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Procedure: Liver Transplant

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Total 226 results found since Jan 2013.

New Therapies for Primary Biliary Cirrhosis
Abstract Primary biliary cirrhosis (PBC) is a rare inflammatory liver disease for which ursodeoxycholic acid (UDCA) is the only therapy approved by the U.S. Food and Drug Administration. Patients with a biochemical response to UDCA therapy have a similar survival rate compared to the general population. However, up to 40 % of PBC patients do not achieve a complete response to UDCA, have an increased risk of liver-related death and liver transplantation, and represent a persistent medical need for new therapies. Several novel drugs have recently been studied and show potential efficacy in PBC. Obeticholic acid, a ...
Source: Clinical Reviews in Allergy and Immunology - October 21, 2014 Category: Allergy & Immunology Source Type: research

Ex vivo assessment of cellular immune function – applications in patient care and clinical studies
Abstract Cellular ex vivo assays have a broad range of applications in patient care and clinical studies, especially when they are standardized and highly sensitive. As compared to analyses by molecular genetics such as the single nucleotide polymorphism (SNP) testing, they are usually more global. These assays partly mimic the in vivo situation, relying on a complex interaction of various immune cells. For example, they can be used to determine modulation of alloresponses by treatment or underlying disease, diagnose and quantify primary and secondary cellular immunodeficiency, follow‐up vaccination responses, measure ad...
Source: Tissue Antigens - October 20, 2014 Category: Allergy & Immunology Authors: M. Lindemann Tags: Review article Source Type: research

Gene Replacement Therapy for Genetic Hepatocellular Jaundice
Abstract Jaundice results from the systemic accumulation of bilirubin, the final product of the catabolism of haem. Inherited liver disorders of bilirubin metabolism and transport can result in reduced hepatic uptake, conjugation or biliary secretion of bilirubin. In patients with Rotor syndrome, bilirubin (re)uptake is impaired due to the deficiency of two basolateral/sinusoidal hepatocellular membrane proteins, organic anion-transporting polypeptide 1B1 (OATP1B1) and OATP1B3. Dubin-Johnson syndrome is caused by a defect in the ATP-dependent canalicular transporter, multidrug resistance-associated protein 2 (MRP2...
Source: Clinical Reviews in Allergy and Immunology - October 16, 2014 Category: Allergy & Immunology Source Type: research

Acquired IgE-mediated food allergy after liver transplantation in children.
CONCLUSION: The risk of developing IgE-mediated food allergies is approximately three times higher within the first year after transplantation than in subsequent years. PMID: 25201761 [PubMed - as supplied by publisher]
Source: Allergologia et Immunopathologia - September 5, 2014 Category: Allergy & Immunology Authors: Catal F, Topal E, Selimoglu MA, Karabiber H, Baskıran A, Senbaba E, Varol I, Yılmaz S Tags: Allergol Immunopathol (Madr) Source Type: research

Changes in pathological and biochemical findings of systemic tissue sites in familial amyloid polyneuropathy more than 10 years after liver transplantation
Conclusions FAP may shift to systemic WT TTR amyloid formation after LT, which seems to be similar to the process in SSA. The truncation of TTR in amyloid deposits may depend on some genetic or environmental factors other than undergoing LT.
Source: Journal of Neurology, Neurosurgery and Psychiatry - June 10, 2014 Category: Neurosurgery Authors: Oshima, T., Kawahara, S., Ueda, M., Kawakami, Y., Tanaka, R., Okazaki, T., Misumi, Y., Obayashi, K., Yamashita, T., Ohya, Y., Ihse, E., Shinriki, S., Tasaki, M., Jono, H., Asonuma, K., Inomata, Y., Westermark, P., Ando, Y. Tags: Genetics, Immunology (including allergy), Neuromuscular disease, Peripheral nerve disease Source Type: research

Transfer of Peanut IgE Sensitization after Combined Pancreas‐Kidney Transplant
This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - June 1, 2014 Category: Allergy & Immunology Authors: Alalia Berry, Jeffrey Campsen, Fuad Shihab, Rafael Firszt Tags: Opinion or Debate Source Type: research

Combination of N-(3׳,4׳-dimethoxycinnamoyl) anthranilic acid with cyclosporin A treatment preserves immunosuppressive effect and reduces the side effect of cyclosporin A in rat.
In this study, we used the dark agouti (DA)-Lewis rat orthotopic liver transplantation (OLT) model to investigate whether the combination of 3,4-DAA with CsA is a promising and useful strategy to lower CsA dosage for reducing CsA side effect and preserve therapeutic effect of CsA. Here, we document that the combination treatment effectively inhibits acute liver rejection in OLT model with only half the normally suggested dosage of CsA that has much less side effect in rats than that of the full dosage. These results indicate that 3,4-DAA may serve as an effective adjunct for a CsA-based immunosuppressive regimen to treat t...
Source: European Journal of Pharmacology - February 11, 2014 Category: Drugs & Pharmacology Authors: Yong-Gang X, Ming-Zhe W, Jin-Yan Z, Zhi-Hai P, Jun-Ming X Tags: Eur J Pharmacol Source Type: research

Life-saving transplant results in end to peanut allergy
Not only can bone marrow transplants be life-saving for children with acute lymphocytic leukemia, they may also cure peanut allergies. According to research presented during the American College of Allergy, Asthma and Immunology's (ACAAI) Annual Scientific Meeting, a 10-year-old boy no longer had a peanut allergy after undergoing a bone marrow transplant. "It has been reported that bone marrow and liver transplants can transfer peanut allergy from donor to recipient," said allergist Yong Luo, MD, Ph.D., ACAAI member and lead study author...
Source: Health News from Medical News Today - November 12, 2013 Category: Consumer Health News Tags: Allergy Source Type: news

Paediatric autoimmune liver disease
Autoimmune liver disorders in childhood include autoimmune hepatitis (AIH) and AIH/sclerosing cholangitis overlap syndrome (henceforth referred to as autoimmune sclerosing cholangitis, ASC). These inflammatory liver disorders are characterised histologically by interface hepatitis, biochemically by elevated transaminase levels, and serologically by autoantibodies and increased levels of immunoglobulin G. AIH is particularly aggressive in children and progresses rapidly unless immunosuppressive treatment is started promptly. With appropriate treatment, 80% of patients achieve remission and long-term survival. For non-respon...
Source: Archives of Disease in Childhood - November 12, 2013 Category: Pediatrics Authors: Mieli-Vergani, G., Vergani, D. Tags: Liver disease, Pancreas and biliary tract, Immunology (including allergy), Hepatitis and other GI infections, Child health, Artificial and donated transplantation Review Source Type: research

Fever and confusion in a returning soldier
A 36–year–old army engineer returned from a 6–week deployment in Afghanistan. He had complained of upper respiratory tract infection even before his travel. On return he was found to be increasingly sleepy and later developed unsteadiness, slurred speech and confusion. His initial blood tests were normal, with CSF and MRI suggesting signs of encephalitis. He continued to deteriorate, requiring intubation and ventilation. Several bacterial, viral, protozoal and fungal tests were negative. He developed pancytopenia requiring frequent packed red cell and platelet transfusions. Spleen was found to be marginal...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Chandratheva, A., Singh, A. R., Sturman, S., Chaganti, S., Jacob, S. Tags: Immunology (including allergy), HIV/AIDS, Tropical medicine (infectious diseases), Drugs: CNS (not psychiatric), Epilepsy and seizures, Infection (neurology), Memory disorders (psychiatry) Association of British Neurologists (ABN) joint meeting with the Source Type: research

Weight loss, encephalopathy, urinary difficulties and numb feet in a nigerian man
We described the first case of the TTR Leu12Pro mutation in 1999. To date it has been only described in a total of 3 patients, all European. Here we describe the first report of the TTR Leu12Pro variant in an African patient.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: McColgan, P., Viegas, S., Gandhi, S., Sheikh, F., Pinney, J., Fontana, M., Rowczenio, D., Shah, S., Jaumuktane, Z., Holton, J., Schott, J., Werring, D., Hawkins, P., Reilly, M. Tags: Genetics, Immunology (including allergy), Epilepsy and seizures, Headache (including migraine), Pain (neurology), Sexual and gender disorders, Radiology, Surgical diagnostic tests, Radiology (diagnostics) Association of British Neurologists (ABN) joint Source Type: research

Successful cure of C1q deficiency in human subjects treated with hematopoietic stem cell transplantation
Hematopoietic stem cell transplantation (HSCT) is used to cure a number of primary immunodeficiency diseases but has never been attempted for patients with complement deficiencies because most complement factors are produced in the liver rather than the bone marrow. Inherited deficiency of the C1q component of the classical complement pathway is a severe autosomal recessive immunodeficiency disease associated with a high risk of death from either fulminant bacterial infections or systemic lupus erythematosus–like autoimmunity. Indeed, C1q deficiency is the strongest disease susceptibility gene for the development of seve...
Source: Journal of Allergy and Clinical Immunology - September 16, 2013 Category: Allergy & Immunology Authors: Peter D. Arkwright, Philip Riley, Stephen M. Hughes, Hana Alachkar, Robert F. Wynn Tags: Letters to the Editor Source Type: research

Development of a robust protocol for gene expression analysis using formalin-fixed, paraffin-embedded liver transplant biopsy specimens
This study was designed to compare gene transcription between resting and stressed biliary cells in culture, these cells after fixation and embedding and archival liver transplant biopsy tissue. The transcription of p21/WAF1 and transforming growth factor (TGF)-β1 showed similar changes in the fresh and embedded liver cells. However, the expression of TGF-β2 was markedly different between the fresh and embedded samples, suggesting that fixation can produce sequence-specific artefacts. Sufficient quantities of pure RNA were recovered from all the liver transplant biopsies to allow complementary DNA production. Mea...
Source: Journal of Clinical Pathology - August 16, 2013 Category: Pathology Authors: Thompson, E., Burt, A. D., Barker, C. E., Kirby, J. A., Brain, J. G. Tags: Open access, Molecular genetics, Immunology (including allergy), Clinical diagnostic tests Short report Source Type: research

Post-transplant lymphoproliferative disorders in liver transplant recipients: a clinicopathological study
Conclusions Despite its relative rarity as a complication for liver transplantation, PTLD imposes significant effects on the morbidity, mortality and treatment implications in postliver transplant patients. The clinicopathological data would hopefully provide better insight into the surveillance and management for susceptible patients.
Source: Journal of Clinical Pathology - April 21, 2013 Category: Pathology Authors: Lo, R. C.-l., Chan, S.-c., Chan, K.-l., Chiang, A. K.-s., Lo, C.-m., Ng, I. O.-l. Tags: Immunology (including allergy) Original article Source Type: research

Long‐term follow‐up of de novo allergy in pediatric liver transplantation – 10 yr experience of a single center
Abstract We conducted a study to clarify the incidence, clinical course, and risk factors of de novo allergies after liver transplantation. Ninety‐three patients who had been followed longer than one yr and who had no previous allergy history were included. Forty‐two patients (45.2%) developed de novo allergy. Of them, food allergy developed in 35 (37.6%). Respiratory allergy was observed in three (3.2%), and a patient (1.1%) had drug allergy. Fifty‐two (55.9%) of the 93 patients developed eosinophilia. The median age of patients with de novo allergy was 15 months (IR 11.3–20 months). De novo allergy developed fi...
Source: Pediatric Transplantation - February 1, 2013 Category: Transplant Surgery Authors: Yoon Lee, Yoo Min Lee, Mi Jin Kim, Suk Koo Lee, Yon Ho Choe Tags: Original Article Source Type: research