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Specialty: Allergy & Immunology

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Total 1296 results found since Jan 2013.

Circ_0072008, an oncogene in pancreatic ductal adenocarcinoma, contributes to tumour cell malignant progression and glycolysis by regulating miR-545-3p/SLC7A11 axis
CONCLUSION: Circ_0072088 elicited oncogenic role in malignant cell progression and glycolysis of PDAC cells through circ_0072088/miR-545-3p/SLC7A11 pathway.HighlightsCirc_0072088 was upregulated in PDAC tumours and was associated with high tumour burden.Blocking circ_0072088 suppressed cell proliferation, migration, invasion, and glycolysis in PDAC cells.Circ_0072088 could directly regulate miR-545-3p, and SLC7A11 was a target of miR-545-3p.Restoring miR-545-3p mimicked the effects of circ_0072088 knockdown in PDAC cell in vitro.PMID:35166634 | DOI:10.1080/08916934.2022.2027919
Source: Autoimmunity - February 15, 2022 Category: Allergy & Immunology Authors: Hui Sun Fang Liu Hongqing Zhang Source Type: research

Stress level of glucocorticoid exacerbates neuronal damage and A β production through activating NLRP1 inflammasome in primary cultured hippocampal neurons of APP-PS1 mice
In this study, we investigated the effects of chronic GC exposure on NOX2-NLRP1 inflammasome activation and the protective effects of NLRP1-siRNA against GC-induced neuronal injury in primary hippocampal neurons of APP/PS1 mice. The results showed that chronic dexamethasone (DEX, 1 µM) exposure 72 h had no significant effect on the primary hippocampal neurons of WT mice, but significantly increased Aβ1-42 accumulation (2.17 ± 0.19 fold in APP group and 3.06 ± 0.49 fold in APP + DEX group over WT group) and neuronal injury in primary hippocampal neurons of APP/PS1 mice. Meanwhile, chronic DEX exposure significantly incr...
Source: International Immunopharmacology - July 1, 2022 Category: Allergy & Immunology Authors: Liu Yang Huimin Zhou Lei Huang Yong Su Liangliang Kong Pengmin Ji Ran Sun Chao Wang Weiping Li Weizu Li Source Type: research

Properdin produced by dendritic cells contributes to the activation of T cells
Immunobiology. 2022 Jul 9;227(4):152246. doi: 10.1016/j.imbio.2022.152246. Online ahead of print.ABSTRACTThe complement system does not only play an important role in the defence against microorganism and pathogens, but also contributes to the regulation of innate and adaptive immunity. Especially activation fragments C3a and C5a and complement activation at the interface of antigen presenting cell (APC) and T cell, were shown to have a role in T cell activation and proliferation. Whereas most complement factors are produced by the liver, properdin, a positive regulator of the C3 convertase, is mainly produced by myeloid c...
Source: Immunobiology - July 17, 2022 Category: Allergy & Immunology Authors: Mieke F van Essen Nicole Schlagwein Dani ëlle J van Gijlswijk-Janssen Jurjen M Ruben Cees van Kooten COMBAT consortium Source Type: research

Lnc-AIFM2-1 promotes HBV immune escape by acting as a ceRNA for miR-330-3p to regulate CD244 expression
Chronic hepatitis B (CHB) virus infection is a major risk factor for cirrhosis and hepatocellular carcinoma (HCC). Hepatitis B virus (HBV) immune escape is regulated by the exhaustion of virus-specific CD8+ T cells, which is associated with abnormal expression of negative regulatory molecule CD244. However, the underlying mechanisms are unclear. To investigate the important roles of non-coding RNAs play in CD244 regulating HBV immune escape, we performed microarray analysis to determine the differential expression profiles of long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and mRNAs in patients with CHB and patients wi...
Source: Frontiers in Immunology - February 9, 2023 Category: Allergy & Immunology Source Type: research

HBSP improves kidney ischemia-reperfusion injury and promotes repair in properdin deficient mice via enhancing phagocytosis of tubular epithelial cells
Phagocytosis plays vital roles in injury and repair, while its regulation by properdin and innate repair receptor, a heterodimer receptor of erythropoietin receptor (EPOR)/β common receptor (βcR), in renal ischaemia-reperfusion (IR) remains unclear. Properdin, a pattern recognition molecule, facilitates phagocytosis by opsonizing damaged cells. Our previous study showed that the phagocytic function of tubular epithelial cells isolated from properdin knockout (PKO) mouse kidneys was compromised, with upregulated EPOR in IR kidneys that was further raised by PKO at repair phase. Here, helix B surface peptide (HBSP), derive...
Source: Frontiers in Immunology - May 3, 2023 Category: Allergy & Immunology Source Type: research

Exosomal circRNA-001264 promotes AML immunosuppression through induction of M2-like macrophages and PD-L1 overexpression
Int Immunopharmacol. 2023 Aug 30;124(Pt A):110868. doi: 10.1016/j.intimp.2023.110868. Online ahead of print.ABSTRACTExosomes can help to effectively regulate the crosstalk between cancer cells and normal cells in the tumor microenvironment. They also regulate cancer cell proliferation and apoptosis by virtue of their cargo molecules. Transmission electron microscopy (TEM) together with differential ultracentrifugation served for verifying the presence of exosomes. In vivo and in vitro assays served for determining the role of exosomal circ_001264. RNA pull-down and dual-luciferase reporter assays assisted in the classifica...
Source: International Immunopharmacology - September 1, 2023 Category: Allergy & Immunology Authors: Ashuai Du Qinglong Yang Xiaoying Sun Qiangqiang Zhao Source Type: research

IL‐17 induces expression of vascular cell adhesion molecule through signaling pathway of NF‐κB, but not Akt1 and TAK1 in vascular smooth muscle cells
In this study, we reported that IL‐17 induced expression of VCAM‐1 in SMCs is dependent on NF‐κB, but independent of Akt1 and TAK1. This is because knocking down Akt1 or TAK1 by siRNA did not reduce IL‐17‐induced activation of NF‐κB and expression of VCAM‐1, whereas knocking down NF‐κB by siRNA markedly inhibited IL‐17‐mediated upregulation of VCAM‐1 expression. In addition, IL‐17‐induced expression of VCAM‐1 is partially dependent on activation of ERK1/2. Therefore, these signaling pathways of IL‐17‐mediated upregulation of VCAM‐1 expression might be therapeutic targets for treatment o...
Source: Scandinavian Journal of Immunology - February 19, 2013 Category: Allergy & Immunology Authors: Haitao Zhang, Jing Chen, Xiaoming Liu, Lena Awar, Anthony McMickle, Fengwu Bai, Shanmugam Nagarajan, Shiguang Yu Tags: Experimental Immunology Source Type: research

IL‐17 Induces Expression of Vascular Cell Adhesion Molecule Through Signalling Pathway of NF‐κB, but not Akt1 and TAK1 in Vascular Smooth Muscle Cells
In this study, we reported that IL‐17‐induced expression of VCAM‐1 in SMCs is dependent on NF‐κB, but independent of Akt1 and TAK1. This is because knocking down Akt1 or TAK1 by siRNA did not reduce IL‐17‐induced activation of NF‐κB and expression of VCAM‐1, whereas knocking down NF‐κB by siRNA markedly inhibited IL‐17‐mediated upregulation of VCAM‐1 expression. In addition, IL‐17‐induced expression of VCAM‐1 is partially dependent on activation of ERK1/2. Therefore, these signalling pathways of IL‐17‐mediated upregulation of VCAM‐1 expression might be therapeutic targets for treatmen...
Source: Scandinavian Journal of Immunology - March 26, 2013 Category: Allergy & Immunology Authors: H. Zhang, J. Chen, X. Liu, L. Awar, A. McMickle, F. Bai, S. Nagarajan, S. Yu Tags: Experimental Immunology Source Type: research

B cell activating factor-dependent expression of vascular endothelial growth factor in MH7A human synoviocytes stimulated with tumor necrosis factor-α
Abstract Angiogenesis in rheumatoid arthritis (RA) is one of the histological hallmarks, which is mediated by expression of vascular endothelial growth factor (VEGF) in RA synovium. VEGF expression is enhanced by TNF-α, the main pro-inflammatory cytokine in RA. B cell activating factor (BAFF) which plays a role in maturation and maintenance of B cells is also associated with autoimmune RA. Here, we investigated whether BAFF could regulate VEGF expression in TNF-α-stimulated synovium using MH7A synovial cells that are established by transfection with the SV40 T antigen. Changes in hBAFF and hVEGF were measured by...
Source: International Immunopharmacology - May 14, 2013 Category: Allergy & Immunology Authors: Lee GH, Lee J, Lee JW, Choi WS, Moon EY Tags: Int Immunopharmacol Source Type: research

TRPV1 inhibition attenuates IL-13 mediated asthma features in mice by reducing airway epithelial injury.
Abstract Even though neurogenic axis is well known in asthma pathogenesis much attention had not been given on this aspect. Recent studies have reported the importance of TRP channels, calcium-permeable ion channels and key molecules in neurogenic axis, in asthma therapeutics. The role of TRPV1 channels has been underestimated in chronic respiratory diseases as TRPV1 knockout mice of C57BL/6 strains did not attenuate the features of these diseases. However, this could be due to strain differences in the distribution of airway capsaicin receptors. Here, we show that TRPV1 inhibition attenuates IL-13 induced asthma ...
Source: International Immunopharmacology - March 1, 2013 Category: Allergy & Immunology Authors: Rehman R, Bhat YA, Panda L, Mabalirajan U Tags: Int Immunopharmacol Source Type: research

The role of intracellular high-mobility group box 1 in the early activation of Kupffer cells and the development of Con A-induced acute liver failure.
Abstract Acute liver failure (ALF) is a highly complex syndrome characterized by devastating activation of early activation of Kupffer cells (KCs) has been implicated in the pathogenesis of ALF. However, the factors regulating KC early activation are virtually unexplored. The aim of present study was to determine the role of the intracellular high-mobility group box 1 (HMGB1) in modulating the early activation of KCs during ALF. The intravenous injection of Concanavalin A (Con A) was used to establish a mouse model of ALF. The dynamic pro-inflammatory properties and MHC II expression of KCs were measured by qRT-PC...
Source: Immunobiology - April 27, 2013 Category: Allergy & Immunology Authors: Yang Q, Liu Y, Shi Y, Zheng M, He J, Chen Z Tags: Immunobiology Source Type: research

PSORS1C1 May Be Involved in Rheumatoid Arthritis.
This study investigated whether PSORS1C1/CDSN was involved in RA. The TagSNPs rs3130983, rs3778638 and rs4959053 in the PSORS1C1/CDSN locus were shown to predict susceptibility to RA in two independent RA cohorts using a TaqMan genotyping assay and Sequenom MassARRAY. The expression of PSORS1C1/CDSN was determined with western blotting and ELISA. Cultured synovial fibroblasts from RA patients (RASF) were treated with anti-PSORS1C1 siRNA. The TaqMan genotyping assay demonstrated significant differences in the rs3130983 and rs4959053 allele frequencies (p=0.002001 and 1.74E-07, respectively) and genotype frequencies (0.01050...
Source: Immunology Letters - June 13, 2013 Category: Allergy & Immunology Authors: Sun H, Xia Y, Wang L, Wang Y, Chang X Tags: Immunol Lett Source Type: research