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Specialty: Drugs & Pharmacology

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Total 2046 results found since Jan 2013.

Lymphocyte Transformation Test (LTT) in Allergy to Benznidazole: A Promising Approach
We report a series of 31 patients (69% women) referred to our Allergy unit with suspected hypersensitivity to Bzn, twenty-three of them with mild reactions and nine of them with severe reactions. LTT with Bzn was performed in 31 patients and in 8 negative controls. LTT was also performed in 25 and 20 of these patients with nifurtimox and Mtn, respectively. Twenty one out of thirty one patients were Bzn prick tested, all negative. We obtained 2/21 positive results on patch tests to Bzn. LTT with Bzn was positive in 22/31 patients (Sensitivity 75.9% and specificity 100%). The test was considered positive with a stimulation i...
Source: Frontiers in Pharmacology - May 20, 2019 Category: Drugs & Pharmacology Source Type: research

State of the Art: Development of a Sublingual Allergy Immunotherapy Tablet for Allergic Rhinitis in Japan.
Abstract Allergic rhinitis (AR) caused by house dust mite (HDM) and Japanese cedar pollen (JCP) represents a significant, expanding health problem in Japan. Allergic symptoms often have a severe impact on the QOL such as sleep disturbance and reduced school and work performance. In addition to the classical symptoms, AR is known to be a risk factor for the development of allergic asthma, a potentially life-threatening condition. Allergy immunotherapy (AIT) is a well-documented, safe, effective treatment option for respiratory allergic disease. It has been demonstrated that AIT can provide relief from clinical symp...
Source: Biological and Pharmaceutical Bulletin - January 8, 2020 Category: Drugs & Pharmacology Authors: Ohashi-Doi K, Lund K, Mitobe Y, Okamiya K Tags: Biol Pharm Bull Source Type: research

Allergen immunotherapy for respiratory allergy: to what extent can the risk of systemic reactions be reduced?
Authors: Incorvaia C, Pucciarini F, Makri E, Gritti BL, Ridolo E Abstract INTRODUCTION: Allergen immunotherapy is an effective treatment for respiratory allergy, but the administration to patients of extracts of the causative allergen may elicit systemic reactions, which include, particularly with subcutaneous immunotherapy (SCIT), anaphylaxis. In the past, the occurrence (tough rare) of fatal reactions has represented a serious problem that has limited the prescription of SCIT. AREAS COVERED: The authors analyzed in this review the safety data of SCIT, especially concerning the years following the identificati...
Source: Expert Opinion on Drug Safety - June 10, 2020 Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research

How often we diagnose allergy to ranitidine?
Authors: Bocșan IC, Sabin O, Matei D, Muntean A, Buzoianu AD Abstract H2 receptors' antagonists (H2RA) are widely used drugs and they are generally well-tolerated. Ranitidine hypersensitivity reactions (HR) are rarely reported. The article emphasizes the importance of recognizing ranitidine as a cause of anaphylaxis and the advantages and limits of allergological evaluation to establish a positive diagnose. We reviewed a series of published cases of ranitidine-induced hypersensitivity reactions, starting from a clinical case presentation. Moreover, we analyzed the ranitidine related adverse events in the Eudravigi...
Source: European Review for Medical and Pharmacological Sciences - November 10, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Hypersensitivity to Vitamins with a Focus on Immediate-Type Reactions: Food or Drug Allergy?
Authors: Gianfranco C, Garvey LH, Nettis E, Casciaro F, Alsowaidi S, Foti C, Vacca A Abstract Vitamins are essential substances for normal cell functions, growth, and development. However, they cannot be produced by the human organism, so intake must be through the diet. Vitamin deficiency causes the onset of different diseases, ranging from pellagra to pernicious anemia, which can be corrected by reintroducing the missing vitamin form. To supply the right amount of vitamins to the body, every vitamin naturally occurring in foodstuff has been identified, extracted and synthetically produced, thus allowing either fo...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - December 29, 2020 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

A Safe and Novel Outpatient Subcutaneous Vitamin B12 Desensitization Protocol in A Patient with Crohn's Disease and Vitamin B12 Allergy: Case Report
CONCLUSION: This is the first subcutaneous vitamin B12 desensitization protocol reported to have been safely performed in the outpatient setting.PMID:35346003 | DOI:10.2174/1574886317666220328160026
Source: Current Drug Safety - March 29, 2022 Category: Drugs & Pharmacology Authors: Sara W Van Meerbeke Andrej A Petrov Arthur M Barrie Iii Merritt L Fajt Source Type: research

Extraction, Purification, and Development of Sublingual Film (SLIT Films) Comprising Cockroach Allergen for Treatment of Allergy
CONCLUSION: SLIT Film containing cockroach allergen from Periplaneta americana were successfully developed and evaluated. SLIT films of cockroach allergen could be more beneficial and convenient for emergency use in patients when compared to subcutaneous immunotherapy. SLIT films provide dose accuracy and are a promising alternative for SCIT and SLIT drops and tablets.PMID:35718958 | DOI:10.2174/1567201819666220617122411
Source: Current Drug Delivery - June 20, 2022 Category: Drugs & Pharmacology Authors: Leishangthem Anita Venkatesh D P Sajeev Kumar B Paranjothy Kanni Chandramouli Ramnarayanan Roopa Karki Nagendra Prasad Komarla Suresh Janadri Source Type: research