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Total 102 results found since Jan 2013.
Light-regulated RNA interference induced by p-hydroxyphenacyl-modified siRNA in mammalian cells
This study will open new doors for optochemical regulation of a variety of genes by pHP caging group in mammalian cell culture.PMID:37700699 | DOI:10.1080/15257770.2023.2258171
Source: Nucleosides, Nucleotides and Nucleic Acids - September 13, 2023 Category: Biochemistry Authors: Swati Arora Chengde Mao Source Type: research
Cannabidiol alleviates perfluorooctane sulfonate-induced macrophage extracellular trap mediate inflammation and fibrosis in mice liver
Ecotoxicol Environ Saf. 2023 Aug 15;263:115374. doi: 10.1016/j.ecoenv.2023.115374. Online ahead of print.ABSTRACTAs a new type of persistent organic pollutant, perfluorooctane sulphonate (PFOS) has received extensive attention worldwide. Cannabidiol (CBD) is a non-psychoactive natural cannabinoid extract that has been proved to have antioxidation, regulation of inflammation and other functions. However, the effects of PFOS on liver injury and whether CBD can alleviate PFOS-induced liver injury are still unclear. Therefore, in this study, we used CBD (10 mg/kg) and/or PFOS (5 mg/kg) to intraperitoneally inject mice for 30 d...
Source: Ecotoxicology and Environmental Safety - August 17, 2023 Category: Environmental Health Authors: Dongliu Luo Jintao Zhang Hang Yin Shanshan Li Shiwen Xu Shu Li Source Type: research
Transporter and metabolic enzyme-mediated intra-enteric circulation of SN-38, an active metabolite of irinotecan: A new concept
Biochem Biophys Res Commun. 2023 Apr 28;665:19-25. doi: 10.1016/j.bbrc.2023.04.109. Online ahead of print.ABSTRACTSN-38, an active metabolite of irinotecan (CPT-11), is thought to circulate enterohepatically via organic anion-transporting polypeptides (OATPs), UDP-glucuronyl transferases (UGTs), multidrug resistance-related protein 2 (MRP2), and breast cancer resistance protein (BCRP). These transporters and enzymes are expressed in not only hepatocytes but also enterocytes. Therefore, we hypothesized that SN-38 circulates between the intestinal lumen and the enterocytes via these transporters and metabolic enzymes. To tes...
Source: Biochemical and Biophysical Research communications - May 6, 2023 Category: Biochemistry Authors: Larasati Martha Akane Nakata Shinnosuke Furuya Wangyang Liu Xieyi Zhang Kenta Mizoi Takuo Ogihara Source Type: research
A self-amplified ferroptosis nanoagent that inhibits the tumor upstream glutathione synthesis to reverse cancer chemoresistance
J Control Release. 2023 Mar 18:S0168-3659(23)00197-9. doi: 10.1016/j.jconrel.2023.03.030. Online ahead of print.ABSTRACTFerroptosis has recently become an attractive strategy to combat the chemoresistance of cancer cells, but the intracellular ferroptosis defense system greatly challenges the efficient ferroptosis induction. Herein, we report a ferrous metal-organic framework-based nanoagent (FMN) that inhibits the intracellular upstream glutathione synthesis and induces self-amplified ferroptosis of cancer cells, for reversing chemoresistance and boosting chemotherapy. The FMN is loaded with SLC7A11 siRNA (siSLC7A11) and ...
Source: Cancer Control - March 20, 2023 Category: Cancer & Oncology Authors: Chuang Yang Zheng Chen Min Wei Shen Hu Mengyuan Cai Nan Wang Yunan Guan Fangyuan Li Qiang Ding Daishun Ling Source Type: research
Metal-Organic Frameworks Nanocarriers for Functional Nucleic Acid Delivery in Biomedical Applications
Chem Rec. 2023 Mar 13:e202300018. doi: 10.1002/tcr.202300018. Online ahead of print.ABSTRACTMetal-organic frameworks (MOFs), a distinctive funtionalmaterials which is constructed by various metal ions and organic molecules, have gradually attracted researchers' attention from they were founded. In the last decade, MOFs emerge as a biomedical material with potential applications due to their unique properties. However, the MOFs performed as nanocarriers for functional nucleic acid delivery in biomedical applications rarely summarized. In this review, we introduce recent developments of MOFs for nucleic acid delivery in vari...
Source: Chemical Record - March 13, 2023 Category: Chemistry Authors: Li He Mengdi Shang Zhongkai Chen Zhaoqi Yang Source Type: research
A pH-responsive metal-organic framework for the co-delivery of HIF-2 α siRNA and curcumin for enhanced therapy of osteoarthritis
The occurrence of osteoarthritis (OA) is highly correlated with the reduction of joint lubrication performance, in which persistent excessive inflammation and irreversible destruction of cartilage dominate the...
Source: Journal of Nanobiotechnology - January 17, 2023 Category: Nanotechnology Authors: Zi-Jian Zhang, Ying-Ke Hou, Ming-Wa Chen, Xue-Zhao Yu, Si-Yu Chen, Ya-Ru Yue, Xiong-Tian Guo, Jin-Xiang Chen and Quan Zhou Tags: Research Source Type: research
