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Exposure: Staphylococcus aureus skin colonization predisposes to food allergy in the Learning Early about Allergy to Peanut (LEAP) and LEAP-On studies
Food allergies often begin early in life. Although there is no cure for food allergies, recent efforts to desensitize by using immunotherapy have shown promise in decreasing risk during accidental exposures. In a retrospective study early introduction of milk and peanut associates with reduced incidence of allergy to milk1 and peanut,2 respectively. In the prospective Learning Early about Allergy to Peanut (LEAP) and LEAP-On studies,3 introduction of peanut to 4- to 11-month-old children reduced risk of peanut allergy by age 5 years.
Source: Journal of Allergy and Clinical Immunology - June 26, 2019 Category: Allergy & Immunology Authors: Joan M. Cook-Mills, Mark H. Kaplan, Matthew J. Turner, Kirsten M. Kloepfer, Rajesh Kumar Tags: Editorial Source Type: research
Persistent cow ’s milk allergy is associated with decreased childhood growth: A longitudinal study
Food allergy is a prevalent problem, with well-described risks involving safety, comorbidities, and quality of life. An expanding body of research suggests that food allergy and elimination diets can also affect childhood growth and nutrition and that allergy to cow's milk (CM)1-4 or multiple foods5 impart particular risk. Nearly all studies to date have been cross-sectional, and the few longitudinal investigations of growth in children with food allergy have been limited to the first years of life.
Source: Journal of Allergy and Clinical Immunology - November 5, 2019 Category: Allergy & Immunology Authors: Karen A. Robbins, Robert A. Wood, Corinne A. Keet Tags: Letter to the Editor Source Type: research
Treatment with High Temperature Processed Foods “Baked Protocol” In Patients with IgE Mediated Cow's Milk Allergy and Egg Allergy
Most cases of food allergy to cow milk and egg evolve to tolerance. For more persistent cases, studies show that the introduction of high temperature processed foods (Baked) could help tolerance and improve quality of life. Objective: Evaluate efficacy and adverse events after Baked protocol in patients with cow milk protein allergy (CMPA) and egg allergy (EA).
Source: Journal of Allergy and Clinical Immunology - January 31, 2020 Category: Allergy & Immunology Authors: Giovanna Lucy Cortez Aliaga, Pablo Torres, Patricia Salles-Cunha, Fabio Morato De Castro, Ariana Yang Source Type: research
Single-Center Noninferiority Randomized Trial on the Efficacy and Safety of Low- and High-Dose Rush Oral Milk Immunotherapy for Severe Milk Allergy
Conclusions: An equally increased dose effect was observed for maintenance OIT doses of 20 and 100 mL in children with severe milk allergy. The risk of severe symptoms in the maintenance phase was lower in the low-dose group. A low-dose OIT regimen is recommended for severe milk allergy.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - June 22, 2020 Category: Allergy & Immunology Source Type: research
Alteration of Allergen Fold of Bos d 5 into a Hypoallergenic Vaccine for Immunotherapy of Cow ’s Milk Allergy
Conclusion: Thus, we developed a new strategy, which was based on rational molecular reassembly for allergen-specific immunotherapy (AIT) of CMA and food allergy.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - August 12, 2021 Category: Allergy & Immunology Source Type: research
Understanding food allergy through neuroimmune interactions in the gastrointestinal tract
Ann Allergy Asthma Immunol. 2023 Jun 16:S1081-1206(23)00419-2. doi: 10.1016/j.anai.2023.06.015. Online ahead of print.ABSTRACTFood allergies are adverse immune reactions to food proteins in the absence of oral tolerance and the incidence of allergies to food including peanut, cow's milk and shellfish has been increasing globally. While advancements have been made towards understanding the contributions of the type 2 immune response to allergic sensitisation, crosstalk between these immune cells and neurons of the enteric nervous system is an area of emerging interest in the pathophysiology of food allergy, given the close ...
Source: Annals of Allergy, Asthma and Immunology - June 18, 2023 Category: Allergy & Immunology Authors: Grace L Burns Simon Keely Source Type: research
Understanding food allergy through neuroimmune interactions in the gastrointestinal tract
Ann Allergy Asthma Immunol. 2023 Jun 16:S1081-1206(23)00419-2. doi: 10.1016/j.anai.2023.06.015. Online ahead of print.ABSTRACTFood allergies are adverse immune reactions to food proteins in the absence of oral tolerance and the incidence of allergies to food including peanut, cow's milk and shellfish has been increasing globally. While advancements have been made towards understanding the contributions of the type 2 immune response to allergic sensitisation, crosstalk between these immune cells and neurons of the enteric nervous system is an area of emerging interest in the pathophysiology of food allergy, given the close ...
Source: Annals of Allergy, Asthma and Immunology - June 18, 2023 Category: Allergy & Immunology Authors: Grace L Burns Simon Keely Source Type: research
Allergenicity of casein containing chalk in milk allergic schoolchildren.
CONCLUSION: Inhalation of chalk dust containing casein can induce asthma symptoms in milk allergic patients. Hidden and nondietary sources of exposure should always be considered in food allergic patients.
PMID: 23622003 [PubMed - in process]
Source: Annals of Allergy, Asthma and Immunology - May 1, 2013 Category: Allergy & Immunology Authors: Larramendi CH, Marco FM, Llombart M, de la Vega A, Chiner E, García-Abujeta JL, Sempere JM Tags: Ann Allergy Asthma Immunol Source Type: research
Oral immunotherapy in cow's milk allergic patients: course and long-term outcome according to asthma status.
CONCLUSION: Patients with asthma are at risk for more severe reactions and are less likely to reach full desensitization during food oral immunotherapy. However, most reach limited daily consumption and most who achieve full desensitization continue to consume milk protein freely after treatment.
PMID: 25595888 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - January 14, 2015 Category: Allergy & Immunology Authors: Elizur A, Goldberg MR, Levy MB, Nachshon L, Katz Y Tags: Ann Allergy Asthma Immunol Source Type: research
An extensively hydrolysed casein-based formula for infants with cows' milk protein allergy: tolerance/hypo-allergenicity and growth catch-up.
Abstract
Children with cows' milk protein allergy (CMPA) are at risk of insufficient length and weight gain, and the nutritional efficacy of hypo-allergenic formulas should be carefully assessed. In 2008, a trial assessed the impact of probiotic supplementation of an extensively hydrolysed casein-based formula (eHCF) on acquisition of tolerance in 119 infants with CMPA. First analysis of the study results showed that the studied formula allowed improvement of food-related symptoms. The scoring of atopic dermatitis (SCORAD) index was assessed at randomisation and after 6 months of feeding. A post hoc analysis was p...
Source: The British Journal of Nutrition - March 17, 2015 Category: Nutrition Authors: Dupont C, Hol J, Nieuwenhuis EE, Cow's Milk Allergy Modified by Elimination and Lactobacilli study group Tags: Br J Nutr Source Type: research
Cow's Milk Desensitization in Anaphylactic Patients: A New Personalized-dose Method.
Abstract
Cow's milk allergy (CMA) is the most frequent food allergy in children and oral immunotherapy (OIT) is a promising approach for treatment of patients. The most challenging cases are anaphylactic with coexisting asthma and proposing safe protocols is crucial especially in high risk groups. Considering that CMA varies among patients, an individualized OIT protocol would be beneficial to achieve a safer and more efficient method of desensitization. 18 children more than 3 years of age with IgE-mediated CMA were enrolled. CMA was confirmed by positive skin prick test (SPT) and positive oral food challenge (OF...
Source: Iranian Journal of Allergy, Asthma and Immunology - February 1, 2017 Category: Allergy & Immunology Authors: Babaie D, Nabavi M, Arshi S, Mesdaghi M, Chavoshzadeh Z, Bemanian MH, Tafakori M, Amirmoini M, Esmailzadeh H, Molatefi R, Rekabi M, Akbarpour N, Masoumi F, Fallahpour M Tags: Iran J Allergy Asthma Immunol Source Type: research
A partially hydrolyzed 100% whey formula and the risk of eczema and any allergy: an updated meta-analysis
ConclusionsThere is evidence to consider use of pHF as an option for reducing the risk of any allergic diseases, particularly eczema. However, the certainty of the evidence is low. One characteristic that makes our meta-analysis distinct from other reviews is that it focuses exclusively on only one type of pHF.
Source: World Allergy Organization Journal - July 26, 2017 Category: Allergy & Immunology Source Type: research
Methods in Allergy/Immunology: Food Challenges
Since there is no in vitro test, which can accurately predict the clinical relevance of a sensitization to food, the oral food challenge still remains the most reliable procedure to confirm or exclude food allergy and to assess the development of tolerance in children with potentially transient food allergies such as to cow ’s milk, hen’s egg, wheat or soy. Although in the last few years component-resolved diagnostic has improved the food allergy diagnostics, especially in peanut and tree nut allergy, the majority of patients still need to undergo oral food challenge.
Source: Journal of Allergy and Clinical Immunology - July 28, 2017 Category: Allergy & Immunology Authors: Barbara K. Ballmer-Weber, Kirsten Beyer Source Type: research
The role of environmental exposure to peanut in the development of clinical allergy to peanut
This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - August 1, 2017 Category: Allergy & Immunology Authors: Ru ‐Xin Foong, Helen Brough Tags: Invited Review Source Type: research
Food challenges
Because there is no in vitro test that can accurately predict the clinical relevance of a sensitization to food, the oral food challenge still remains the most reliable procedure to confirm or exclude food allergy and to assess the development of tolerance in children with potentially transient food allergies, such as t o cow's milk, hen's egg, wheat, or soy. Although in the last few years component-resolved diagnostics have improved food allergy diagnostics, especially in patients with peanut and tree nut allergy, the majority of patients still need to undergo oral food challenge.
Source: Journal of Allergy and Clinical Immunology - July 28, 2017 Category: Allergy & Immunology Authors: Barbara K. Ballmer-Weber, Kirsten Beyer Tags: Methods in allergy and immunology Source Type: research
