-mediated allergic cascade and decreasing airway inflammation.4 In murine models, a deficiency of B regs has been associated with elevated serum IgE, eosinophilia, and increased type 2 cytokines in bronchoalveoloar lavage fluid.
Source: Annals of Allergy, Asthma and Immunology - April 24, 2023 Category: Allergy & Immunology Authors: William J. Sheehan, Naseem Maghzian, Deepa Rastogi, Catherine M. Bollard, Adora A. Lin Tags: Letters Source Type: research
Faecal microbiota transplantation for treatment of chronic urticaria with recurrent abdominal pain and food allergy
Singapore Med J. 2023 Apr 6. doi: 10.4103/singaporemedj.SMJ-2021-423. Online ahead of print.NO ABSTRACTPMID:37077050 | DOI:10.4103/singaporemedj.SMJ-2021-423
Source: Singapore Medical Journal - April 20, 2023 Category: General Medicine Authors: Li-Quan Wu Qing-Fen Yuan Zhi-Chu Qin Yuan-Dong Xu Lan Li Jia-Ting Xu Xing-Xiang He Wen-Rui Xie Li-Hao Wu Source Type: research
