Filtered By:
Infectious Disease: Tuberculosis

This page shows you your search results in order of relevance. This is page number 14.

Order by Relevance | Date

Total 482 results found since Jan 2013.

Human Gut-Associated Natural Killer Cells in Health and Disease
Alessandro Poggi1*, Roberto Benelli2, Roberta Venè1, Delfina Costa1, Nicoletta Ferrari1, Francesca Tosetti1 and Maria Raffaella Zocchi3 1Molecular Oncology and Angiogenesis Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy 2Immunology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy 3Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy It is well established that natural killer (NK) cells are involved in both innate and adaptive immunity. Indeed, they can recognize molecules induced at the cell surface by stress signals...
Source: Frontiers in Immunology - May 2, 2019 Category: Allergy & Immunology Source Type: research

A near-fatal Valley Fever case opens doors to new treatment method
Of the 8,000 Californians who will contract Valley Fever this year, most will recover without treatment, and those with more serious cases will require an antifungal medication that clears the infection. But a few will experience a life-threatening form of the disease that ravages the body for reasons unknown.Now, an experimental treatment used by physicians atUCLA Mattel Children ’s Hospital that cured a 4-year-old boy may provide an explanation — and a method for manipulating the immune system to combat not just Valley Fever, but a host of infections.In February 2018, the Gonzalez-Martinez family traveled 200 miles f...
Source: UCLA Newsroom: Health Sciences - July 10, 2019 Category: Universities & Medical Training Source Type: news

Recent advances in addressing tuberculosis give hope for future
(NIH/National Institute of Allergy and Infectious Diseases) In September 2018, the National Institute of Allergy and Infectious Diseases issued its Strategic Plan for Tuberculosis Research, which outlined research priorities to reduce and ultimately end the burden of tuberculosis (TB). Now, a new 'Perspective' in The Journal of Infectious Diseases by NIAID Director Anthony S. Fauci, M.D., and other Institute officials summarizes recent progress in improved TB diagnostics, therapeutic regimens and prevention approaches that made 2019 a 'banner year' for TB research.
Source: EurekAlert! - Infectious and Emerging Diseases - February 11, 2020 Category: Infectious Diseases Source Type: news

Association of tuberculosis infection with asthma in a european multinational cohort
Conclusion: Our study showed that TB infection was associated with asthma, in particular non-allergic asthma. Longitudinal analyses are needed to further explore these results.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Gyawali, S., Lopez Cervantes, J. P., Mustafa, T., Svanes, C., Shigdel, R. Tags: 06.01 - Epidemiology Source Type: research

AI Cough-Monitoring Can Change the Way We Diagnose Disease
How many times do you cough a day? Do you cough more when you’re indoors or outside? Or more often after you eat? Or at night? Chances are, your cough memory might not be that accurate. But all of that information about your coughing patterns could be an untapped resource to better understand your health. Coughs may be benign ways to clear a little extra phlegm, or they could be early signs of more serious conditions such as asthma, GERD (gastroesophageal reflux disease), or even lung cancer. “In the era of precision health, it’s ironic that such a problematic symptom is simply unmeasured,” says Pet...
Source: TIME: Health - April 3, 2023 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized healthscienceclimate Technology Source Type: news

Real-World Safety and Efficacy of Biosimilar CT-P13 in Patients with Immune-Mediated Inflammatory Diseases: Integrated Analysis of Three Japanese Prospective Observational Studies
ConclusionsThe integrated analysis of a large number of patients detected no new safety signals with long-term CT-P13 treatment. Efficacy in rheumatoid arthritis, psoriasis, Crohn ’s disease, and ulcerative colitis cases was confirmed in biologic-naïve patients and switched patients from the originator infliximab or other biologics.
Source: Drug Safety - September 12, 2023 Category: Drugs & Pharmacology Source Type: research

Isoniazid prophylaxis started at 3-4 months of life does not prevent tuberculosis disease or infection in both HIV-infected and uninfected children
Setting: South Africa and Botswana Patients: The study looked at infants who were born to HIV-infected women. To be included in the study, the infants had to be between 91 and 120 days of life, not infected with or exposed to a case of tuberculosis, without other chronic illness, or immunosuppressed from an infection other than HIV. A total of 1351 children were included in the analysis and were split into two groups based on their HIV status after testing: HIV positive and HIV negative (table 1). Intervention: The infants in both groups were randomly assigned to receive either isoniazid at a daily dose of 10–20...
Source: Archives of Disease in Childhood - Education and Practice - January 16, 2013 Category: Pediatrics Authors: Iro, M. A., Brown, N. Tags: Epidemiologic studies, Immunology (including allergy), Drugs: infectious diseases, HIV/AIDS, Child health, Infant health, Sexual health Structured abstracts of sentinel articles: Picket Source Type: research

What Causes Spontaneous Pneumothorax?
Discussion “A pneumothorax is a collection of air in the pleural space, and it can be categorized into spontaneous, traumatic or iatrogenic. Spontaneous pneumothorax can be further classified into primary with no clinical evidence of underlying lung disease or secondary due to pre-existing lung disease.” Spontaneous pneumothorax is a condition that is relatively rare in pediatrics. There is a bimodal age distribution – neonates and late adolescence. It is caused by tearing of the visceral pleural. Clinical signs include chest pain, dyspnea, tachycardia, tracheal deviation towards contralateral side, hypot...
Source: PediatricEducation.org - April 22, 2013 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news

To x-ray or not to x-ray? Screening asymptomatic children for pulmonary TB: a retrospective audit
Conclusions In contrast to the results from studies in adults, a CXR identified a small but noteworthy number of children with findings suggestive of pulmonary TB in the absence of clinical symptoms.
Source: Archives of Disease in Childhood - May 9, 2013 Category: Pediatrics Authors: Gwee, A., Pantazidou, A., Ritz, N., Tebruegge, M., Connell, T. G., Cain, T., Curtis, N. Tags: Immunology (including allergy), Child health, Radiology, Clinical diagnostic tests, Radiology (diagnostics), Screening (epidemiology), Screening (public health) Original article Source Type: research

Question 1 * What are the options for treating latent TB infection in children?
Scenario You are looking after a previously well, HIV-negative 4-year-old boy who has recently migrated to Australia from Sudan. He is BCG-immunised and reports no history of TB contact. His tuberculin skin test (TST) is positive (16 mm induration) and his chest x-ray (CXR) is normal. You diagnose latent tuberculosis infection (LTBI) and wonder what would be the best treatment regimen. Structured clinical question In a child with LTBI [patient], what is the best treatment regimen [intervention] taking into account four criteria: treatment compliance, drug adverse effects, treatment efficacy and cost [outcomes]? Search...
Source: Archives of Disease in Childhood - May 9, 2013 Category: Pediatrics Authors: Gwee, A., Coghlan, B., Curtis, N. Tags: ADC Archimedes, Clinical trials (epidemiology), Immunology (including allergy), Drugs: infectious diseases, HIV/AIDS, Childhood nutrition, Diet, Childhood nutrition (paediatrics), Child health, Infant health, Infant nutrition (including breastfeeding), Ra Source Type: research

Towards evidence based medicine for paediatricians
Getting it straight from the start For  more than a decade Archimedes has presented clinical queries and appraised the evidence that emerges, leading on to a clinical conclusion to the dilemma. What is strikingly common is that many questions can start in a muddle, and a failure to get an ‘evidence-based answer’ might actually be a failure to ask an accurate question. In a recent trans-disciplinary teaching session, one anaesthetist summarised the formulation of evidence-based medicine (EBM) questions as ‘Does drug A compared to drug B make outcome X happen more or less in patient group Z?’&mda...
Source: Archives of Disease in Childhood - May 9, 2013 Category: Pediatrics Authors: Phillips, B. Tags: ADC Archimedes, Oncology, Journalology, Immunology (including allergy), Child health, Clinical diagnostic tests, Competing interests (ethics), Medical humanities Source Type: research

How to use: interferon {gamma} release assays for tuberculosis
This article reviews the current literature on sensitivity and specificity of IGRA in the diagnosis of LTBI, and summarises current NICE recommendations for the use of IGRA in combination with TST. Although not developed for this purpose, in clinical practice IGRA have also been used as a diagnostic test for active TB. The gold standard for diagnosis of active TB disease is microbiological confirmation by culture of MTB. This article discusses the utility of IGRA as an adjunct to diagnosis of active TB disease, but emphasises that IGRA do not have sufficient sensitivity or specificity to exclude or confirm active TB disease.
Source: Archives of Disease in Childhood - Education and Practice - May 13, 2013 Category: Pediatrics Authors: Pollock, L., Basu Roy, R., Kampmann, B. Tags: Immunology (including allergy), Child health, Clinical diagnostic tests Interpretations Source Type: research

What Causes Spontaneous Pneumothorax?
Discussion “A pneumothorax is a collection of air in the pleural space, and it can be categorized into spontaneous, traumatic or iatrogenic. Spontaneous pneumothorax can be further classified into primary with no clinical evidence of underlying lung disease or secondary due to pre-existing lung disease.” Spontaneous pneumothorax is a condition that is relatively rare in pediatrics. There is a bimodal age distribution – neonates and late adolescence. It is caused by tearing of the visceral pleural. Clinical signs include chest pain, dyspnea, tachycardia, tracheal deviation towards contralateral side, hypot...
Source: PediatricEducation.org - May 20, 2013 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news

C57BL/6 mice need MHC class II Aq to develop collagen-induced arthritis dependent on autoreactive T cells
Conclusions The putative (auto)antigen and its arthritogenic determinants in C57BL/6 mice remains undisclosed, questioning the value of the model for addressing T cell-driven pathological pathways in arthritis. To circumvent this impediment, we recommend MHC class II congenic C57BL/6N.Q mice, expressing Aq, with which T cell determinants have been thoroughly characterised.
Source: Annals of the Rheumatic Diseases - May 30, 2013 Category: Rheumatology Authors: Backlund, J., Li, C., Jansson, E., Carlsen, S., Merky, P., Nandakumar, K.-S., Haag, S., Ytterberg, J., Zubarev, R. A., Holmdahl, R. Tags: Genetics, Immunology (including allergy), Degenerative joint disease, Musculoskeletal syndromes Basic and translational research Source Type: research