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Specialty: Respiratory Medicine

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Total 170 results found since Jan 2013.

Interstitial lung disease with statin-associated necrotizing autoimmune myopathy responding to rituximab.
PMID: 26744248 [PubMed - as supplied by publisher]
Source: Archivos de Bronconeumologia - December 29, 2015 Category: Respiratory Medicine Authors: Meira Dias O, Guedes Baldi B, Nathan Costa A, Katsuyuki Shinjo S, Miossi R, Adib Kairalla R Tags: Arch Bronconeumol Source Type: research

Effect of mobilization in critically ill patientes about peripheral muscle strength
Conclusion: The results suggest that a Standardized Mobilization Protocol improves peripheral muscle strength in critically ill patients.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Lima, A. M. S., Barros, C. E. S. R., Vilaca, A. F., Correia, R. F., Goncalves, T. F., Silva, R. M. O., Cardozo, S. M., Rattes, C. F. S., Souza, H. C. M., Brandao, D. C., Dornelas, A. F. A., Campos, S. L. Tags: 2.1 Acute Critical Care Source Type: research

Effect of enzyme replacement therapy (ERT) added to Home Mechanical Ventilation (HMV) in Adult Pompe disease
We present two cases where addition of ERT to Home Mechanical Ventilation (HMV) showed improvements in lung function and gas exchange that may not be entirely attributable to nocturnal HMV and therefore may further indicate the beneficial role of ERT in conjunction with HMV in Adult Pompe disease. We present two cases where addition of ERT to Home Mechanical Ventilation (HMV) showed improvements in lung function and gas exchange that may not be entirely attributable to nocturnal HMV and therefore may further indicate the beneficial role of ERT in conjunction with HMV in Adult Pompe disease.
Source: Respirology Case Reports - September 1, 2015 Category: Respiratory Medicine Authors: Nadia Sayeed, Pooja Sharma, Manahil Abdelhalim, Rahul Mukherjee Tags: Case Report Source Type: research

Corticosteroids in the Critically Ill Patient: Benefits and Risks for Hospital-acquired Pneumonia/Ventilator-associated Pneumonia
Corticosteroids are among the most commonly prescribed medications. Because of their wide use and vast influence on various aspects of homeostasis, it is not surprising that steroids may be beneficial in some clinical scenarios and deleterious in others. The interplay between nosocomial pneumonias and steroids represents one of the most remarkable intersections between a drug and a disease. Corticosteroids may influence the risk of a hospitalized patient developing pneumonia, but they may ultimately be necessary if a patient develops catecholamine-resistant septic shock or if overt bronchospasm is present. In addition, pro...
Source: Clinical Pulmonary Medicine - August 31, 2015 Category: Respiratory Medicine Tags: Critical Care/Respiratory Care Source Type: research

Glutaric aciduria type 2 presenting with acute respiratory failure in an adult.
We present a case of a 19-year old female with progressive muscle weakness was admitted in intensive care unit (ICU) with respiratory failure and acute renal failure. Patient was unconscious. Pupils were anisocoric and light reflex was absent. She had hepatomegaly. The laboratory results showed a glucose level of 70 mg/dl and the liver enzymes were high. The patient also had hyponatremia (117 mEq/L) and lactate level of 3.9 mmol/L. Tandem MS and organic acid analysis were compatible with GTA type II. Carnitine 1gr, riboflavin 100 mg and co-enzymeQ10 100 mg was arranged. After four months from beginning of treatment ta...
Source: Respiratory Care - August 5, 2015 Category: Respiratory Medicine Authors: Ersoy EO, Rama D, Ünal Ö, Sivri S, Topeli A Tags: Respir Med Case Rep Source Type: research

Nocturnal respiratory failure in a child with congenital myopathy – management using average volume‐assured pressure support (AVAPS)
Abstract This is a case report of the effective use of bi‐level positive airway pressure support (BPAP) using the volume‐assured pressure support feature in a pediatric patient with a congenital myopathy and significant nocturnal hypoventilation. Our patient was started on nocturnal nasal mask BPAP but required high pressures to improve her oxygen saturations and CO2 baseline. She was then trialed on a BPAP machine with the volume‐assured pressure support feature on. The ability of this machine to adjust inspiratory pressures to give a targeted tidal volume allowed the patient to be on lower pressure settings for per...
Source: Respirology Case Reports - June 1, 2015 Category: Respiratory Medicine Authors: Natalie Gentin, Bruce Williamson, Ganesh Thambipillay, Arthur Teng Tags: Case Report Source Type: research

Glutaric Aciduria Type 2 Presenting With Acute Respiratory Failure In An Adult
We present a case of a 19-year old female with progressive muscle weakness was admitted in intensive care unit(ICU) with respiratory failure and acute renal failure. Patient was unconscious. Pupils were anisocoric and light reflex was absent. She had hepatomegaly. The laboratory results showed a glucose level of 70 mg/dl and the liver enzymes were high. The patient also had hyponatremia (117 mEq/L) and lactate level of 3.9 mmol/L.Tandem MS and organic acid analysis were compatible with GTA type II. Carnitine 1gr, riboflavin 100 mg and co-enzymeQ10 100 mg was arranged. After four months from beginning of treatment tandem MS...
Source: Respiratory Medicine Case Reports - May 12, 2015 Category: Respiratory Medicine Source Type: research

Lung MRI and impairment of diaphragmatic function in Pompe disease
Background: Pompe disease is a progressive metabolic myopathy. Involvement of respiratory muscles leads to progressive pulmonary dysfunction, particularly in supine position. Diaphragmatic weakness is considered to be the most important component. Standard spirometry is to some extent indicative but provides too little insight into diaphragmatic dynamics. We used lung MRI to study diaphragmatic and chest-wall movements in Pompe disease. Methods: In ten adult Pompe patients and six volunteers, we acquired two static spirometer-controlled MRI scans during maximum inspiration and expiration. Images were manually segmented. Af...
Source: BMC Pulmonary Medicine - May 6, 2015 Category: Respiratory Medicine Authors: Stephan WensPierluigi CietAdria Perez-RoviraKarla LogieElizabeth SalamonPiotr WielopolskiMarleen de BruijneMichelle KruijshaarHarm TiddensPieter van DoornAns van der Ploeg Source Type: research

INDACO project: COPD and link between comorbidities, lung function and inhalation therapy
Conclusions Our study showed a high prevalence of comorbidities in COPD, with some differences related to gender. Number of comorbidities and airflow obstruction represent the determinant of inhalation therapy prescription. Dyspnoea and acute exacerbation of COPD, unlikely suggested by guidelines, are not significant drivers of therapy in the real life setting of our study.
Source: Multidisciplinary Respiratory Medicine - January 27, 2015 Category: Respiratory Medicine Source Type: research

Template-operated quantitative motor unit potential analysis in diaphragm of patients with myotonic dystrophy
The diaphragm is the main inspiratory muscle. Template-operated quantitative motor unit potential (MUP) analysis (qEMG) has been shown to be useful in the diagnosis of myopathy in limb muscles. Diaphragmatic MUPs in a healthy population are much smaller than in limb muscles and due to the waxing and waning respiratory EMG pattern, MUP sampling is difficult.The aim of our study was to evaluate feasibility and utility of the quantitative MUP analysis in the diagnosis of myopathy of the diaphragm.qEMG of the diaphragm and the biceps brachii muscles, phrenic nerve conduction studies and respiratory function tests were performe...
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Leonardis, L., Podnar, S. Tags: 4.1 Clinical Respiratory Physiology, Exercise and Functional Imaging Source Type: research

The effect of pulmonary rehabilitation in patients with chronic respiratory failure other than COPD
Conclusion:Pulmonary rehabilitation improves quality of life and physical capacity in patients with chronic respiratory failure other than COPD.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Silva, G., Morano, M. T., Araujo, A., Bitar, N., Viana, C., Mont'alverne, D., Mesquita, R., Pereira, E. Tags: 1.2 Rehabilitation and Chronic Care Source Type: research

Early introduction of non invasive ventilation (NIV) in patients with systemic lupus erythematosus (SLE) and diaphragmatic weakness
Conclusion; SLE related diaphragmatic myopathy seems to have a reversible component and needs to be aggressively managed. NIV is effective in managing ventilatory impairment in shrinking lungs. Respiratory and rheumatology pathway needs to be developed with a low threshold in investigating and managing lupus patients with early signs of respiratory impairment.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Ansari, Z., Sharma, P., Herath, S., Lang, M., Mohamed, A., Nathani, N. Tags: 2.2 Noninvasive Ventilatory Support Source Type: research

Cardiopulmonary exercise testing (CPET) in patients with unexplained dyspnoea
Conclusionin patients with dyspnoea but no diagnosis from standard investigations CPET provides important additional information. A limited number of variables provide diagnostic data.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Griffiths, O., Anindo, B. Tags: 4.1 Clinical Respiratory Physiology, Exercise and Functional Imaging Source Type: research

A deadly web
An 18-year-old patient with metabolic myopathy due to long-chain fatty acid coenzyme A dehydrogenase-deficiency1 2 presented with worsening positional dyspnoea. He had required invasive ventilation via tracheostomy 6 months earlier. Examination revealed respiratory distress, a prolonged inspiratory phase and abdominal paradox. Non-invasive ventilation improved dyspnoea but surprisingly high inspiratory pressures were required. CT imaging revealed subtle, sublaryngeal irregularity. Volumetric reconstruction identified a thin tracheal web (figure 1). Diathermy via rigid bronchoscopy (figure 2) immediately improved venti...
Source: Thorax - December 15, 2014 Category: Respiratory Medicine Authors: Nanzer, A. M., Jordan, S., Padley, S., Griffiths, M., Hind, M. Tags: Images in Thorax, Journalology, Muscle disease, Neuromuscular disease, Physiotherapy, Adult intensive care, Sports and exercise medicine, Cardiothoracic surgery, Ethics Chest clinic Source Type: research

Lung squamous carcinoma with two paraneoplastic syndromes: dermatomyositis and Lambert–Eaton myasthenic syndrome
ConclusionRecognition of paraneoplastic syndrome is crucial for early diagnosis of lung cancer because up to 80% of patients may present paraneoplastic syndromes before any other direct indication of malignancy. Early diagnosis and treatment of paraneoplastic syndrome is also important because delayed diagnosis may result in rapid disease progression and irreversible neurological damage.
Source: The Clinical Respiratory Journal - November 26, 2014 Category: Respiratory Medicine Authors: Yuanrong Dai, Ping Li, Sunshun Yan, Xiaodong Xia, Zhixiong Li, Mengling Xia Tags: Case Report Source Type: research