IL‐17 induces expression of vascular cell adhesion molecule through signaling pathway of NF‐κB, but not Akt1 and TAK1 in vascular smooth muscle cells

In this study, we reported that IL‐17 induced expression of VCAM‐1 in SMCs is dependent on NF‐κB, but independent of Akt1 and TAK1. This is because knocking down Akt1 or TAK1 by siRNA did not reduce IL‐17‐induced activation of NF‐κB and expression of VCAM‐1, whereas knocking down NF‐κB by siRNA markedly inhibited IL‐17‐mediated upregulation of VCAM‐1 expression. In addition, IL‐17‐induced expression of VCAM‐1 is partially dependent on activation of ERK1/2. Therefore, these signaling pathways of IL‐17‐mediated upregulation of VCAM‐1 expression might be therapeutic targets for treatment of IL‐17‐mediated inflammation.

Source: Scandinavian Journal of Immunology - February 19, 2013 Category: Allergy & Immunology Authors: Haitao Zhang, Jing Chen, Xiaoming Liu, Lena Awar, Anthony McMickle, Fengwu Bai, Shanmugam Nagarajan, Shiguang Yu Tags: Experimental Immunology Source Type: research