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Infectious Disease: Parasitic Diseases

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Total 613 results found since Jan 2013.

Schistosoma mansoni ‐specific immune responses and allergy in Uganda
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Source: Parasite Immunology - November 24, 2017 Category: Parasitology Authors: Gyaviira Nkurunungi, Joyce Kabagenyi, Margaret Nampijja, Richard E Sanya, Bridgious Walusimbi, Jacent Nassuuna, Emily L Webb, Alison M Elliott, Tags: Original Paper Source Type: research

Mast cells, basophils and eosinophils: From allergy to cancer.
Abstract Basophils, eosinophils and mast cells were first recognized by Paul Ehrlich in the late 19th century. These cells have common, but non-redundant roles, in the pathogenesis of allergic diseases and in the protection against parasites. Nevertheless, in virtue of their shared-adeptness to produce a huge variety of immunological mediators and express membrane-bound receptors, they are able to interact with immune and non-immune components of the tissue microenvironment, contributing to the regulation of tissue homeostasis and immune response while participating to further deregulation of tissues transforming ...
Source: Seminars in Immunology - February 7, 2018 Category: Allergy & Immunology Authors: Rigoni A, Colombo MP, Pucillo C Tags: Semin Immunol Source Type: research

Mast cells signal their importance in health and disease
Fc εRI is the primary receptor in mast cells that mediates allergic reactions by inducing rapid release of mediators, an adaptive immune response that might have evolved as a host defense against parasites and venoms. Yet it is apparent that mast cells are also activated through non-IgE receptors, the significance of which is just beginning to be understood. This includes the Mas-related G protein–coupled receptor X2, which might contribute to reactions to diverse antimicrobials and polybasic compounds, and the adhesion G protein–coupled receptor E2, variants of which are associated with fam ilial vibratory urticaria ...
Source: Journal of Allergy and Clinical Immunology - February 15, 2018 Category: Allergy & Immunology Authors: Ana Olivera, Michael A. Beaven, Dean D. Metcalfe Tags: Fundamentals of allergy and immunology Source Type: research

Engineering and stable production of recombinant IgE for cancer immunotherapy and AllergoOncology
AllergoOncology, the emerging discipline of cancer immunology aiming to exploit features of allergy-related immunity to treat tumors,1-3 has catalyzed the development of tumor-specific IgE mAbs as powerful alternatives to commonly used therapeutic IgGs.4-6 IgE, which is associated typically with the pathogenesis of allergic responses and is known for Fc-mediated protective effects in parasitic infection clearance, presents exciting opportunities to unleash previously untapped immune mechanisms and effective antitumor surveillance when focused against cancer antigens.
Source: Journal of Allergy and Clinical Immunology - January 19, 2018 Category: Allergy & Immunology Authors: Silvia Crescioli, Giulia Chiaruttini, Silvia Mele, Kristina M. Ilieva, Giulia Pellizzari, Daniel I.R. Spencer, Richard A. Gardner, Katie E. Lacy, James F. Spicer, Andrew N.J. Tutt, Gerd K. Wagner, Sophia N. Karagiannis Tags: Letter to the Editor Source Type: research

Multifaceted roles of basophils in health and disease
Until recently, basophils had often been neglected in immunologic studies because of their minority status among immune cells or confused with tissue-resident mast cells because of some phenotypic similarities between them in spite of different anatomic localization. It is now appreciated that basophils and mast cells are distinct cell lineages and that basophils play important and nonredundant roles distinct from those played by mast cells. On the one hand, basophils contribute beneficially to protective immunity, particularly against parasitic infections.
Source: Journal of Allergy and Clinical Immunology - December 13, 2017 Category: Allergy & Immunology Authors: Hajime Karasuyama, Kensuke Miyake, Soichiro Yoshikawa, Yoshinori Yamanishi Tags: Fundamentals of allergy and immunology Source Type: research

IJERPH, Vol. 15, Pages 901: Aluminum Adjuvant-Containing Vaccines in the Context of the Hygiene Hypothesis: A Risk Factor for Eosinophilia and Allergy in a Genetically Susceptible Subpopulation?
eth There are similarities between the immune response following immunization with aluminum adjuvants and the immune response elicited by some helminthic parasites, including stimulation of immunoglobulin E (IgE) and eosinophilia. Immunization with aluminum adjuvants, as with helminth infection, induces a Th2 type cell mediated immune response, including eosinophilia, but does not induce an environment conducive to the induction of regulatory mechanisms. Helminths play a role in what is known as the hygiene hypothesis, which proposes that decreased exposure to microbes during a critical time in early life has resulted ...
Source: International Journal of Environmental Research and Public Health - May 3, 2018 Category: Environmental Health Authors: Todd D. Terhune Richard C. Deth Tags: Review Source Type: research

Eosinophilic Pneumonias
Publication date: Available online 4 May 2018 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): James Allen, Michael Wert The eosinophilic pneumonias are a heterogeneous group of diseases characterized by an increase in eosinophils in lung tissue or bronchoalveolar lavage fluid. Many, but not all, of the eosinophilic pneumonias are also associated with a peripheral blood eosinophilia. The etiologies of eosinophilic lung disease are wide ranging and include parasitic infections, medications or other toxins, autoimmune and inflammatory disease, and malignancies. Some eosinophilic pneumonias have ...
Source: The Journal of Allergy and Clinical Immunology: In Practice - May 11, 2018 Category: Allergy & Immunology Source Type: research

The Complicated Dance of Infections and Asthma
The interaction between asthma and infections is a complicated one, and that is the focus of this issue of the Immunology and Allergy Clinics of North America. Infections, both viral and bacterial, have been associated with development and exacerbation of asthma, while parasitic infections may actually help protect against asthma. Furthermore, as our drug armamentarium begins to focus on biologics, which can selectively impair components of the immune response, there is concern that treated patients with asthma will be at risk of developing opportunistic infections.
Source: Immunology and Allergy Clinics of North America - May 20, 2019 Category: Allergy & Immunology Authors: Mitchell H. Grayson Tags: Preface Source Type: research

Pediatric Hypereosinophilia: Characteristics, Clinical Manifestations, and Diagnoses
ConclusionsPediatric hypereosinophilia has an incidence of 54.4 per 100,000 persons per year, with children < 1 year and 6-11 years of age accounting for the majority of affected patients. Pediatric hypereosinophilia is not uncommon and remains under recognized, highlighting a need for clinicians to identify patients that meet criteria for hypereosinophilia and to pursue a thorough evaluation.
Source: The Journal of Allergy and Clinical Immunology: In Practice - May 23, 2019 Category: Allergy & Immunology Source Type: research

Parasitic (Helminthic) Infection While on Asthma Biologic Treatment: Not Everything Is What It Seems
Source: Journal of Asthma and Allergy - December 11, 2019 Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research

Urticaria and the gut
Purpose of review To review recent evidence on the association of urticaria and the gut diseases, focusing on the roles of chronic inflammation with or without Helicobacter pylori (H. Pylori) infection. Recent findings The connection between the gut and urticaria has been discussed for a long time. Some publications have shown that H. pylori can induce chronic spontaneous urticaria (CSU). Recently, it was reported that upper gastrointestinal inflammatory disorders can cause CSU and trigger exacerbations independently of H. pylori. Summary Gastritis and especially H. pylori-induced gastritis has been implicated as p...
Source: Current Opinion in Allergy and Clinical Immunology - June 25, 2020 Category: Allergy & Immunology Tags: SKIN ALLERGY: Edited by Thomas Werfel and Torsten Zuberbier Source Type: research

An Unexpected Infection in Loss-of-Function Mutations in STAT3: Malignant Alveolar Echinococcosis in Liver
Iran J Allergy Asthma Immunol. 2020 Dec 19;19(6):667-675. doi: 10.18502/ijaai.v19i6.4936.ABSTRACTLoss-of-function (LOF) mutations in signal transducer and activator of transcription 3 (STAT3) gene causes autosomal dominant hyper immunoglobulin E syndrome (AD-HIES or Job's Syndrome), a rare and complex primary immunodeficiency (PID) syndrome characterized by increased levels of IgE (>2000 IU/mL), eosinophilia, recurrent staphylococcal skin abscesses, eczema, recurrent pneumonia, skeletal and connective tissue abnormalities. Although bacterial and fungal infections are common in AD-HIES, susceptibility to parasitic infect...
Source: Iranian Journal of Allergy, Asthma and Immunology - January 19, 2021 Category: Allergy & Immunology Authors: Sule Haskologlu Figen Dogu Gulnur Gollu Bahad ır Setenay Akyuzluer Ergin Ciftci Demet Altun Sevgi Keles Meltem Kologlu Aydan Ikinciogullari Source Type: research

Predictive Value of Serum Interleukins in Children with Idiopathic Nephrotic Syndrome
This study was performed to identify alteration of different serum interleukins (ILs) in children with INS, and their predictive value in response to steroid treatment. Three groups of children (27; steroid-sensitive INS, 21; steroid-resistant INS, and 19 healthy controls) with normal serum C3, negative serologic tests of hepatitis B virus (HBV), hepatitis C virus (HCV), human immune deficiency virus (HIV), and parasitic infections were included in this study. Serum concentrations of IL-1β, IL-2, IL-6, IL-8, IL-13, and IL-18 were measured, using quantitative colorimetric sandwich ELISA kits. Children with secondary nephro...
Source: Iranian Journal of Allergy, Asthma and Immunology - January 19, 2021 Category: Allergy & Immunology Authors: Azar Nickavar Ehsan Valavi Baranak Safaeian Parisa Amoori Mostafa Moosavian Source Type: research

An Unexpected Infection in Loss-of-Function Mutations in STAT3: Malignant Alveolar Echinococcosis in Liver
Iran J Allergy Asthma Immunol. 2020 Dec 19;19(6):667-675. doi: 10.18502/ijaai.v19i6.4936.ABSTRACTLoss-of-function (LOF) mutations in signal transducer and activator of transcription 3 (STAT3) gene causes autosomal dominant hyper immunoglobulin E syndrome (AD-HIES or Job's Syndrome), a rare and complex primary immunodeficiency (PID) syndrome characterized by increased levels of IgE (>2000 IU/mL), eosinophilia, recurrent staphylococcal skin abscesses, eczema, recurrent pneumonia, skeletal and connective tissue abnormalities. Although bacterial and fungal infections are common in AD-HIES, susceptibility to parasitic infect...
Source: Iranian Journal of Allergy, Asthma and Immunology - January 19, 2021 Category: Allergy & Immunology Authors: Sule Haskologlu Figen Dogu Gulnur Gollu Bahad ır Setenay Akyuzluer Ergin Ciftci Demet Altun Sevgi Keles Meltem Kologlu Aydan Ikinciogullari Source Type: research