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Continuous Venovenous Hemodiafiltration for Hyperlactatemia Caused by Telbivudine in a Patient with Chronic Hepatitis B: A Case Report and Update Review
Abstract Though telbivudine has been reported causing myopathy and elevating creatine kinase (CK), there is still few reports on telbivudine and hyperlactatemia in patients with chronic hepatitis B. Here we report the case of hyperlactaemia during telbivudine treatment. A 26‐year‐old Chinese origin man has been received telbivudine antiviral treatment for chronic hepatitis B since 3 July, 2011, and found the CK was 68 U/L before the anti‐viral treatment. After 3 months of therapy, he generally felt nausea and vomited frequently. The CK checked in local clinic was up to 222 U/L (upper limit of normal 170 U/L). However...
Source: Chinese Journal of Digestive Diseases - June 1, 2014 Category: Gastroenterology Authors: Yan‐Hong Wang, Ben‐Quan Wu, Hui Liu Tags: Case Report Source Type: research

Childhood Macrophagic Myofasciitis: A series from the Indian subcontinent
Conclusion: MMF is a rare inflammatory myopathy that should be considered in the differential diagnosis of congenital myopathies in children. This article is protected by copyright. All rights reserved.
Source: Muscle and Nerve - November 10, 2016 Category: Internal Medicine Authors: Aanchal Kakkar, Madhu Rajeshwari, Aasma Nalwa, Vaishali Suri, Chitra Sarkar, Biswaroop Chakrabarty, Sheffali Gulati, Mehar C Sharma Tags: Research Article Source Type: research

Adverse effects of oral antiviral therapy in chronic hepatitis B.
Authors: Kayaaslan B, Guner R Abstract Oral nucleoside/nucleotide analogues (NAs) are currently the backbone of chronic hepatitis B (CHB) infection treatment. They are generally well-tolerated by patients and safe to use. To date, a significant number of patients have been treated with NAs. Safety data has accumulated over the years. The aim of this article is to review and update the adverse effects of oral NAs. NAs can cause class adverse effects (i.e., myopathy, neuropathy, lactic acidosis) and dissimilar adverse effects. All NAs carry a "Black Box" warning because of the potential risk for mitochondrial dysfunc...
Source: World Journal of Hepatology - March 8, 2017 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Dermatomyositis Induced by Hepatitis B Virus-related Hepatocellular Carcinoma: A Case Report and Review of the Literature.
Authors: Chou JW, Lin YL, Cheng KS, Wu PY, Reanne Ju T Abstract Dermatomyositis or polymyositis as a paraneoplastic syndrome of hepatocellular carcinoma (HCC) is an uncommon event. Few cases have been reported in the literature. We herein report the case of a 55-year-old man with chronic hepatitis B and alcoholism who presented with skin rash. Abdominal computed tomography revealed multiple hypervascular liver tumors consistent with HCC. He subsequently developed dysphagia with proximal limb weakness. Laboratory tests and electromyography demonstrated inflammatory myopathy. We therefore diagnosed the patient with H...
Source: Internal Medicine - July 20, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

The Ca(2+) / CaMKK2 Axis Mediates the Telbivudine Induces Upregulation of Creatine Kinase: Implications for mechanism of Antiviral Nucleoside Analogs Side Effect.
Abstract Telbivudine (LdT), a widely prescribed anti-hepatitis B virus (HBV) drug for the treatment of chronic Hepatitis B (CHB), causes adverse reactions ranging from creatine kinase (CK) elevation to myopathy. The purpose of this study was to explore the mechanism(s) of LdT induced CK elevation. The effects of LdT on mitochondrial morphology and proteins (TK2 and β-actin), oxidative stress, intracellular Ca(2+) levels, Ca(2+)-related signaling pathway (CaMKK2/AMPK), and Ca(2+)-related biomarkers such as superoxide dismutase (SOD) and malondialdehyde (MDA) were assessed in human skeletal muscle cells (HSKMCs). T...
Source: Biochemical Pharmacology - October 13, 2017 Category: Drugs & Pharmacology Authors: Jianfei L, Min W, Chunlai M, Bicui C, Jiming Z, Bin W Tags: Biochem Pharmacol Source Type: research

Dermatomyositis as an extrahepatic manifestation of hepatitis B virus-related hepatocellular carcinoma: A case report and literature review
We reported a case of dermatomyositis with hepatitis B virus (HBV) infection. He incidentally found his lower limbs little weakness accompanied with his wrist erythema. He was found HBsAg positive for forty years with slightly positive of α-fetal protein (AFP). Diagnoses: A dermapathology from his hand-wrist lesions demonstrated a scattered inflammatory infiltrate around the capillaries of the dermis. Abdominal enhanced computer tomography (CT) revealed infiltrative HCC affecting the whole liver, accompanied by liver metastasis and liver cirrhosis. Liver tumor needle biopsy pathology showed HCC with moderate differenti...
Source: Medicine - August 1, 2018 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Neurological Involvement in Primary Systemic Vasculitis
Conclusion Neurological involvement is a common complication of PSV (Table 1), and neurologists play an important role in the identification and diagnosis of PSV patients with otherwise unexplained neurological symptoms as their chief complaint. This article summarizes the neurological manifestations of PSV and hopes to improve neuroscientists' understanding of this broad range of diseases. TABLE 1 Table 1. Common CNS and PNS involvements of primary systemic vasculitis. Author Contributions SZ conceived the article and wrote the manuscript. DY and GT reviewed and edited the manuscript. All authors ...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Unexpected SARS-CoV-2 cardiorespiratory arrest in a myopathy patient undergoing immunosuppressive treatment: A case report
We present an unique circumstance whereas a patient with a 5 year history of inflammatory muscle disease, diagnosed by clinical history and muscle biopsy with elevated creatine kinase levels, suffered a hypoxemic cardiopulmonary arrest due to asymptomatic SARS-CoV-2 after receiving advanced immunosuppressive therapy. Diagnoses: The patient presented with an acute exacerbation of inflammatory muscle disease with dysphagia, muscle weakness, and elevated creatine kinase. Interventions: After no improvement with intravenous immunoglobulin the patient received mycophenolate and plasma exchange therapy. Outcomes: Subseq...
Source: Medicine - July 24, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

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