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Total 203 results found since Jan 2013.

Management of connective tissue diseases associated interstitial lung disease: a review of the published literature
Purpose of review: Interstitial lung disease (ILD), though a common and often a severe manifestation of many connective tissue diseases (CTD), is challenging to manage because of its variable presentation and the relative lack of guidelines to assist the clinician. In this review, we discuss the approach to diagnosis, treatment, and monitoring patients with CTD-associated ILD, with a focus on systemic sclerosis (SSc), rheumatoid arthritis (RA), and idiopathic inflammatory myopathy (IIM). Recent findings: High-resolution computed tomography scan and pulmonary function testing can be reliably used to diagnose ILD and monito...
Source: Current Opinion in Rheumatology - April 1, 2016 Category: Rheumatology Tags: CLINICAL THERAPEUTICS: Edited by W. Joseph McCune Source Type: research

PET/CT scan revealing active idiopathic inflammatory myopathy with normal serum sarcoplasmic enzymes levels.
Authors: Piga M, Pesella F, Corraine ML, Floris A, Cauli A, Mathieu A Abstract ****************************************************************************. PMID: 26968020 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - March 13, 2016 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The Systemic Effect of Burn Injury and Trauma on Muscle and Bone Mass and Composition
Conclusions: Burn injury significantly decreases muscle volume and density. Increased muscle atrophy using our computed tomographic morphometric analysis correlated with a significant increase in intramuscular inflammatory markers and proteolysis enzymes. This study demonstrates a unique characterization of how burn injuries may worsen local myopathy. Moreover, it provides a novel approach for quantifying muscle atrophy over an expanded period.
Source: Plastic and Reconstructive Surgery - October 30, 2015 Category: Cosmetic Surgery Tags: Experimental: Original Articles Source Type: research

Pneumothorax in a dog caused by necrotizing pneumonia secondary to heatstroke
Abstract ObjectiveTo describe the clinical course, diagnostic findings, medical and surgical treatments, and outcome in a dog with spontaneous pneumothorax secondary to necrotizing pneumonia thought to be a delayed complication of heatstroke. Case SummaryA 1.5‐year‐old Labrador Retriever developed spontaneous pneumothorax 12 days after an episode of exertional heat stroke. Computed tomography was performed and showed bilateral pneumothorax and multifocal pulmonary consolidation, especially at the lung periphery. A median sternotomy was performed, and multifocal, well‐demarcated areas of consolidated pulmonary tissue ...
Source: Journal of Veterinary Emergency and Critical Care - October 1, 2015 Category: Veterinary Research Authors: Jocelyn B. Garber, Katrin Saile, Nathalie Rademacher, James R. Wignall, Leslie D. McLaughlin, Kirk A. Ryan Tags: Case Report Source Type: research

Medial humeral epicondylitis in clinically affected cats
ConclusionsCats with forelimb lameness should be evaluated for MHE. This condition is associated with free joint bodies and neurogenic myopathy. Surgical treatment is associated with excellent outcome in the majority of cats.
Source: Veterinary Surgery - August 1, 2015 Category: Veterinary Research Authors: Ronny Streubel, Thomas Bilzer, Paula Grest, Daniel Damur, Pierre M. Montavon Tags: Original Clinical Article Source Type: research

Use of dual-energy computed tomography for the evaluation of calcinosis in patients with systemic sclerosis
We examined the usefulness of dual-energy computed tomography (DECT) in the evaluation of symptomatic systemic sclerosis (SSc)-related calcinosis of the hands. We performed DECT scan of the hands in 16 patients with symptomatic SSc-calcinosis to better characterize the calcinosis, their locations within the soft tissues, and exclude monosodium urate (MSU) crystal deposition. We also compared their computed tomography (CT) images to plain radiographs of one hand. Pertinent clinical information from this cohort was collected. Sixteen SSc patients underwent DECT and plain X-ray imaging of the hands. Five of the 16 SSc patient...
Source: Clinical Rheumatology - July 3, 2015 Category: Rheumatology Source Type: research

Dermatomyositis in a Patient with Cholangiocarcinoma Detected by an 18F-Fluorodeoxyglucose ...
We report a 66-year-old woman with metastatic cholangiocarcinoma, initially presented with bilateral proximal muscle uptake on PET-CT without clinical muscle symptoms. The initial interpretation of the high muscle uptake was metastasis to the muscles. However, while awaiting for chemotherapy, muscle weakness evolved and rapidly progressed. The level of creatine phosphokinase was significantly elevated. Electromyography revealed moderate myopathy, and a muscle biopsy showed degenerating myofibers with variable sizes. The diagnosis of paraneoplastic dermatomyositis was made. This case highlights that, although rare, paraneop...
Source: Cancer Research and Treatment - March 17, 2015 Category: Cancer & Oncology Tags: Case Report Source Type: research

Clinicopathological features of sarcoidosis manifesting as generalized chronic myopathy
Abstract Although chronic myopathy has been reported to affect skeletal muscle in sarcoidosis, its clinicopathological features have not been fully elucidated. We characterized the clinical, histopathological, and prognostic features of eleven patients with sarcoidosis manifesting with chronically progressive, generalized myopathy that was confirmed with muscle biopsy. Generalized muscle weakness extending to the four extremities and trunk was the cardinal feature of these cases. Muscle atrophy was evident in nine patients, particularly in the lower limbs, whereas myalgia was reported in only two patients. Myopath...
Source: Journal of Neurology - February 26, 2015 Category: Neurology Source Type: research

"Mechanic's hands" during antisynthetase syndrome: A marker of systemic involvement?
CONCLUSION: Mechanic's hands may be considered a marker of visceral involvement and should be sought in any instance of suspected antisynthetase syndrome flare-up. PMID: 25620556 [PubMed - as supplied by publisher]
Source: Annales de Dermatologie et de Cenereologie - January 22, 2015 Category: Dermatology Authors: Nahas O, Haddad F, Maalouly G Tags: Ann Dermatol Venereol Source Type: research

Lung squamous carcinoma with two paraneoplastic syndromes: dermatomyositis and Lambert–Eaton myasthenic syndrome
ConclusionRecognition of paraneoplastic syndrome is crucial for early diagnosis of lung cancer because up to 80% of patients may present paraneoplastic syndromes before any other direct indication of malignancy. Early diagnosis and treatment of paraneoplastic syndrome is also important because delayed diagnosis may result in rapid disease progression and irreversible neurological damage.
Source: The Clinical Respiratory Journal - November 26, 2014 Category: Respiratory Medicine Authors: Yuanrong Dai, Ping Li, Sunshun Yan, Xiaodong Xia, Zhixiong Li, Mengling Xia Tags: Case Report Source Type: research

Lung squamous carcinoma with two paraneoplastic syndromes: dermatomyositis and Lambert –Eaton myasthenic syndrome
ConclusionRecognition of paraneoplastic syndrome is crucial for early diagnosis of lung cancer because up to 80% of patients may present paraneoplastic syndromes before any other direct indication of malignancy. Early diagnosis and treatment of paraneoplastic syndrome is also important because delayed diagnosis may result in rapid disease progression and irreversible neurological damage.
Source: The Clinical Respiratory Journal - November 25, 2014 Category: Respiratory Medicine Authors: Yuanrong Dai, Ping Li, Sunshun Yan, Xiaodong Xia, Zhixiong Li, Mengling Xia Tags: CASE REPORT Source Type: research

Lung squamous carcinoma with two paraneoplastic syndromes ‐Dermatomyositis and Lambert‐Eaton myasthenic syndrome
We reported a case of a 60‐year‐old male smoker who presented multiple erythematous lesion for six months with progressive proximal muscular weakness, and developed to dysphonia in two months. His chest computed tomography showed a spiculate pulmonary nodule near the hilar in the right upper lobe and mediastinal lymph nodes enlargement. Lung biopsy showed squamous cell carcinoma. The patients’blood test revealed elevated creatine kinase levels. Electromyography results was consistent with moderate myopathy accompanied with a pattern suggestive of Lambert‐Eaton myasthenic syndrome. So we made the diagnosis of an ove...
Source: The Clinical Respiratory Journal - October 21, 2014 Category: Respiratory Medicine Authors: Yuanrong Dai, Ping Li, Sunshun Yan, Xiaodong Xia, Zhixiong Li, Mengling Xia Tags: Other Source Type: research

G.P.267: Nebulin-associated myopathy: New genetic and pathologic presentations
This study represents the disease associated with novel NEB mutations marked by the presence of additional pathological features, as well as nemaline rods. Although mixed pathology has been already reported in core-rod myopathy with NEB mutations, muscle pathology in these patients is more characteristic, and clinical manifestation is much milder compared with the previous ones. This report suggests the expanded clinical and pathological spectrum of nebulin-associated myopathy with new genetic and pathologic features. Further, next genome sequencing might be helpful for searching mutations in big, huge-sized genes, such as NEB.
Source: Neuromuscular Disorders - September 4, 2014 Category: Neurology Authors: Y.E. Park, S.H. Park, J.M. Lee, J.H. Shin, B.R. Kang, C.H. Lee, D.S. Kim Source Type: research

Successful open abdomen treatment for multiple ischemic duodenal perforated ulcers in dermatomyositis
Conclusions: In patients with dermatomyositis, when clinical findings and symptoms suggest abdominal vasculitis, it is very important to be aware of the risk of bowel and particularly duodenal perforations. Open abdomen treatment favors control of contamination by gastrointestinal contents, offers temporary abdominal closure, helps ICU care and delays definitive surgery.
Source: World Journal of Emergency Surgery - August 30, 2014 Category: Emergency Medicine Authors: Roberta VillaStefano CostaSibilla FocchiCarlo CorbelliniMassimo VigorelliEttore Contessini Avesani Source Type: research