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Infectious Disease: Parasitic Diseases

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Total 613 results found since Jan 2013.

A duodenal mass and acute pancreatitis.
In conclusion, the diagnosis of eosinophilic gastroenteritis should be considered in the patients with a duodenal mass. PMID: 24226730 [PubMed - in process]
Source: The Turkish Journal of Gastroenterology - June 1, 2013 Category: Gastroenterology Authors: Cakır OO, Bıyık M, Güngör G, Ataseven H, Demir A, Tavlı L Tags: Turk J Gastroenterol Source Type: research

NIH-funded scientists identify potential target for malaria drugs
(NIH/National Institute of Allergy and Infectious Diseases) Researchers have identified the protein in malaria-causing Plasmodium parasites that is inhibited by a newly discovered class of anti-malarial compounds known as imidazopyrazines. The protein, phosphatidylinositol 4-kinase, is the first potential malaria drug target shown to be essential to all stages of the Plasmodium life cycle; imidazopyrazines impede its activity throughout this process.
Source: EurekAlert! - Medicine and Health - November 27, 2013 Category: Global & Universal Source Type: news

Parasitic worms and allergies in childhood: Insights from population studies 2008–2013
Abstract The last few decades have seen a marked increase in the global prevalence of allergic diseases particularly among children. Among the factors attributed to this rise has been reduced exposure to pathogens during childhood leading to insufficient maturation of the regulatory arm of developing immune systems. Over the years, a number of epidemiological studies have observed an inverse relationship between parasitic worm (helminth) infections and allergies. The purpose of this review is to highlight insights from population studies conducted among children published between 2008 and 2013 that explore the complex dyna...
Source: Pediatric Allergy and Immunology - November 1, 2013 Category: Allergy & Immunology Authors: Abena S. Amoah, Daniel A. Boakye, Ronald Ree, Maria Yazdanbakhsh Tags: Review Article Source Type: research

Scientists discover genetic marker of drug-resistant malaria
An international team has found a genetic marker for the malaria-causing parasites that are resistant to artemisinin, an important drug for treating the mosquito-borne disease.Among the researchers, who report their findings in a recent online issue of Nature, is a team from the National Institute of Allergy and Infectious Diseases (NIAID), part of the US National Institutes of Health.The World Health Organization (WHO) estimates that 627,000 people died of malaria in 2012.Artemisinin, combined with other drugs, is an important first line of defense against malaria.
Source: Health News from Medical News Today - December 19, 2013 Category: Consumer Health News Tags: Tropical Diseases Source Type: news

Genetic marker of resistance to key malaria drug identified
An international team of researchers has discovered a way to identify, at a molecular level, malaria-causing Plasmodium falciparum parasites that are resistant to artemisinin, the key drug for treating this disease. The research team, which included scientists from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, published their findings in the journal Nature.According to the World Health Organization, an estimated 627,000 people died of malaria in 2012.
Source: Health News from Medical News Today - December 28, 2013 Category: Consumer Health News Tags: Tropical Diseases Source Type: news

Helminth therapy (worms) for induction of remission in inflammatory bowel disease.
CONCLUSIONS: Currently, there is insufficient evidence to allow any firm conclusions regarding the efficacy and safety of helminths used to treat patients with IBD. The evidence for our primary efficacy outcomes in this review comes from one small study and is of low quality due to serious imprecision. We do not have enough evidence to determine whether helminths are safe when used in patients with UC and CD. Further RCTs are required to assess the efficacy and safety of helminth therapy in IBD. PMID: 24442917 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - January 20, 2014 Category: Journals (General) Authors: Garg SK, Croft AM, Bager P Tags: Cochrane Database Syst Rev Source Type: research

Pregnancy and helminth infections
This article is protected by copyright. All rights reserved.
Source: Parasite Immunology - January 28, 2014 Category: Parasitology Authors: Harriet Mpairwe, Robert Tweyongyere, Alison Elliott Tags: Commissioned Review or Article Source Type: research

Targeting Th2-typified immune responses to prevent immunopathology in rheumatic diseases: belittled therapeutic strategies?
Although Th2-associated immune responses have been well defined in atopic diseases and parasitic infections, their potential contribution to immunopathology in rheumatic diseases has scarcely been recognised. This is probably related to the clear predominance of Th1/Th17 over Th2 cells in a number of rheumatic diseases, such as rheumatoid arthritis (RA), psoriatic arthritis and primary Sjögren's syndrome (pSS). Also, whereas a clear role for Th1/Th17 activity in immunopathology has been clearly demonstrated in these diseases, Th2-related phenomena such as IgE production are hardly detected. Indeed, Th2-associated atop...
Source: Annals of the Rheumatic Diseases - February 4, 2014 Category: Rheumatology Authors: Moret, F. M., Radstake, T. R. D. J., van Roon, J. A. G. Tags: Inflammatory bowel disease, Immunology (including allergy), Muscle disease, Inflammation, Ankylosing spondylitis, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Calcium and bone Editorials Source Type: research

Intestinal parasitic infections and atopic dermatitis among Venezuelan Warao Amerindian pre‐ school children
ConclusionGut inflammation caused by G. duodenalis may enhance food allergic reactivity contributing to the manifestation of AD in these children. However, other environmental factors (not considered in this work) as well as an atopic background among the Warao population would also contribute to the presence of AD.
Source: Pediatric Allergy and Immunology - January 13, 2014 Category: Allergy & Immunology Authors: Isabel Hagel, Franca Puccio, Elianska López, Dennis Lugo, Maira Cabrera, María C. Di Prisco Tags: Original Article Source Type: research

Virginia Tech scientists out for blood when it comes to stopping malaria
(Virginia Tech) An assistant professor of biochemistry at Virginia Tech is examining the crucial time when malaria is transmitted from a mosquito parasite to humans. The effort will attempt to identify new drug targets to prevent malaria. The project is supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health.
Source: EurekAlert! - Medicine and Health - March 19, 2014 Category: Global & Universal Source Type: news

News Beyond Our Pages
Vitamin A deficiency is a common nutrient deficiency primarily affecting children in which helminth infections are prevalent. It is known that this micronutrient supports the adaptive immune system through its metabolite, retinoic acid. Spencer et al (Science 2014;343:432-6) examined the possibility that innate lymphoid cells (ILCs), which are known to be involved in barrier maintenance, tissue repair, and host defense, can sustain barrier defense during vitamin A deficiency. The authors discovered that although the deficiency diminishes the adaptive immune system and type 3 ILCs, a dramatic expansion of IL-13–producing ...
Source: Journal of Allergy and Clinical Immunology - March 31, 2014 Category: Allergy & Immunology Authors: Marc E. Rothenberg, Jean Bousquet, Patricia C. Fulkerson Tags: News beyond our pages Source Type: research

Study sheds light on how the immune system protects children from malaria
(NIH/National Institute of Allergy and Infectious Diseases) According to a study published today in PLOS Pathogens, children who live in regions of the world where malaria is common can mount an immune response to infection with malaria parasites that may enable them to avoid repeated bouts of high fever and illness and partially control the growth of malaria parasites in their bloodstream. The findings may help researchers develop future interventions that prevent or mitigate the disease caused by the malaria parasite.
Source: EurekAlert! - Infectious and Emerging Diseases - April 17, 2014 Category: Infectious Diseases Source Type: news

What have studies of non‐industrialised countries told us about the cause of allergic disease?
This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - May 8, 2014 Category: Allergy & Immunology Authors: Andrew Fogarty Tags: Invited Review Source Type: research

Malaria severity not determined solely by parasite levels in blood
(NIH/National Institute of Allergy and Infectious Diseases) Although malaria kills some 600,000 African children each year, most cases of the mosquito-borne parasitic disease in children are mild. Repeated infection does generate some immunity, and episodes of severe malaria are unusual once a child reaches age 5. However, the relative contributions of such factors as the level of malaria-causing parasites in a person's blood -- parasite density -- to disease severity and to development of protective immunity are not well understood.
Source: EurekAlert! - Infectious and Emerging Diseases - May 7, 2014 Category: Infectious Diseases Source Type: news

Parasite Nibbles Human Cells to Death
Source: National Institute of Allergy and Infectious Diseases - Related MedlinePlus Page: Parasitic Diseases
Source: MedlinePlus Health News - April 29, 2014 Category: Consumer Health News Source Type: news