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Infectious Disease: Tuberculosis
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Total 482 results found since Jan 2013.
With $90M contract, Duke aims to accelerate flu/MRSA research
The Duke Clinical Research Institute could receive up to $90 million as one of three national sites chosen to run early clinical trials of new anti-infection therapies.
The institute received a 10-year contract from the National Institute of Allergy and Infectious Diseases to find treatments for diseases like influenza, Methicillin-resistant Staphylococcus aureus (MRSA) and drug-resistant tuberculosis.
The first clinical trials at Duke will likely start later this year, after infrastructure is…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - January 15, 2015 Category: Pharmaceuticals Authors: Jason deBruyn Source Type: news
Delaying initiation of ART for 5 weeks improves survival in patients with HIV infection with cyrptococcal meningitis
Commentary on: Boulware DR, Meya DB, Muzoora C, et al.. Timing of antiretroviral therapy after diagnosis of cryptococcal meningitis. N Engl J Med 2014;370:2487–98. Context Cryptococcal meningitis (CM) is a major cause of mortality for individuals with HIV infection in Africa. Early initiation of antiretroviral therapy (ART) has been shown to decrease mortality in a number of opportunistic infections such as tuberculosis (TB) and Pneumocystis jirovicii pneumonia, but may increase mortality in central nervous system-related opportunistic infections such as TB meningitis.1 The timing of ART however remains controversial...
Source: Evidence-Based Medicine - January 21, 2015 Category: Internal Medicine Authors: Makadzange, A. T., Mothobi, N. Tags: Sexual transmitted infections (viral), Epidemiologic studies, Immunology (including allergy), HIV/AIDS, Meningitis, Pneumonia (infectious disease), Infection (neurology), Ophthalmology, Pneumonia (respiratory medicine) Therapeutics/Prevention Source Type: research
Golimumab 3-year safety update: an analysis of pooled data from the long-term extensions of randomised, double-blind, placebo-controlled trials conducted in patients with rheumatoid arthritis, psoriatic arthritis or ankylosing spondylitis
Conclusions
SC golimumab safety up to 3 years remained consistent with that of other TNF antagonists. Golimumab 100 mg showed numerically higher incidences of serious infections, demyelinating events and lymphoma than 50 mg; safety follow-up up to year 5 continues.
Source: Annals of the Rheumatic Diseases - February 5, 2015 Category: Rheumatology Authors: Kay, J., Fleischmann, R., Keystone, E., Hsia, E. C., Hsu, B., Mack, M., Goldstein, N., Braun, J., Kavanaugh, A. Tags: Open access, Immunology (including allergy), Ankylosing spondylitis, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Epidemiology, Calcium and bone Clinical and epidemiological research Source Type: research
Increased Expression of Forkhead Box Protein 3 Gene of Regulatory T Cells in Patients with Active Tuberculosis
Source: Inflammation and Allergy Drug Targets - February 8, 2015 Category: Allergy & Immunology Authors: Beiranvand, ElhamAbediankenari, SaeidSadegh Rezaei, MohammadKhani, SoghraSardari, SoroushBeiranvand, Behnoush Tags: Articles Source Type: research
Utility of bone marrow examination for workup of fever of unknown origin in patients with HIV/AIDS
Conclusions
This study supports the use of diagnostic BMAB as a rapid decision-making tool in patients with HIV and FUO in the proper clinical setting. BMAB demonstrated infection-related evidence prior to positive bone marrow culture in 75% of cases. Special stains and blood cultures had similar diagnostic yield, but BMAB offers faster results. Thus, this procedure assists in clinical decision making and the refinement of treatment in a more timely manner.
Source: Journal of Clinical Pathology - February 16, 2015 Category: Pathology Authors: Quesada, A. E., Tholpady, A., Wanger, A., Nguyen, A. N. D., Chen, L. Tags: Sexual transmitted infections (viral), Immunology (including allergy), HIV/AIDS, Clinical diagnostic tests Original article Source Type: research
NIH awards 7-year grant to Weill Cornell to tackle global tuberculosis epidemic
(Weill Cornell Medical College) In an effort to stop tuberculosis from becoming progressively less treatable worldwide, the National Institutes of Health has awarded Weill Cornell Medical College more than $6.2 million in first-year funding to support a research collaboration among six institutions in close alliance with voluntary pharmaceutical partners. The total funding, provided by the National Institute of Allergy and Infectious Diseases, could be up to $45.7 million over seven years.
Source: EurekAlert! - Medicine and Health - February 18, 2015 Category: Global & Universal Source Type: news
Management of severe acute malnutrition in low-income and middle-income countries
Kwashiorkor and marasmus, collectively termed severe acute malnutrition (SAM), account for at least 10% of all deaths among children under 5 years of age worldwide, virtually all of them in low-income and middle-income countries. A number of risk factors, including seasonal food insecurity, environmental enteropathy, poor complementary feeding practices, and chronic and acute infections, contribute to the development of SAM. Careful anthropometry is key to making an accurate diagnosis of SAM and can be performed by village health workers or even laypeople in rural areas. The majority of children can be treated at home...
Source: Archives of Disease in Childhood - February 18, 2015 Category: Pediatrics Authors: Trehan, I., Manary, M. J. Tags: Editor's choice, Immunology (including allergy), ADC Global child health, HIV/AIDS, Malnutrition, Child health, Sexual health Source Type: research
Sputum culture conversion as a prognostic marker for end-of-treatment outcome in patients with multidrug-resistant tuberculosis: a secondary analysis of data from two observational cohort studies
Publication date: Available online 26 February 2015 Source:The Lancet Respiratory Medicine Author(s): Ekaterina V Kurbatova , J Peter Cegielski , Christian Lienhardt , Rattanawadee Akksilp , Jaime Bayona , Mercedes C Becerra , Janice Caoili , Carmen Contreras , Tracy Dalton , Manfred Danilovits , Olga V Demikhova , Julia Ershova , Victoria M Gammino , Irina Gelmanova , Charles M Heilig , Ruwen Jou , Boris Kazennyy , Salmaan Keshavjee , Hee Jin Kim , Kai Kliiman , Charlotte Kvasnovsky , Vaira Leimane , Carole D Mitnick , Imelda Quelapio , Vija Riekstina , Sarah E Smith , Thelma Tupasi , Martie van der Walt , Irina A Vasil...
Source: The Lancet Respiratory Medicine - March 5, 2015 Category: Respiratory Medicine Source Type: research
NIH, South African Medical Research Council award $8 million in HIV, TB grants
(NIH/National Institute of Allergy and Infectious Diseases) NIH and the South African Medical Research Council are awarding 31 grants to US and South African scientists to support research targeting HIV/AIDS, tuberculosis and HIV-related co-morbidities and cancers. The awards, which total $8 million in first-year funding, are the first to be issued through the South Africa-US Program for Collaborative Biomedical Research.
Source: EurekAlert! - Infectious and Emerging Diseases - April 13, 2015 Category: Infectious Diseases Source Type: news
Sarilumab for the treatment of ankylosing spondylitis: results of a Phase II, randomised, double-blind, placebo-controlled study (ALIGN)
Conclusions
The ALIGN study shows that IL-6Rα blockade with sarilumab was not an effective treatment for AS. Sarilumab was generally well tolerated with a manageable safety profile.
Source: Annals of the Rheumatic Diseases - May 8, 2015 Category: Rheumatology Authors: Sieper, J., Braun, J., Kay, J., Badalamenti, S., Radin, A. R., Jiao, L., Fiore, S., Momtahen, T., Yancopoulos, G. D., Stahl, N., Inman, R. D. Tags: Open access, Immunology (including allergy), Ankylosing spondylitis, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Calcium and bone Clinical and epidemiological research Source Type: research
Are patients with rheumatoid arthritis still at an increased risk of tuberculosis and what is the role of biological treatments?
Conclusions
In the past decade, the risk of TB has decreased among biological-exposed RA patients but remains higher than in biological-naïve RA patients. Most cases of TB in RA occur in biological-naïve RA patients, underscoring the elevated risk also in these patients.
Source: Annals of the Rheumatic Diseases - May 8, 2015 Category: Rheumatology Authors: Arkema, E. V., Jonsson, J., Baecklund, E., Bruchfeld, J., Feltelius, N., Askling, J., Coster, Forsblad, Geborek, Jacobsson, Klarskog, Kristensen, Lindblad, Rantapaa-Dahlqvist, van Vollenhoven, on behalf of the ARTIS Study Group Tags: Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Epidemiology Clinical and epidemiological research Source Type: research
Indian Woman Being Treated in U.S. for Drug-Resistant Tuberculosis
The woman could be at a federal hospital for a year or more, and health officials have tried to find who was in contact with her in three states and on a plane.
Source: NYT Health - June 9, 2015 Category: Consumer Health News Authors: DENISE GRADY Tags: India Tuberculosis Centers for Disease Control and Prevention National Institute of Allergy and Infectious Diseases Indian-Americans Fauci, Anthony S World Health Organization Source Type: news
Extrapulmonary tuberculosis mimicking Mendelian susceptibility to mycobacterial disease in a patient with signal transducer and activator of transcription 1 () gain-of-function mutation
Signal transducer and activator of transcription 1 (STAT1) mutations cause several rare primary immunodeficiencies.1 Chronic mucocutaneous candidiasis disease (CMCD) is characterized by persistent or recurrent skin, nail, and mucosal membrane infections caused by Candida albicans. Patients with Mendelian susceptibility to mycobacterial disease (MSMD) suffer from atypical mycobacterial infections or severe tuberculosis infections. The gain-of-function STAT1 mutations cause an autosomal-dominant form of CMCD,2 whereas the loss-of-function STAT1 alleles cause MSMD.
Source: Journal of Allergy and Clinical Immunology - August 1, 2015 Category: Allergy & Immunology Authors: Shinsuke Kataoka, Hideki Muramatsu, Yusuke Okuno, Yuta Hayashi, Yoko Mizoguchi, Miyuki Tsumura, Satoshi Okada, Masao Kobayashi, Chiaki Sano, Haruki Sato, Ichiro Oh-iwa, Masahumi Ito, Daiei Kojima, Asahito Hama, Yoshiyuki Takahashi, Seiji Kojima Tags: Letter to the Editor Source Type: research
Why authors use multiple sclerosis in novels, plays and short stories?
MS is a relatively new disease probably first described in 1843 by an English aristocrat Sir Augustus C'Este'. Earlier description of symptoms typical of MS such as Lidwina Von Schiedan of Holland 1880–1933 are considered doubtful.
In order to indentify fictional characters suffering from MS I have first – in 1996-used literary works similar to me; later the internet was searched.
After locating fictional people with MS I have written to the authors themselves or to their publishers inquiring the reason they used MS.
Several of my enquiry letters remained unanswered possibly undelivered-(attempts are now made t...
Source: Journal of Neurology, Neurosurgery and Psychiatry - August 13, 2015 Category: Neurosurgery Authors: Elian, M. Tags: Genetics, Immunology (including allergy), Multiple sclerosis, Musculoskeletal syndromes MEMBERS ' POSTERS Source Type: research
Strong evidence for tuberculosis screening before psoriasis, PsA biologic therapy
Tuberculosis is the only condition in patients with psoriasis or psoriatic arthritis who are being treated with systemic biologic agents for which there is strong evidence in favor of baseline screening, according to a literature review.
Analysis of 26 studies of systemic biologic treatments and...
Source: Skin and Allergy News - August 13, 2015 Category: Dermatology Source Type: news
