Filtered By:
Therapy: Cancer Therapy
Nutrition: Calcium
This page shows you your search results in order of date.
Order by Relevance | Date
Total 72 results found since Jan 2013.
A CaCO < sub > 3 < /sub > -based nanoplatform with sonodynamic and tumor microenvironment activated for combined in vitro cancer therapy
CONCLUSION: Accordingly, the potential of QD@Ca/ML-Arg-was demonstrated for in vitro TME modulation, cancer therapeutic efficacy and clinical translation.PMID:37729741 | DOI:10.1016/j.tranon.2023.101771
Source: Translational Oncology - September 20, 2023 Category: Cancer & Oncology Authors: Jiale Cai Guiping Hu Lihua Hu Junge Chen Dan Chen Dan Liu Xiaolei Wang Boxian Hu Cheng Li Source Type: research
Plaque Rupture in a Hodgkin Lymphoma Survivor without Cardiovascular Risk Factors 20 Years after Thoracic Radiotherapy: A Case Report
DISCUSSION: In HL survivors treated with thoracic radiotherapy, a calcium score of zero may not give the same warranty period for cardiac event-free survival compared to the general population. Coronary computed tomography angiography can be a proper diagnostic tool to detect CAD at an early stage after mediastinal irradiation, as performing calcium scoring may not be sufficient in this population to detect non-calcified plaques, which may show rapid progression and lead to acute coronary syndrome. Also, intensive lipid-lowering therapy should be considered in the presence of atherosclerosis in this patient population.PMID...
Source: Atherosclerosis - August 25, 2023 Category: Cardiology Authors: Elissa A S Polomski Michiel A de Graaf J Wouter Jukema M Louisa Antoni Source Type: research
Plasminogen Receptors Promote Lipoprotein(a) Uptake by Enhancing Surface Binding and Facilitating Macropinocytosis
CONCLUSIONS: These findings uncover a novel pathway for Lp(a) endocytosis involving multiple plasminogen receptors that enhance surface binding and stimulate macropinocytosis of Lp(a). Although the findings were produced in cell culture models that have limitations, they could have clinical relevance since drugs that inhibit macropinocytosis are in clinical use, that is, the PI3K inhibitors for cancer therapy and antidepressant compounds, that is, imipramine.PMID:37589135 | DOI:10.1161/ATVBAHA.123.319344
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 17, 2023 Category: Cardiology Authors: Halima Siddiqui Nikita Deo Malcolm T Rutledge Michael J A Williams Gregory M I Redpath Sally P A McCormick Source Type: research
Plasma Membrane Channel TRPM4 Mediates Immunogenic Therapy-Induced Necrosis
Cancer Res. 2023 Jul 31:OF1-OF16. doi: 10.1158/0008-5472.CAN-23-0157. Online ahead of print.ABSTRACTSeveral emerging therapies kill cancer cells primarily by inducing necrosis. As necrosis activates immune cells, potentially, uncovering the molecular drivers of anticancer therapy-induced necrosis could reveal approaches for enhancing immunotherapy efficacy. To identify necrosis-associated genes, we performed a genome-wide CRISPR-Cas9 screen with negative selection against necrosis-inducing preclinical agents BHPI and conducted follow-on experiments with ErSO. The screen identified transient receptor potential melastatin me...
Source: Cell Research - July 31, 2023 Category: Cytology Authors: Santanu Ghosh Rachel Yang Darjan Duraki Junyao Zhu Ji Eun Kim Musarrat Jabeen Chengjian Mao Xinyi Dai Mara R Livezey Matthew W Boudreau Ben H Park Erik R Nelson Paul J Hergenrother David J Shapiro Source Type: research
Characterization of a novel recombinant calcium-binding protein from Arca subcrenata and its anti-hepatoma activities in vitro and in vivo
Int J Biol Macromol. 2023 Jun 21:125513. doi: 10.1016/j.ijbiomac.2023.125513. Online ahead of print.ABSTRACTPrevious studies demonstrated that ASP-3 was a novel calcium-binding protein from Arca subcrenata that effectively inhibited the proliferation of HepG2 cells. To further study the antitumor activity and mechanism of ASP-3, the cytotoxic effects of recombinant ASP-3 were evaluated in HepG2 cells. The results demonstrated that ASP-3 inhibited the proliferation of HepG2 cells by competitively binding to the EGF binding pocket of EGFR and inhibiting the JAK-STAT, RAS-RAF-MEK-ERK, and PI3K-Akt-mTOR signaling pathways medi...
Source: International Journal of Biological Macromolecules - June 23, 2023 Category: Biochemistry Authors: Hui Shi Santosh Panjikar Chunlei Li Xiaozheng Ou Yun Zhou Kunhao Zhang Liyan Song Rongmin Yu Lianli Sun Jianhua Zhu Source Type: research
An insight into the associations between microRNA expression and mitochondrial functions in cancer cell and cancer stem cell
Mol Biol Rep. 2023 Apr 19. doi: 10.1007/s11033-023-08421-5. Online ahead of print.ABSTRACTThe self-renew ability of cancer stem cells (CSCs) continues to challenge our determination for accomplishing cancer therapy breakthrough. Ineffectiveness of current cancer therapies to eradicate CSCs has contributed to chemoresistance and tumor recurrence. Yet, the discoveries of highly effective therapies have not been thoroughly developed. Further insights into cancer metabolomics and gene-regulated mechanisms of mitochondria in CSCs can expedite the development of novel anticancer drugs. In cancer cells, the metabolism is reprogra...
Source: Molecular Biology Reports - April 19, 2023 Category: Molecular Biology Authors: Wee Lin Tan Sethu Thakachy Subha Norhafizah Mohtarrudin Yoke Kqueen Cheah Source Type: research
