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Total 104 results found since Jan 2013.

The utility and tolerability of ultrasound guided muscle biopsy in the investigation of myopathy: a follow-up study
ConclusionThis follow-up study reinforces the conclusion of its predecessor by highlighting that ultrasound guided percutaneous muscle biopsy is a useful and tolerable adjunct to the traditional surgical technique in investigating muscle disorders.
Source: Journal of Ultrasound - August 4, 2023 Category: Radiology Source Type: research

Efficacy of ultrasound elastography in detecting active myositis in children: can it replace MRI?
Conclusion Compression–strain US elastography does not accurately detect active myositis in children with juvenile idiopathic inflammatory myopathy and cannot replace MRI as the imaging standard for detecting myositis in these children. The association between abnormal US elastography and increased muscle echogenicity suggests that elastography is capable of detecting muscle derangement in patients with myositis; however further studies are required to determine the clinical significance of these findings.
Source: Pediatric Radiology - April 24, 2015 Category: Radiology Source Type: research

A novel SYNE1 variant segregates with a wrist-drop phenotype in a large multigeneration pedigree (P1.138)
Conclusions:We report a novel SYNE1-related myopathy characterized by a unique pattern of upper extremity and facial weakness. Previously, SYNE1-related muscle disease has been reported in (2) individual cases and one parent-offspring trio with proximal muscle weakness and contractures, and was designated as Emery-Dreifuss muscular dystrophy type 4. The pedigree described here is the largest reported to date and expands the phenotype associated with SYNE1 pathogenic variants.Disclosure: Dr. Roggenbuck has nothing to disclose. Dr. Patel has nothing to disclose. Dr. Hehir has nothing to disclose. Dr. Iyadurai has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Roggenbuck, J., Patel, R., Hehir, M., Iyadurai, S. Tags: Myopathies & amp;amp; Myasthenia Gravis I Source Type: research

Ultrasound-based detection of glucocorticoid-induced impairments of muscle mass and structure in Cushing ’s disease
ConclusionsWe provided preliminary evidence that the ultrasound-derived measurements of muscle thickness and echo intensity can be useful to detect and track the changes of muscle mass and structure in patients with steroid myopathy and we suggest that the combined assessment of muscle mass, strength, and performance should be systematically applied in the routine examination of steroid myopathy patients.
Source: Journal of Endocrinological Investigation - November 15, 2018 Category: Endocrinology Source Type: research

Granulomatous Myositis Associated With Acetylcholine Receptor Antibodies Without Clinical Myasthenia
We present a case of biopsy-proven granulomatous myositis associated with positive acetylcholine receptor binding, blocking, and modulating and antistriated antibodies, without clear clinical symptoms of myasthenia gravis and in the absence of thymoma. In addition, we include rarely reported neuromuscular ultrasound findings of granulomatous myositis in a patient without sarcoidosis. Inflammatory myopathy may precede development of myasthenia gravis in myasthenia gravis associated with concurrent inflammatory myopathy, and it is important to remain vigilant for symptoms suggestive of myasthenia gravis, especially in the pr...
Source: Journal of Clinical Neuromuscular Disease - August 28, 2021 Category: Neurology Tags: Short Report Source Type: research

Imaging: seeing muscle in new ways
Purpose of reviewThe idiopathic inflammatory myopathies are diseases that can be difficult to diagnose and evaluate, but diagnosis has been improved by modern imaging techniques. Advances in imaging continue to be made. Therefore, it is necessary to evaluate the implications of these advances for the diagnosis, understanding, and management of muscle diseases. Recent findingsThere have been advances in imaging across multiple modalities. Several new radiotracers show an improved ability to focus on inflammation better than older agents. Magnetic resonance spectroscopy has shown the ability to diagnose several idiopathic in...
Source: Current Opinion in Rheumatology - October 2, 2014 Category: Rheumatology Tags: MYOSITIS AND MYOPATHIES: Edited by Paul H. Plotz Source Type: research

Ultrasound in the Assessment of Myopathic Disorders
Summary: Neuromuscular ultrasound (US) augments a careful physical examination and electrodiagnostic evaluation in the evaluation of suspected myopathy. Ultrasound evaluation of muscle can identify abnormal echo intensity, size, and movement. Because it is painless and noninvasive, US can be used to evaluate multiple muscles to direct the electrodiagnostic examination or muscle biopsy. Some patterns of muscle involvement can suggest specific etiologies. Most muscular dystrophies show homogenously increased muscle echo intensity with attenuation of the US signal, likely resultant from increased intramuscular fat and fibrosi...
Source: Journal of Clinical Neurophysiology - April 1, 2016 Category: Neurology Tags: Invited Review Source Type: research

Nonsurgical hypoparathyroidism is associated with skeletal muscle dysfunction and restrictive lung disease
CONCLUSION: Detailed testing of patients with HP without overt muscle and lung diseases revealed significant impairment in parameters of skeletal muscle function. Myopathy and RLD were observed in a considerable proportion of patients with HP.PMID:37477385 | DOI:10.1093/ejendo/lvad091
Source: European Journal of Endocrinology - July 21, 2023 Category: Endocrinology Authors: Takasi Anush Babu Zia Hashim Zafar Neyaz Vinita E Mani Neeraj Jain Eesh Bhatia Anjali Mishra Saroj Kumar Sahoo Source Type: research

A Novel Method for Targeting Intramuscular Diaphragm Injections Using Ultrasound and Electromyography (P02.220)
CONCLUSIONS: This study demonstrates the feasibility and practicality of using ultrasound to guide injections and needle EMG in animal models in an effort to reduce complications associated with conventional blind technique. Further, this new method demonstrates the feasibility of targeted diaphragm injections with gene replacement therapy in muscle diseases.Supported by: MDA (Muscular Dystrophy Association); AFM (Association Francais Contre les Myopathy); Joshua Frase Foundation.Disclosure: Dr. Sarwal has nothing to disclose. Dr. Serfas has nothing to disclose. Dr. Mitchell has nothing to disclose. Dr. Cartwright has noth...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Sarwal, A., Serfas, J. D., Mitchell, E., Cartwright, M., Beggs, A., Buj-Bello, A., Childers, M. Tags: P02 Clinical Neurophysiology: EMG Source Type: research

P.13.9 Acoustic radiation force impulse imaging for the differentiation of muscle tissue stiffness in neuromuscular disorders
Acoustic Radiation Force Impulse (ARFI)-Imaging is an ultrasound-based elastography method enabling quantitative measurement of tissue stiffness. It involves the mechanical excitation of tissue using acoustic pulses to generate localized displacements resulting in shear-wave propagation, which is tracked using correlation-based methods and recorded in meters/s. The aim of this study is to evaluate the sensitivity and specificity of ARFI-imaging for muscle tissue stiffness differentiation (fat vs. fibrous tissue) in select muscles of patients unaffected by muscle disease vs. those affected by collagen 6 myopathy (COL6), LAM...
Source: Neuromuscular Disorders - September 7, 2013 Category: Neurology Authors: J. Dastgir, C. Vuillerot, K. Harrison, A. Poon, S. Donkervoort, M. Leach, M. Jain, K. Meilleur, A. Rutkowski, A. Mankodi, C. Bonnemann Source Type: research

The clinical features, diagnosis and classification of dermatomyositis.
Abstract Dermatomyositis (DM) is an idiopathic inflammatory myopathy (IIM) characterized by an inflammatory infiltrate primarily affecting the skeletal muscle and skin. Most common and peculiar cutaneous lesions include Gottron's papules, Gottron's sign and heliotrope rash. Different DM subsets have been identified until now encompassing classic DM, amyopathic DM, hypomyopathic DM, post-myopathic DM, and DM sine dermatitis. Patients with DM have a higher incidence rate of malignancy than the normal population. In these patients cancer occurs in about 30% of cases with higher occurrence in men and in elderly people...
Source: Journal of Autoimmunity - January 24, 2014 Category: Allergy & Immunology Authors: Iaccarino L, Ghirardello A, Bettio S, Zen M, Gatto M, Punzi L, Doria A Tags: J Autoimmun Source Type: research

Using the Coronary Artery Calcium Score to Guide Statin Therapy: A Cost-Effectiveness Analysis Original Articles
Conclusions— CAC testing in intermediate risk patients can be cost-effective but only if statins are costly or significantly affect quality of life.
Source: Circulation: Cardiovascular Quality and Outcomes - March 18, 2014 Category: Cardiology Authors: Pletcher, M. J., Pignone, M., Earnshaw, S., McDade, C., Phillips, K. A., Auer, R., Zablotska, L., Greenland, P. Tags: Health policy and outcome research, Primary prevention, Coronary imaging: angiography/ultrasound/Doppler/CC, Epidemiology Original Articles Source Type: research