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Evaluation of pain-alleviating strategies during allergy shots (subcutaneous immunotherapy): a randomized controlled pilot study
Conclusions. There were no significant differences found between each of the distraction devices and between the control group. Type II error/false negative finding cannot be ruled out because of a small sample. Therefore, we cannot conclude that no true difference exists between each distraction device and the control group simply because of occurrence of a non-significant P-value in our study.PMID:37671862 | DOI:10.23822/EurAnnACI.1764-1489.312
Source: European Annals of Allergy and Clinical Immunology - September 6, 2023 Category: Allergy & Immunology Authors: J Pfieffer K Wehmeier K Gee T DeSanto E Yousef Source Type: research

The Anti-inflammatory Effect of Dexmedetomidine Administration on Patients Undergoing Intestinal Surgery: A Randomized Study
ConclusionDexmedetomidine administration in patients undergoing intestinal surgery inhibited the surgery-induced inflammatory reactions.
Source: Drugs in R&D - November 9, 2021 Category: Drugs & Pharmacology Source Type: research

Sex Differences in IL-33-Induced STAT6-Dependent Type 2 Airway Inflammation
In this study, we have demonstrated that delivery of OVA+IL-33 to the lungs of mice induced an innate inflammatory response that exhibited sex-dependent differences in magnitude and regulation. Compared to males, female mice produced larger amounts of type 2 cytokines and chemokines and had substantially more activated eosinophils and AAM in the lung; each of these responses was significantly lower in female mice lacking STAT6. On the contrary, male mice displayed less inflammation overall, and in some instances, no apparent role for STAT6 was observed. BALF levels of inflammatory mediators and eosinophils were very lo...
Source: Frontiers in Immunology - April 30, 2019 Category: Allergy & Immunology Source Type: research

Blocking IL-19 Signaling Ameliorates Allergen-Induced Airway Inflammation
This study was carried out in accordance with the recommendations of the National Institutes of Health standards and guidelines for the care and use of experimental animals. The protocol was approved by the Animal Ethics Committee of National Cheng Kung University (IACUC NO. 107272 and 105077). Author Contributions J-YW and M-SC designed the study. Y-HW and Y-LL performed the experiments. Y-HW and W-YC analyzed the data. Y-HW, W-YC, and M-SC wrote the manuscript. W-YC and J-YW provided critical technical and scientific guidance and discussion. Funding This work was supported by research grant from the Ministry of Scien...
Source: Frontiers in Immunology - April 29, 2019 Category: Allergy & Immunology Source Type: research

Variation in DNA-Damage Responses to an Inhalational Carcinogen (1,3-Butadiene) in Relation to Strain-Specific Differences in Chromatin Accessibility and Gene Transcription Profiles in C57BL/6J and CAST/EiJ Mice
Conclusions: These results suggest that strain-specific changes in chromatin and transcription in response to chemical exposure lead to a “compensation” for underlying genetic-driven interindividual differences in the baseline chromatin and transcriptional state. This work represents an example of how chemical and environmental exposures can be evaluated to better understand gene-by-environment interactions, and it demonstrates the important role of chromatin response in transcriptomic changes and, potentially, in deleterious effects of exposure. https://doi.org/10.1289/EHP1937 Received: 21 March 2017 Revis...
Source: EHP Research - October 17, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Effects of Orally Ingested Arsenic on Respiratory Epithelial Permeability to Bacteria and Small Molecules in Mice
Conclusions: Peroral arsenic has little effect on local airway immune responses to bacteria but compromises respiratory epithelial barrier integrity, increasing systemic translocation of inhaled pathogens and small molecules. https://doi.org/10.1289/EHP1878 Received: 09 March 2017 Revised: 14 August 2017 Accepted: 16 August 2017 Published: 28 September 2017 Address correspondence to M.B. Fessler, National Institute of Environmental Health Sciences, 111 T.W. Alexander Dr., P.O. Box 12233, Maildrop D2-01, Research Triangle Park, NC 27709 USA. Telephone: (919) 541-3701. Email: fesslerm@niehs.nih.gov *Current address: UN...
Source: EHP Research - September 28, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Maternal Exposure of BALB/c Mice to Indoor NO2 and Allergic Asthma Syndrome in Offspring at Adulthood with Evaluation of DNA Methylation Associated Th2 Polarization
Conclusions: Maternal exposure to indoor environmental NO2 causes allergic asthma-related consequences in offspring absent any subsequent lung provocation and potentiates the symptoms of allergic asthma in adult offspring following postnatal allergic sensitization and challenge; this response is associated with the Th2-based immune response and DNA methylation of the IL4 gene. https://doi.org/10.1289/EHP685 Received: 19 June 2016 Revised: 07 June 2017 Accepted: 19 June 2017 Published: 13 September 2017 Address correspondence to N. Sang, College of Environment and Resource, Shanxi University, Taiyuan, Shanxi 030006, P...
Source: EHP Research - September 13, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research