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Specialty: Drugs & Pharmacology
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Total 2046 results found since Jan 2013.
Network pharmacology-based analysis of the mechanism of < em > Saposhnikovia divaricata < /em > for the treatment of type I allergy
CONCLUSION: Saposhnikovia divaricata could inhibit IgE-induced degranulation of mast cells, providing a scientific basis for further research and clinical applications of SD in TIA treatment.PMID:35760567 | DOI:10.1080/13880209.2022.2086583
Source: Pharmaceutical Biology - June 27, 2022 Category: Drugs & Pharmacology Authors: Xiangsheng Li Hui Li Tingting Wang Yang Zhao Yuxin Shao Yizhao Sun Yanfen Zhang Zhongcheng Liu Source Type: research
Hymenoptera Venom Allergy And Anaphylaxis
Curr Pharm Des. 2022 Aug 17. doi: 10.2174/1381612828666220817091039. Online ahead of print.ABSTRACTHymenoptera stings can induce allergic and occasionally fatal reactions, and are responsible for significant morbidity and deterioration in health-related quality of life. The diagnostic work-up must consider the medical history of patients, in the context of venom allergy epidemiology and hymenoptera taxonomy, and the clinical manifestations of the reactions, to channel the available in vivo and in vitro tests towards the most accurate diagnosis and the consequent appropriate management, also considering the risk profile of ...
Source: Current Pharmaceutical Design - August 18, 2022 Category: Drugs & Pharmacology Authors: M Beatrice Bil ò Giovanna Danieli Gianluca Moroncini Matteo Martini Source Type: research
Targeting eosinophils in allergy, inflammation and beyond
Nature Reviews Drug Discovery 12, 117 (2013).
doi:10.1038/nrd3838
Authors: Patricia C. Fulkerson & Marc E. Rothenberg
Eosinophils can regulate local immune and inflammatory responses, and their accumulation in the blood and tissue is associated with several inflammatory and infectious diseases. Thus, therapies that target eosinophils may help control diverse diseases, including atopic disorders such as asthma and allergy, as well as
Source: Nature Reviews Drug Discovery - January 21, 2013 Category: Drugs & Pharmacology Authors: Patricia C. FulkersonMarc E. Rothenberg Tags: Review Source Type: research
Iowa pharmacists fill allergy testing niche.
PMID: 24830990 [PubMed - in process]
Source: American Journal of Health-System Pharmacy : AJHP - May 18, 2014 Category: Drugs & Pharmacology Authors: Traynor K Tags: Am J Health Syst Pharm Source Type: research
Flushing and pruritus secondary to prescription fish oil ingestion in a patient with allergy to fish
Conclusion Due to the patient’s allergic history, timing of onset/offset of the reaction, laboratory evidence, and the use of the Naranjo probability scale, prescription fish oil capsules were deemed the probable cause of this patient’s pruritus and flushing of the face and trunk. Practitioners and patients should always ensure they have an updated list of allergies within the patient’s medical record that includes medications as well as foods and food additives.
Source: International Journal of Clinical Pharmacy - October 16, 2014 Category: Drugs & Pharmacology Source Type: research
Novel Targeted Therapies for Eosinophil-Associated Diseases and Allergy.
Abstract
Eosinophil-associated diseases often present with life-threatening manifestations and/or chronic organ damage. Currently available therapeutic options are limited to a few drugs that often have to be prescribed on a lifelong basis to keep eosinophil counts under control. In the past 10 years, treatment options and outcomes in patients with clonal eosinophilic and other eosinophilic disorders have improved substantially. Several new targeted therapies have emerged, addressing different aspects of eosinophil expansion and inflammation. In this review, we discuss available and currently tested agents as well...
Source: Annual Review of Pharmacology and Toxicology - October 17, 2014 Category: Drugs & Pharmacology Authors: Radonjic-Hoesli S, Valent P, Klion AD, Wechsler ME, Simon HU Tags: Annu Rev Pharmacol Toxicol Source Type: research
Food allergy drugs step up to Phase III
Nature Reviews Drug Discovery 15, 149 (2016).
doi:10.1038/nrd.2016.24
Author: Katie Kingwell
Two biotechs have carved out a regulatory pathway for what could become the first FDA-approved preventative peanut allergy therapies.
Source: Nature Reviews Drug Discovery - March 2, 2016 Category: Drugs & Pharmacology Authors: Katie Kingwell Tags: News and Analysis Source Type: research
Health-Related Quality of Life During Routine Treatment with the SQ-Standardised Grass Allergy Immunotherapy Tablet: A Non-Interventional Observational Study
Conclusions
Routine treatment with the SQ® grass SLIT-tablet resulted in clear improvements in disease-specific and general quality of life, while no improvements were observed in patients treated only symptomatically.
Source: Clinical Drug Investigation - March 15, 2016 Category: Drugs & Pharmacology Source Type: research
Optimization of clinical decision support through minimization of excessive drug allergy alerts.
PMID: 27045062 [PubMed - in process]
Source: American Journal of Health-System Pharmacy : AJHP - April 7, 2016 Category: Drugs & Pharmacology Authors: Brodowy B, Nguyen D Tags: Am J Health Syst Pharm Source Type: research
FDA Approves Flonase Sensimist Allergy Relief
WARREN, N.J. 2 August 2016 -- GSK Consumer Healthcare announced today that the U.S. Food and Drug Administration (FDA) has approved Flonase ® Sensimist™ Allergy Relief (fluticasone furoate, 27.5 mcg spray) as an over-the-counter (OTC) treatment...
Source: Drugs.com - New Drug Approvals - August 2, 2016 Category: Drugs & Pharmacology Source Type: news
Standardized quality house dust mite sublingual tablets (Acarizax ® ): a guide to their use as sublingual allergy immunotherapy in Europe
AbstractStandardized quality (SQ) house dust mite (HDM) allergen extract tablets (Acarizax®) are a valuable option for sublingual allergy immunotherapy (SLIT) in adults with confirmed HDM-induced allergic rhinitis or allergic asthma. In placebo-controlled natural-field and environmental exposure challenge chamber trials, Acarizax® reduced the symptoms of allergic rhinitis in adults with HDM-induced allergic rhinitis ( ± asthma) and reduced the risk of asthma exacerbations in adults with HDM-induced allergic asthma. A systemic antibody response to HDM allergens has been observed within 4 weeks of initiating SLIT with A...
Source: Drugs and Therapy Perspectives - September 18, 2016 Category: Drugs & Pharmacology Source Type: research
In silico tools for exploring potential human allergy to proteins
Publication date: Available online 22 October 2016 Source:Drug Discovery Today: Disease Models Author(s): Maria Hayes, Pierre Rougé, Annick Barre, Corinne Herouet-Guicheney, Erwin L. Roggen Bioinformatics can help scientists to develop hypotheses about proteins that may need to be tested further for risks of causing allergy. In silico methodologies and tools like databases and comparison software, play an important role in the assessment of protein allergenicity and allergenicity mechanisms. They can identify whether a novel protein is an existing allergen and/or has the potential to cross-react with an existing allergen...
Source: Drug Discovery Today: Disease Models - October 28, 2016 Category: Drugs & Pharmacology Source Type: research
Cas9 in Genetically Modified Food Is Unlikely to Cause Food Allergy.
In this study, Cas9 and the peptides potentially encoded by Cas9 genes were studied regarding their immunogenicity, in terms of the digestibility of Cas9 and the homology of the peptides to food allergens. First, the digestibility and thermal stability of Cas9 were studied. Digestibility was tested with natural or heat-denatured Cas9 in simulated gastric fluid in vitro. The two types of Cas9 were digested rapidly. Cas9 was also gradually degraded during heat treatment. Second, the peptides potentially encoded by Cas9 genes were examined for their homology to food allergens. Specifically, an 8-mer exact match search and a s...
Source: Biological and Pharmaceutical Bulletin - November 4, 2016 Category: Drugs & Pharmacology Authors: Nakajima O, Nishimaki-Mogami T, Kondo K Tags: Biol Pharm Bull Source Type: research
