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Specialty: Drugs & Pharmacology
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Total 2046 results found since Jan 2013.
The clinical pharmacist role in patients with suspected allergy to beta-lactams: A systematic review
CONCLUSION: The pharmacist intervention in the evaluation of the patient with suspected allergy to beta-lactams is effective, safe and feasible to implement on daily clinical practice. The standardization of protocols to clarify the history of allergies and development of evaluation tools represent simple screenings to perform delabelling or refer to the Immunoallergology service, improving penicilins use and reducing the need for second line antibiotics. More studies are needed to standardize the desensitization tests made by pharmacists. However, despite these results, the involvement and leadership of the pharmacist in ...
Source: Farmacia Hospitalaria - September 11, 2023 Category: Drugs & Pharmacology Authors: Jesus Cotrina Luque Maria Jos é Rei Miriam Capoulas Cl áudia Santos Pedro Raimundo Source Type: research
GSTA1*-69C/T and GSTO2*N142D as asthma- and allergy-related risk factors in Italian adult patients.
This article is protected by copyright. All rights reserved.
PMID: 24471578 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Pharmacology and Physiology - January 28, 2014 Category: Drugs & Pharmacology Authors: Piacentini S, Polimanti R, Iorio A, Cortesi M, Papa F, Rongioletti M, Liumbruno GM, Manfellotto D, Fuciarelli M Tags: Clin Exp Pharmacol Physiol Source Type: research
Late latent syphilis in a patient with end-stage renal disease and presumptive penicillin allergy.
CONCLUSION: After the completion of an oral desensitization protocol, the standard three-dose regimen of intramuscular penicillin G for late latent syphilis was safely administered to a hemodialysis patient without dosage adjustment or repeated desensitization.
PMID: 24644115 [PubMed - in process]
Source: American Journal of Health-System Pharmacy : AJHP - March 23, 2014 Category: Drugs & Pharmacology Authors: Grice KT, Day SA Tags: Am J Health Syst Pharm Source Type: research
Pharmacologic options for the treatment and management of food allergy.
Authors: Kobernick AK, Chambliss J, Burks AW
Abstract
Food allergy affects approximately 5% of adults and 8% of children in developed countries, and there is currently no cure. Current pharmacologic management is limited to using intramuscular epinephrine or oral antihistamines in response to food allergen exposure. Recent trials have examined the efficacy and safety of subcutaneous, oral, sublingual, and epicutaneous immunotherapy, with varying levels of efficacy and safety demonstrated. Bacterial adjuvants, use of anti-IgE monoclonal antibodies, and Chinese herbal formulations represent exciting potential for dev...
Source: Expert Review of Clinical Pharmacology - February 14, 2016 Category: Drugs & Pharmacology Tags: Expert Rev Clin Pharmacol Source Type: research
Impact of an antimicrobial stewardship initiative to evaluate β-lactam allergy in patients ordered aztreonam.
CONCLUSION: An ASQI that included critical evaluation of patient-reported β-lactam allergies led to decreased aztreonam use, reduced antimicrobial expenditure, and similar clinical outcomes to those observed before implementation.
PMID: 26896530 [PubMed - as supplied by publisher]
Source: American Journal of Health-System Pharmacy : AJHP - February 22, 2016 Category: Drugs & Pharmacology Authors: Estep PM, Ferreira JA, Dupree LH, Aldridge PJ, Jankowski CA Tags: Am J Health Syst Pharm Source Type: research
Implementation of a penicillin allergy screening tool to optimize aztreonam use.
CONCLUSION: Implementation of the PAST and provider and pharmacist education reduced the use of aztreonam by promoting the first-line use of β-lactam alternatives.
PMID: 26896502 [PubMed - in process]
Source: American Journal of Health-System Pharmacy : AJHP - February 22, 2016 Category: Drugs & Pharmacology Authors: Staicu ML, Brundige ML, Ramsey A, Brown J, Yamshchikov A, Peterson DR, Baran A, Laguio-Vila M Tags: Am J Health Syst Pharm Source Type: research
Uvaol attenuates pleuritis and eosinophilic inflammation in ovalbumin-induced allergy in mice.
Abstract
Uvaol, a triterpene present in olives and virgin olive oil, has been shown to possess anti-inflammatory properties and antioxidant effects. However, until now, no studies have demonstrated its potential effects on allergic inflammation. The aim of this study was to evaluate the anti-inflammatory effects of uvaol in a mouse model of allergy characterized by eosinophil-dominant inflammation in actively sensitized mice. The anti-inflammatory effect of uvaol was analyzed in two murine models of allergic inflammation (pleurisy and asthma). In these models, Swiss mice were sensitized and challenged with ovalbum...
Source: European Journal of Pharmacology - March 29, 2016 Category: Drugs & Pharmacology Authors: Agra LC, Lins MP, da Silva Marques P, Smaniotto S, de Melo CB, Lagente V, Barreto E Tags: Eur J Pharmacol Source Type: research
Development of an Assay Method to Search for Compounds Inhibiting Stress-Enhanced Allergy.
Abstract
Stress exacerbates allergic disorders such as atopic dermatitis and asthma. It is also an important factor affecting blood flow (BF). Allergic reactions also affect blood flow. For example, we observed that mice sensitized with hen egg-white lysozyme (HEL) have decreased BF during the allergy induction phase. Based on this finding, we established a model for evaluating chronic restraint stress-enhanced allergies. Mice were sensitized with 12.5 µg/head of HEL on day 0, then restrained for 90 min daily on days 1-3, 5, and 6 in a modified 50 mL polystyrene conical centrifuge tube with multiple air hol...
Source: Biological and Pharmaceutical Bulletin - May 8, 2016 Category: Drugs & Pharmacology Authors: Oku H, Kanaya R, Ishiguro K Tags: Biol Pharm Bull Source Type: research
Dissolving Microneedles as Skin Allergy Test Device.
Abstract
The possibility of using dissolving microneedles (DMs) as a skin allergy test device was studied in rats. Poly-L-arginine was used as a model allergen. Dextran was used to prepare three kinds of DM array chips containing different doses of poly-L-arginine: 17.1±0.5 µg (low-dose DM), 42.2±0.8 µg (medium-dose DM), and 87.4±1.1 µg (high-dose DM); each 1.0 cm(2) chip contained 300 DMs. The mean lengths of the low-, medium-, and high-dose DM were 489±3, 485±3, and 492±1 µm and mean diameters of the base were 301±2, 299±1, and 299±2 µm, respectively. Furthermore, for the low-, medium-,...
Source: Biological and Pharmaceutical Bulletin - April 8, 2017 Category: Drugs & Pharmacology Authors: Ito Y, Matsumoto K, Osakama N, Yoshioka R, Kobuchi S, Sakaeda T, Takada K Tags: Biol Pharm Bull Source Type: research
OTC Fluticasone Furoate Nasal Spray (Flonase Sensimist) for Allergic Rhinitis (online only)
Date: April 24, 2017
Issue #:
1519Summary:
The nasal spray formulation of the corticosteroid
fluticasone furoate is now available over the
counter (OTC) asFlonase Sensimist Allergy Relief
(GSK) in the same strength as the prescription
product(Veramyst) for treatment of seasonal or
perennial allergic rhinitis. It is the fourth intranasal
corticosteroid to become available OTC.
Source: The Medical Letter - March 22, 2017 Category: Drugs & Pharmacology Authors: admin Tags: Allergic rhinitis Budesonide Clarispray corticosteroids Flonase Allergy Relief Flonase Sensimist fluticasone furoate Fluticasone propionate Nasacort Allergy 24HR Pediatrics Rhinocort Allergy Spray Triamcinolone acetonide Veramyst Source Type: research
A practical guide for pharmacists to successfully implement penicillin allergy skin testing.
Conclusion: PAST is rapidly becoming an effective, long-term antimicrobial stewardship tool to optimize antimicrobial prescribing in both the inpatient and outpatient settings. Pharmacists have demonstrated significant benefit as providers of PAST services in a variety of healthcare settings with a number of different healthcare professionals.
PMID: 30689753 [PubMed - in process]
Source: American Journal of Health-System Pharmacy : AJHP - January 25, 2019 Category: Drugs & Pharmacology Authors: Bland CM, Bookstaver PB, Griffith NC, Heil EL, Jones BM, Ann Justo J, Staicu ML, Torney NP, Wall GC Tags: Am J Health Syst Pharm Source Type: research
The role of antimicrobial treatment during pregnancy on the neonatal gut microbiome and the development of atopy, asthma, allergy and obesity in childhood.
Authors: Milliken S, Allen RM, Lamont RF
Abstract
INTRODUCTION: The use of antibiotics prenatally, during pregnancy, or neonatally may have adverse effects on the neonatal gut microbiome, and adversely affect the development of the infant immune system, leading to the development of childhood atopy, asthma, allergy and obesity. Areas covered: We reviewed new evidence about vaginal eubiosis and dysbiosis from molecular-based, cultivation-independent techniques, and how this affects the neonatal gut microbiome and early development of the immune system in infants. We have considered the association between maternal u...
Source: Expert Opinion on Drug Safety - February 12, 2019 Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
The Importance of Tablet Formulation on Allergen Release Kinetics and Efficiency: Comparison of Freeze-dried and Compressed Grass Pollen Sublingual Allergy Immunotherapy Tablet Formulations.
Abstract
PURPOSE: Efficient delivery of allergens to the sublingual mucosa is a prerequisite for successful sublingual immunotherapy (SLIT) for allergy, and in order to become available to immune-competent cells embedded in the sublingual mucosa, allergens need to be delivered in a soluble form. Delivery of solubilized allergens poses a particular challenge for tablet-based allergy immunotherapy, in which allergens are administered under the tongue in the form of dry tablets and need to be dissolved rapidly in a small volume of saliva, with little or no agitation. The purposes of this article were to compare the p...
Source: Clinical Therapeutics - March 14, 2019 Category: Drugs & Pharmacology Authors: Lund K, Kito H, Skydtsgaard MB, Nakazawa H, Ohashi-Doi K, Lawton S Tags: Clin Ther Source Type: research
Tailored Sublingual Immunotherapy in a Monosensitized Child with Natural Rubber Latex Allergy
Adverse reactions to natural rubber latex (NRL) represent a group of clinical manifestations that include non-allergic reactions and immediate-type or delayed-type allergic reactions. NRL sublingual immunotherapy (SLIT) has been demonstrated to be an effective and safe practice for latex clinical manifestations with good patient tolerance. A pediatric case of NRL allergy managed with an effective tailored SLIT is described. This case is compelling because the girl, who did not have an atopic background, suffered from NRL allergy with high reactivity and unique monosensitization. To the best of our knowledge, this is the fi...
Source: Pharmacology - September 7, 2020 Category: Drugs & Pharmacology Source Type: research
